DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and adt-1

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_510116.2 Gene:adt-1 / 181412 WormBaseID:WBGene00000082 Length:1461 Species:Caenorhabditis elegans


Alignment Length:1702 Identity:364/1702 - (21%)
Similarity:583/1702 - (34%) Gaps:539/1702 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 LDEEE-HSAFVMPTK--VYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDP 292
            |:||| ...|.:..|  |..|||.||      .|:...|..||...:|:  ..||          
 Worm    26 LNEEELKQVFGVSNKHDVPEYSLIEA------TRHPLKNGNLKMKFTAW--NDTY---------- 72

  Fly   293 HPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQR-HLGCFYSGYVE 356
                         ||.||:::..|..|.::.:|       |...:....|..| :..|.|.|.|:
 Worm    73 -------------HLNLRKNSRIVSPHIISVVR-------HGDDDVTTYAGLRDYEQCHYQGEVK 117

  Fly   357 DDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEVLHRVFRKSQRNARHAVSKFELGL--- 418
            ...:...::|.||.:.|.|......|::|.:.:.     :|.:     :..||.|.|...||   
 Worm   118 SHGNMKAAISDCGALMGSIVMEDHFLVLQTLPKR-----VHHL-----QKERHLVYKRSAGLLTN 172

  Fly   419 --DDFMSKLEQVQEEEQK--SKSRKLNRKKR------HY-------ADVDNQV-------YTLEV 459
              .....::.::|||::.  ..|.:|:....      |:       |.:|:..       .|||:
 Worm   173 AESKIREEITRLQEEQESFCDTSEQLDDPAMTIPAHLHFNYTIPTSAQLDSSFIFPNMDPITLEI 237

  Fly   460 LIAVDNSM-KQFHGEDLQ-------PYILILMSIVSSIFADASIGNSIRILLVR----------L 506
            .:.:|:.: :.|..|.:|       .:.|.|::.|..::...::..::.|::||          |
 Worm   238 GLFLDSKLFEHFEREYIQDAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSAL 302

  Fly   507 ISLPNINDQTHSSNEMLKHFCQF----------INQSGYERDTAMLITREPICGSVPGKICHMLG 561
            .:..:.|.|..|   :|..||::          .:.:.|  |..:|:|...|..:...    :.|
 Worm   303 STGVHKNGQAQS---LLDAFCRYQAHMNPGTDLTDMNHY--DHGVLLTGYDIYHTTTS----VAG 358

  Fly   562 LAELGTVCSS-SSCSIVQDTGLPTAFTMAHELGHILNMNHDD-DDKCMPYVTRQNNNKVLHIMSS 624
            :|.:..:|.. .:||:|:...|..:|.:|||:||.:.|.||. .::|         ||...:||:
 Worm   359 VAPVARMCDPLFACSLVEGLHLGRSFVLAHEMGHNMGMVHDGVQNQC---------NKGCCLMSA 414

  Fly   625 VMGIHMHPWSWSKCSRHFVSEFLEKTDKS----CL-ETSVGA----HIPYGTERLPGEIYSLDAQ 680
            |.|  ....:||.||....:.||.:.|:|    || :.|.|.    |:  ...||||:.::.|.|
 Worm   415 VNG--AGKTTWSDCSVREFNAFLLQLDESGRGNCLRDASPGLISTNHL--SDLRLPGQRFTADQQ 475

  Fly   681 CQLSFGNDFGY-CPT----DEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCV 740
            |...:|.|:.. .|.    |:.|:.|||    |||....:::: |..:|:.||:: .||.:|:|.
 Worm   476 CSYFWGRDYKVEIPNGKAMDDICRILWC----GNSGSTISTAH-PALEGSWCGAN-KWCHKGQCT 534

  Fly   741 SNKHGYGR-QVNGGWGPW------TPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYR 798
            ....|... .::|.|..|      .|...|:::....||...|:|..|.|.||||.|.|:..:..
 Worm   535 HWTFGLTPVPIDGEWSEWGGAEKGCPIQQCAVSGSITVQGQHRDCVNPAPNNGGKTCEGANIRGI 599

  Fly   799 SCNTHQ---------------CPPGSMDPR--EQQCYAMNGRNMNIPGVNPDTKWVPKYEKDACK 846
            .|....               |.....||.  :||   :.|...             ::....|:
 Worm   600 VCGATSSNCLGFTREEFGNKICSSIKYDPHKPDQQ---LTGEGF-------------EHSTQPCR 648

  Fly   847 LFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTC 911
            ::|.: :.......|....|||.|..|::  ||.|.|....|||:. .:.:.:.|...|||  :.
 Worm   649 VWCHL-IGSELIRNKGQFPDGTPCGFDAY--CVGGQCLALSCDNKA-LVEQPEDCPRIEGR--SV 707

  Fly   912 HE-----VTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNE 971
            |:     ......||..||   |.|.                                   |:.:
 Worm   708 HQWEEWSSWSECSVSCGLG---GREV-----------------------------------RERK 734

  Fly   972 LLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWK----------LSRDLIVQIISLDVS 1026
            ..:|:..:         ||:.:......|:........||          |......:....|..
 Worm   735 CSSGRKCQ---------GVSEESRPCEGVLRDCEEFGEWKEWGSCSEKCALGVQKRFRPCLTDQC 790

  Fly  1027 PSKRQDTVLLSYSYTIDKPPDYEAEVEIYRW-EMQAPSNCDSLC-EGRSHRLPACISTTQGVKVA 1089
            .||....         ::|.|.|.     .| .....|:|...| .||.:|:..|:.        
 Worm   791 SSKHLQE---------ERPCDNEG-----CWTNWDEWSSCSQSCGGGRRYRIRKCLD-------- 833

