DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and Adamts18

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_006530858.1	Gene:	Adamts18 / 208936	MGIID:	2442600	Length:	1253	Species:	Mus musculus

Alignment Length:	1366	Identity:	369/1366 - (27%)
Similarity:	554/1366 - (40%)	Gaps:	347/1366 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 GLDDLDEEEHSAFVMPTKV-YNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIW 290
            ||:|     ...||:|.:| ...|....|:::..||.|                  ....||.:
Mouse    91 GLND-----DYVFVVPVEVDSGGSYISHDILHHRKRRS------------------AHGASNSL- 131

  Fly   291 DPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYV 355
                .|.::.||:.|||.|:..|..     .:|.|:...|::......|.|..|    |.|.|::
Mouse   132 ----HYRVSAFGQDLHLELKPSAIL-----SSHFRVQVLGKDGASETREPEVPQ----CLYQGFI 183

  Fly   356 EDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDE------------VLHRVFRKSQRNAR 408
            .:|..|.|:||.|.|::|.|:|.....||.|:.:..:.|            ||::  |.:::..|
Mouse   184 RNDSSSSVAVSTCAGLSGLIRTRDNEFLISPLPQLLAQEHNYSSPAGHHPHVLYK--RTAEKRVR 246

  Fly   409 --------------HAVSKFELGLDDFMSKLEQVQEEEQK----SKSRKLNRKKRH--------- 446
                          |:.|        ......|.||.|..    .|.....|:|::
Mouse   247 WYQDYPGSQRTYPGHSPS--------HTPPASQSQEPEYSHRRWQKRHFCGRRKKYAPKPPAEDA 303

  Fly   447 YADVDNQVYT---------------LEVLIAVDNSMKQFHG-EDLQPYILILMSIVSSIFADASI 495
            |...|....|               :|.|:..|..|.:.|| :|:..|||.:|::|||:|.|.:|
Mouse   304 YLRFDEYGGTGRPRRSAGKSQNGLNVETLVVADAKMVEKHGKDDVTTYILTVMNMVSSLFKDGTI 368

  Fly   496 GNSIRILLVRLISLPN------INDQTHSSNEMLKHFCQF----INQSGYERDTAMLITREPICG 550
            |:.|.|::|.||.|..      ||   |.:::.|..|||:    :.::|...|.|:|:|...||
Mouse   369 GSDINIVVVSLILLEEEPEGLLIN---HHADQSLNSFCQWQSALVGKNGKRHDHAILLTGFDIC- 429

  Fly   551 SVPGKICHMLGLAELGTVCSS-SSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQN 614
            |...:.|..||.|.:..:||. .||:|.:||||..|||:|||.||...|.||.:..  |....:.
Mouse   430 SWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGN--PCRKAEG 492

  Fly   615 NNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL--ETSVGAHIPYGTERLPGEIYSL 677
            |     |||..:..:...:|||.|||.::.:||......||  |........| .::|||:||..
Mouse   493 N-----IMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQTGQYKY-PDKLPGQIYDA 551

  Fly   678 DAQCQLSFGNDFGYCP---TDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKC 739
            |.||:..||.....|.   ..:.||.|||:|.    ..:|.:..:|.|:||.||.| .||::|:|
Mouse   552 DMQCKWQFGAKAKLCSLGVMKDICKSLWCHRV----GHRCETKFMPAAEGTACGLS-MWCRQGQC 611

  Fly   740 VSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQ 804
            |.......|.::|.|..|:.::.||.||||||:...|.|:.|.|:.|||||.||.:.|:.||.:.
Mouse   612 VKLGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCSNPKPQYGGKYCPGSSRIYKLCNINP 676

  Fly   805 CPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY-------EKDACKLFCRMDMKVTYFMLKS 862
            ||..|:|.|.|||...|.:        |...|:.::       |:|.|||:|:.:....:|.:..
Mouse   677 CPENSLDFRAQQCAEYNNK--------PFRGWLYRWKPYTKVEEEDRCKLYCKAENFEFFFAMSG 733

  Fly   863 MVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLN 927
            .|.|||.|:....|.|::|||...|||:||.|.|..|.||||:|.|.||....| |.:|.    :
Mouse   734 KVKDGTPCSPHRNDVCIDGICELVGCDHELGSKAVSDACGVCKGDNSTCKFYKG-LYLSQ----H 793

