Protein Alignment AdamTS-A and Thsd4

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: NP_001035516.2
• Gene: Thsd4 / 207596
• MGIID: 2672033
• Length: 1018
• Species: Mus musculus
• Alignment Length: 1038
• Identity: 242/1038 - (23%)
• Similarity: 368/1038 - (35%)
• Gaps: 308/1038 - (29%)

  Fly   633 WS-WSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDE 696
            |. ||.|||......:|:| :.||.:|..|.   |..|..|...|:......:.........:.|
Mouse    60 WGPWSACSRSCSGGVMEQT-RPCLPSSYRAR---GGSRPNGRALSITGHVVSAVRTSVPLHRSQE 120

  Fly   697 ECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPW---- 757
            :.:.|..:..|.........|..|.|.|.. .|......||.....|:|||:      .|:
Mouse   121 DQRALAGSNASRQGPAVVRGSRHPQARGRE-PSERRSRTRGPIGPGKYGYGK------APYILPL 178

  Fly   758 ---TPFTPCSLTCGGGVQESRRE---------------------------CNQPV---------- 782
               |..||         |..||:                           .:||:
Mouse   179 QTDTTHTP---------QRLRRQRPSSRHSRSQEASASKQGYRPPTHQFSHSQPLYQSDSGPRSG 234

  Fly   783 --PENGGKY-----------------------------------------------CTGSRKKYR 798
              |.....|                                               |.|:.::|:
Mouse   235 LPPSEASIYQLPLTHDQSYPAASSLFHRPELSSHHGARPHGAAQAFPQHLRSTAISCIGAYRQYK 299

  Fly   799 SCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE---KDACKLFCRMDMKVTYFML 860
            .|||:.||......||.||.:.|    |.|.:....:|.|..|   ...|:|.|:......|...
Mouse   300 LCNTNACPESGRSIREVQCASYN----NKPFMGRFYEWEPFAEVKGNRKCELNCQATGYRFYVRQ 360

  Fly   861 KSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTG---NLLVSN 922
            ...|.|||.|..:....||:|.|:..|||:.|.|...|||||||.|.|..|..|:|   :.|.|
Mouse   361 AEKVIDGTPCDQNGTAICVSGQCKSIGCDDFLGSDKVLDKCGVCGGDNTGCQVVSGVFKHALTS- 424

  Fly   923 LLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVY 987
             ||          .:.|..||:||:.|.||:. :...|::.|.......::||.:....|.|:..
Mouse   425 -LG----------YHRVVEIPQGATKINITEM-HKSNNYLALRSRSGRSIINGNWAIDRPGKYEG 477

  Fly   988 AGVTMQY---------TGSSSVVE--------------QVN--TTYSWKLSRDLIVQIISLDVSP 1027
            .|....|         .|.|.:.|              |.|  ..|.:.:.|:   ..||..|.|
Mouse   478 GGTMFTYKRPNEVSSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMRN---NAISPQVPP 539

  Fly  1028 SKR----------------------------QDT------VLLSYS---YTIDKP---PDYEAEV 1052
            .:|                            :|:      |..|.|   :.:..|   |.:..:.
Mouse   540 HRRPGEPFNGQLEEEDRGQEDREEREKNQEKEDSQVEAPEVFTSESTQTFPVRHPERFPSHRPDN 604

  Fly  1053 EI------------YRWEMQAPSNCDSLC-EGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDR 1104
            .:            :.|:....:.|.:.| :|..:.:..|:......:|...:||.|..|..::.
Mouse   605 LVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRNTHEEVPESYCDSSMKPTPEEE 669

  Fly  1105 ACNT-DCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVD------------MSYC 1156
            .||. .|.....:...||||..|| ||.:.:...|.|.:.|  ||..|.            .|.|
Mouse   670 PCNLFPCPAFWDIGEWSECSKTCG-LGMQHRQVLCRQVYAN--RSLTVQPYRCQHLEKPETTSTC 731

  Fly  1157 KLKFDVAYHEECREGCW-VLSEWSTCSKSCGTGSQQREAHCYLH-NSRVSDDLCNPRTKPHLNTL 1219
            :||.       |.|  | :.::|::||..||.|.:.|:..|..: ...|.|:.||.:.:|:
Mouse   732 QLKI-------CSE--WQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDMVHDEECNMKLRPN---- 783

  Fly  1220 IGICNTESCPTYTKSPNALAVSNWVIGEWGE-CNEWC---EKTRSVSC--SHPYGI---GCGSRK 1275
                :.|:|   ...|.|   .:|.:.||.| |:..|   .:||||.|  :|...:   |||:.:
Mouse   784 ----DIENC---DMGPCA---KSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNR 838

  Fly  1276 PKDVRKC----CHIK---YTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVY--VDESY 1331
            |.:...|    |..|   :|..|:.||::||.|.::::..|.|         :....:  :|...
Mouse   839 PVEATPCDNGPCTGKVEWFTGSWSQCSIECGSGTQQREVICVR---------KNADTFEVLDPYE 894

  Fly  1332 CISRKVHRPKLRTTTKSCRI---NCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDA 1393
            |  ..:.:|   .:.::|.:   ..||.:::|..|...|...::.|:|||.|  .|......||.
Mouse   895 C--SFLEKP---PSQQACHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLS--DDMTPSSLCDP 952

  Fly  1394 KKRPSKRRICN--NCVRRQSRVISQC-----NCEGVEKRRDFCFNSHKGRIACPTRARV-ERH 1448
            :.:|.:|..||  :||   ..|...|     ||..|.:.|...:|.:| ...|.:..|| .||
Mouse   953 QLKPEERESCNTQDCV---PEVDENCKDKYYNCNVVVQARLCVYNYYK-TACCASCTRVANRH 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254
		ZnMc_ADAMTS_like	455..655	CDD:239801	8/22 (36%)
		ADAMTS_CR_2	671..740	CDD:465496	12/68 (18%)
		TSP1	754..806	CDD:214559	17/144 (12%)
		ADAMTS_CR_3	815..911	CDD:437068	35/98 (36%)
		TSP1	1172..1229	CDD:214559	15/58 (26%)
		TSP1_ADAMTS	1243..1282	CDD:465950	16/47 (34%)
		TSP1_ADAMTS	1355..1405	CDD:465950	16/51 (31%)
		GON	1493..1687	CDD:462559
Thsd4	NP_001035516.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..56
		TSP1	57..>81	CDD:214559	8/21 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..240		24/139 (17%)
		ADAMTS_CR_3	317..411	CDD:437068	35/97 (36%)
		ADAMTS_spacer1	413..528	CDD:461796	28/127 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	534..623		11/88 (13%)
		TSP1_ADAMTS	627..676	CDD:465950	11/48 (23%)
		TSP1_ADAMTS	680..736	CDD:465950	18/65 (28%)
		TSP1_ADAMTS	739..793	CDD:465950	16/64 (25%)
		TSP1_ADAMTS	797..850	CDD:465950	17/52 (33%)
		TSP1_ADAMTS	856..912	CDD:465950	13/69 (19%)
		TSP1_ADAMTS	916..967	CDD:465950	16/52 (31%)
		PLAC	975..1005	CDD:462560	8/30 (27%)