  Fly  1090 PQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTF--TNMQRSNIVD 1152
                ||.....::..:|||...::.:......||.:|| :|.:.:...|....  |..:::...:
 Worm   834 ----DKCDGDDLEKESCNTQKCISQSWGDWLPCSVSCG-IGFQIRERLCDGELCATANKQARTCN 893

  Fly  1153 MSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLN 1217
            ...|...|.::...|     |  .||:|||.:||.|.|.||..| ...|...||           
 Worm   894 QQQCPSAFSLSVWSE-----W--GEWTTCSATCGEGLQSRERSC-RRGSCTEDD----------- 939

  Fly  1218 TLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWC------------------------EKT 1258
                ...|..|   ...|...:...|  .||..| |.|                        |:|
 Worm   940 ----ASQTRRC---VNGPCEHSYLTW--SEWTTC-ETCSSFDSRKRIAKCDGTTENCQDKIDEET 994

  Fly  1259 RSVSC---SHPYGIGCGSRKPK-----DVRKC----------CHIKYTSDWTDCSVQCGEGVKRK 1305
            ..::|   .|.:| ....|:||     |:||.          .|.:..|:|..|||.||.|.:.:
 Worm   995 CDIACLREKHSFG-PISPRRPKLITSNDLRKAFGRPLLPIESIHSEKWSEWGPCSVTCGSGRRVR 1058

  Fly  1306 KQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRIN-CK----WNASDWRRCPA 1365
            .:.|                  .|:.|       |:....|:.|.:| |.    |  |||..|..
 Worm  1059 TRGC------------------QEASC-------PEQHIQTEECNLNSCLELFIW--SDWSSCSK 1096

  Fly  1366 DCSEE-YQTR-------DVRCESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVISQ------ 1416
            .|.:: .|||       :..|.|:    .|.:.|  |..||    |::.  ...|.||:      
 Worm  1097 SCGQDGIQTRQKLCLFNNAECSSY----AESRRC--KDLPS----CSSI--SSGRTISENGFDAP 1149

  Fly  1417 ----------CNCEGVEKRR------------DFCFNSHKGRIAC-------------------- 1439
                      |:|..:...|            .||..:...:|.|                    
 Worm  1150 RWSEWSSWSACSCFSLTSTRRRFCQVVDPTVQGFCAGAILEQIPCAPGSCSPSAGGWSLWSEWSS 1214

  Fly  1440 ------PTRARVERHSCTPP-PHCRRRSAIGSSISSRP-RGTGVSSSRSLNSIGG---------- 1486
                  .|..::....|:.| |..|.....|.|...|| ....|.|...::  ||          
 Worm  1215 CSKDCGDTGHQIRNRMCSEPIPSNRGAYCSGYSFDQRPCVMDNVCSDEKVD--GGWTDWTAWSEC 1277

  Fly  1487 ---SRN--RGTPRSCADLKEMHGYNKDGNYQLEVRSRMVHIYCH-------GMNSRTPQEYVNVD 1539
               .||  |...|.||:.|...|..:......|:........||       ..:..||.      
 Worm  1278 TDYCRNGHRSRTRFCANPKPSQGGAQCTGSDFELNPCFDPARCHLRDGGWSTWSDWTPC------ 1336

  Fly  1540 PQENYSIYYEYRTKQTNSCPPESRGHEYYNDQNSGRTHFRKLRLNITDLRIMDNDFKFADSRGLA 1604
               :.|..:..:|:..:...||.:|    ....||..|    :.::.||...|::   :|....|
 Worm  1337 ---SASCGFGVQTRDRSCSSPEPKG----GQSCSGLAH----QTSLCDLPACDHE---SDGEWSA 1387

  Fly  1605 --QKLGSAGDC----YNRIGQC---PQGD-----FSINMKDTDFSIRPGTVWRMHGQYSVMKRIS 1655
              :..|..|:|    ..|:..|   |..|     |..:.:.|:....|.|.           ..|
 Worm  1388 WNEWSGCMGNCGIGTRTRVRACVSPPVSDGGQPCFGRSSEITECRQSPSTA-----------LCS 1441

  Fly  1656 EFDTTTQMRRGF 1667
            .|.|::.:..|:
 Worm  1442 SFITSSHLADGY 1453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 21/108 (19%)
ZnMc_ADAMTS_like 455..655 CDD:239801 56/233 (24%)
Reprolysin 457..655 CDD:279729 55/231 (24%)
Salp15 <696..745 CDD:288931 15/48 (31%)
TSP1 754..806 CDD:214559 17/72 (24%)
ADAM_spacer1 937..1042 CDD:283607 11/114 (10%)
TSP1 1172..1229 CDD:214559 17/56 (30%)
GON 1495..1687 CDD:285848 37/194 (19%)
adt-1NP_510116.2 Pep_M12B_propep <64..163 CDD:307618 27/140 (19%)
ZnMc_ADAMTS_like 234..448 CDD:239801 57/233 (24%)
TSP1 710..752 CDD:214559 10/88 (11%)
PTZ00441 <762..>806 CDD:240420 9/57 (16%)
TSP1 807..851 CDD:214559 13/55 (24%)
TSP1 855..898 CDD:214559 7/43 (16%)
TSP1 906..952 CDD:214559 20/71 (28%)
TSP1 1041..1082 CDD:214559 15/65 (23%)
TSP_1 <1088..1135 CDD:326556 17/58 (29%)
TSP1 1151..1200 CDD:214559 7/48 (15%)
TSP1 1206..1257 CDD:214559 9/50 (18%)
TSP1 1268..1318 CDD:214559 9/49 (18%)
TSP1 1327..1378 CDD:214559 12/67 (18%)
TSP1 1385..1435 CDD:214559 10/49 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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