  Fly   928 DGNEPNKTLYY-VTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVT 991
            ..||     || |..||.||.:|.| |......:::.:........|.|.:...:|..|.:||.|
Mouse   794 KANE-----YYPVVTIPAGARSIEI-QELQLSSSYLAVRSLSQKYYLTGGWSIDWPGDFTFAGTT 852

  Fly   992 MQYTGSSSVVEQV------NTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDY-E 1049
            .:|..|.:..|::      |.|        |:.:|::...:|.       :::.|.:.|..:. :
Mouse   853 FEYQRSFNRPERLYAPGPTNET--------LVFEILTQGKNPG-------IAWKYALPKVMNVTQ 902

  Fly  1050 AEVEIYR--WEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRL 1112
            ...:.|.  |. ...|:|...|.|....:.|.....|..:|...||.....|..:.:.||
Mouse   903 PATKRYHHTWR-TVQSDCSVTCGGGYISIKAICLRDQHTQVNSSFCSVRTKPATEPKICN----- 961

  Fly  1113 NLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSE 1177
                                  .::|                       .||        |:..|
Mouse   962 ----------------------AFSC-----------------------PAY--------WLPGE 973

  Fly  1178 WSTCSKSCGTGSQQREAHC-----YLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNA 1237
            ||.|||||..|.|.|:..|     :.....|...|| |.:.|   |.:.:||:.:||
Mouse   974 WSACSKSCAGGQQSRKIRCVQKKPFQKEEAVLHSLC-PVSTP---TQVQVCNSHACP-------- 1026

  Fly  1238 LAVSNWVIGEWGECNEWC---EKTRSVSCSHPYGIG-----CGSRKPKDVRKCCHIK-------- 1286
               ..|....|.:|::.|   .:.|.|.|..|....     |.|....:.::.|.:.
Mouse  1027 ---PEWSPSPWSQCSKTCGRGVRRREVLCKSPAAETLPESLCSSSPRPEAQEGCVLGRCPKNNRL 1088

  Fly  1287 --YTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLR----TT 1345
              ..|.|::||..||.||::::..|.   :..:.|   :.:...|..|  |.:.:|.|.    ..
Mouse  1089 QWIASAWSECSATCGLGVRKRELKCV---EKTLQG---KLITFPERRC--RNIKKPSLELEEACN 1145

  Fly  1346 TKSCRIN----CKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNNC 1406
            .::|.:.    ..|.:|.|::|...|....|||.|             ||..:.|||     ::|
Mouse  1146 QRTCPVYSMAVASWYSSPWQQCTVTCGGGVQTRSV-------------HCMQQGRPS-----SSC 1192

  Fly  1407 VRRQS-RVISQCN---CEGVEKRRD-----------------FCFNSHKGRIACPTRARVERHSC 1450
            :..|. .|:..||   |...||:.|                 .|.:...|:..|        .||
Mouse  1193 LLHQKPPVLRACNTNFCPAPEKKDDPSCVDFFSWCHLVPQHGVCNHKFYGKQCC--------RSC 1249

  Fly  1451 T 1451
            |
Mouse  1250 T 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	32/107 (30%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	77/226 (34%)
		Reprolysin	457..655	CDD:279729	76/209 (36%)
		Salp15	<696..745	CDD:288931	19/48 (40%)
		TSP1	754..806	CDD:214559	24/51 (47%)
		ADAM_spacer1	937..1042	CDD:283607	26/111 (23%)
		TSP1	1172..1229	CDD:214559	21/61 (34%)
		GON	1495..1687	CDD:285848
Adamts18	XP_006530858.1	Pep_M12B_propep	99..237	CDD:366707	42/169 (25%)
		ZnMc_ADAMTS_like	327..528	CDD:239801	76/211 (36%)
		ADAM_CR_2	545..612	CDD:375321	27/71 (38%)
		TSP1	626..678	CDD:214559	24/51 (47%)
		ADAM_spacer1	783..895	CDD:368694	31/137 (23%)
		TSP1	969..1026	CDD:214559	21/60 (35%)
		TSP1	1029..1083	CDD:214559	11/53 (21%)
		TSP1	1093..1150	CDD:214559	15/64 (23%)
		TSP1	1162..1210	CDD:214559	18/65 (28%)
		PLAC	1220..1250	CDD:370061	4/37 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.680