Protein Alignment AdamTS-A and adt-3

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: NP_508681.3
• Gene: adt-3 / 180675
• WormBaseID: WBGene00020567
• Length: 940
• Species: Caenorhabditis elegans
• Alignment Length: 1125
• Identity: 231/1125 - (20%)
• Similarity: 383/1125 - (34%)
• Gaps: 372/1125 - (33%)

  Fly   349 CFYSGYVEDDPHSMVSVSLCGG-MTGYIKTSFGAL-LIQPVNRTSSDEVLHRVFRKSQRNARHAV 411
            |.|.|.......:.:.:..||. |.|.:....|.. |||..::|..    |.:.::|..:..|.
 Worm   101 CVYEGESAVRNGTRIGLVGCGNKMNGMVVADNGDYHLIQSHHQTGH----HVIHKRSIESIDHE- 160

  Fly   412 SKFELGLDDFMSKLEQVQEEEQKSKSRK-LNRKKRHYADVDNQVYTLEVLIAVDNSM----KQFH 471
            .:|:...|.:....|::..:....:..| :.|.:.|..|    :.|:|:.:..|::|    |:.:
 Worm   161 CQFDANEDPYPEDREEIAMKSMLIRMVKDIRRAEPHRRD----ILTVELAVFADDAMWDHFKKMY 221

  Fly   472 G----EDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNI----NDQTHSSNE---MLKH 525
            |    |::..:|:.:::.:..::....:...|.|.:||...|.||    |.:.||:.:   :|..
 Worm   222 GKAAEENMHTFIMAVVNNIDVLYTQRLLQPRINIKIVRYEILKNIPHLMNARKHSNGDVDRLLDA 286

  Fly   526 FCQFINQSGYERDT-------AMLITREPICGSVPGKICH------MLGLAELGTVCSS-SSCSI 576
            |||:.|:.....|.       |:|.:         |...|      :.|.|.:..:||. .||:|
 Worm   287 FCQYQNEINPPNDADPRHWDHALLFS---------GYDLHRNGVKTVAGYAPVKGMCSGVRSCTI 342

  Fly   577 VQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMG---IHMHPWSWSKC 638
            .:.....:.|.:.||:||.|.|.||.|::|         :....|||..:|   .|     ||:|
 Worm   343 NEGLDFGSVFVVTHEMGHSLGMYHDGDNEC---------DLRCCIMSPSVGSGKTH-----WSQC 393

  Fly   639 SRHFVSEFL-----EKTDKSCLETSVGAH---IPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTD 695
            |.:.::.|:     :....:||:.:....   :.:.....||::::||.||::..|..:.:...|
 Worm   394 SVNEMATFVGHLGDDFRPPNCLQDASANEQRMVAFKESEPPGQLFTLDEQCEIFHGECWKHELKD 458

  Fly   696 EE-----CKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWG 755
            .:     |:.:||    ||......::: |..:||.|| .|..|::|:||.:.. ..|...|||.
 Worm   459 GQTMQNICQMVWC----GNGEGVIRTAH-PALEGTYCG-FGMICRQGQCVGSSQ-LMRVTVGGWS 516

  Fly   756 PWTPFTPCSLTCGG-----------GVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGS 809
            .|.. .|.. ||||           .:..|.|:||.|...|||..|.|...:...|:...|...|
 Worm   517 TWND-RPAP-TCGGRCSQCEIRGQIRIMRSIRQCNNPSSNNGGAPCQGDEARGMVCHRDVCNGDS 579

  Fly   810 MDP-REQQCYAMNGRNMNIPGVNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVD 873
            ::. ..:.|..:...|. ||......:.: ::|:..||::|.:... |.....|...||..|...
 Worm   580 IENYATRVCSRLRDENA-IPNTILSGEGM-QFEQAMCKIWCLISGS-TNIRTVSNFPDGAPCGPG 641

  Fly   874 SFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYY 938
            .:  |:.|.|||..|.                               |..|..::.:.|...|..
 Worm   642 QY--CIKGECRPLLCG-------------------------------STTLAYSEADCPLSVLQT 673

  Fly   939 VTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQ 1003
            .|                                       |.|:..|::  ..|:.|.::..::
 Worm   674 TT---------------------------------------TPPMPHVHS--VDQFAGKTNPYKE 697

  Fly  1004 ------VNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAP 1062
                  :|....|.:                                            |.....
 Worm   698 HKKTPFLNEWSGWSV--------------------------------------------WSECVT 718

  Fly  1063 SNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISE---CSA 1124
            .:|.                ||||||..:                 .|...:...::.|   |:.
 Worm   719 YDCH----------------TQGVKVRVR-----------------RCLAGVCAGALRERQPCTR 750

  Fly  1125 ACGELGTREKTYACVQTFTNM-------QRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCS 1182
            .|........|....|||.|.       :::|::     ..|.|   |       |  ..||.||
 Worm   751 PCTGSERPLTTSPPQQTFRNRFIAPLPNRQTNMI-----LRKVD---H-------W--GPWSACS 798

  Fly  1183 KSCGTGSQ-QREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIG 1246
            .:||||.: :|..:|      :..:...          .|.|..:||   .::.|.
 Worm   799 VTCGTGQKLRRRENC------IGQECAE----------TGPCVMQSC---RENKNT--------- 835

  Fly  1247 EWGECNEWCEKTRSVSCSHPYGIGCGSRKPKDVRKCCHIKYTSDWTDCSVQCGEGVKRKKQSCTR 1311
             |   .||                                  |.|:||||.|||||:.:|::|..
 Worm   836 -W---TEW----------------------------------SQWSDCSVNCGEGVQFRKRACFA 862

  Fly  1312 VYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINCK--WNA-SDWRRCPADCSEEYQT 1373
            .:        .|....|...|..::..    .|||:...:|..  |.. |.|..|...|....:|
 Worm   863 AF--------CRGKDSDVRNCYGQRCS----ETTTRRPLVNRSGLWTGWSSWSSCSTKCGIGQRT 915

  Fly  1374 RDVRC--ESFQGDGVEDKHC 1391
            |..||  .|..||..|.:.|
 Worm   916 RRRRCYQGSCLGDDNEKERC 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	12/46 (26%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	56/236 (24%)
		ADAMTS_CR_2	671..740	CDD:465496	21/73 (29%)
		TSP1	754..806	CDD:214559	18/62 (29%)
		ADAMTS_CR_3	815..911	CDD:437068	19/95 (20%)
		TSP1	1172..1229	CDD:214559	14/57 (25%)
		TSP1_ADAMTS	1243..1282	CDD:465950	3/38 (8%)
		TSP1_ADAMTS	1355..1405	CDD:465950	14/40 (35%)
		GON	1493..1687	CDD:462559
adt-3	NP_508681.3	ZnMc_ADAMTS_like	201..416	CDD:239801	57/237 (24%)
		ADAMTS_CR_2	434..502	CDD:465496	21/73 (29%)
		TSP1	<699..751	CDD:472794	13/128 (10%)
		TSP1	791..829	CDD:214559	13/55 (24%)
		TSP1	836..881	CDD:214559	19/89 (21%)
		TSP1	896..940	CDD:214559	14/40 (35%)