DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and adt-3

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_508681.3	Gene:	adt-3 / 180675	WormBaseID:	WBGene00020567	Length:	940	Species:	Caenorhabditis elegans

Alignment Length:	1125	Identity:	231/1125 - (20%)
Similarity:	383/1125 - (34%)	Gaps:	372/1125 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 CFYSGYVEDDPHSMVSVSLCGG-MTGYIKTSFGAL-LIQPVNRTSSDEVLHRVFRKSQRNARHAV 411
            |.|.|.......:.:.:..||. |.|.:....|.. |||..::|..    |.:.::|..:..|.
Worm   101 CVYEGESAVRNGTRIGLVGCGNKMNGMVVADNGDYHLIQSHHQTGH----HVIHKRSIESIDHE- 160

  Fly   412 SKFELGLDDFMSKLEQVQEEEQKSKSRK-LNRKKRHYADVDNQVYTLEVLIAVDNSM----KQFH 471
            .:|:...|.:....|::..:....:..| :.|.:.|..|    :.|:|:.:..|::|    |:.:
Worm   161 CQFDANEDPYPEDREEIAMKSMLIRMVKDIRRAEPHRRD----ILTVELAVFADDAMWDHFKKMY 221

  Fly   472 G----EDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNI----NDQTHSSNE---MLKH 525
            |    |::..:|:.:::.:..::....:...|.|.:||...|.||    |.:.||:.:   :|..
Worm   222 GKAAEENMHTFIMAVVNNIDVLYTQRLLQPRINIKIVRYEILKNIPHLMNARKHSNGDVDRLLDA 286

  Fly   526 FCQFINQSGYERDT-------AMLITREPICGSVPGKICH------MLGLAELGTVCSS-SSCSI 576
            |||:.|:.....|.       |:|.:         |...|      :.|.|.:..:||. .||:|
Worm   287 FCQYQNEINPPNDADPRHWDHALLFS---------GYDLHRNGVKTVAGYAPVKGMCSGVRSCTI 342

  Fly   577 VQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMG---IHMHPWSWSKC 638
            .:.....:.|.:.||:||.|.|.||.|::|         :....|||..:|   .|     ||:|
Worm   343 NEGLDFGSVFVVTHEMGHSLGMYHDGDNEC---------DLRCCIMSPSVGSGKTH-----WSQC 393

  Fly   639 SRHFVSEFL-----EKTDKSCLETSVGAH---IPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTD 695
            |.:.::.|:     :....:||:.:....   :.:.....||::::||.||::..|..:.:...|
Worm   394 SVNEMATFVGHLGDDFRPPNCLQDASANEQRMVAFKESEPPGQLFTLDEQCEIFHGECWKHELKD 458

  Fly   696 EE-----CKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWG 755
            .:     |:.:||    ||......::: |..:||.|| .|..|::|:||.:.. ..|...|||.
Worm   459 GQTMQNICQMVWC----GNGEGVIRTAH-PALEGTYCG-FGMICRQGQCVGSSQ-LMRVTVGGWS 516

  Fly   756 PWTPFTPCSLTCGG-----------GVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGS 809
            .|.. .|.. ||||           .:..|.|:||.|...|||..|.|...:...|:...|...|
Worm   517 TWND-RPAP-TCGGRCSQCEIRGQIRIMRSIRQCNNPSSNNGGAPCQGDEARGMVCHRDVCNGDS 579

  Fly   810 MDP-REQQCYAMNGRNMNIPGVNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVD 873
            ::. ..:.|..:...|. ||......:.: ::|:..||::|.:... |.....|...||..|...
Worm   580 IENYATRVCSRLRDENA-IPNTILSGEGM-QFEQAMCKIWCLISGS-TNIRTVSNFPDGAPCGPG 641

  Fly   874 SFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYY 938
            .:  |:.|.|||..|.                               |..|..::.:.|...|..
Worm   642 QY--CIKGECRPLLCG-------------------------------STTLAYSEADCPLSVLQT 673

  Fly   939 VTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQ 1003
            .|                                       |.|:..|::  ..|:.|.::..::
Worm   674 TT---------------------------------------TPPMPHVHS--VDQFAGKTNPYKE 697

  Fly  1004 ------VNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAP 1062
                  :|....|.:                                            |.....
Worm   698 HKKTPFLNEWSGWSV--------------------------------------------WSECVT 718

  Fly  1063 SNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISE---CSA 1124
            .:|.                ||||||..:                 .|...:...::.|   |:.
Worm   719 YDCH----------------TQGVKVRVR-----------------RCLAGVCAGALRERQPCTR 750

  Fly  1125 ACGELGTREKTYACVQTFTNM-------QRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCS 1182
            .|........|....|||.|.       :::|::     ..|.|   |       |  ..||.||
Worm   751 PCTGSERPLTTSPPQQTFRNRFIAPLPNRQTNMI-----LRKVD---H-------W--GPWSACS 798

  Fly  1183 KSCGTGSQ-QREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIG 1246
            .:||||.: :|..:|      :..:...          .|.|..:||   .::.|.
Worm   799 VTCGTGQKLRRRENC------IGQECAE----------TGPCVMQSC---RENKNT--------- 835

  Fly  1247 EWGECNEWCEKTRSVSCSHPYGIGCGSRKPKDVRKCCHIKYTSDWTDCSVQCGEGVKRKKQSCTR 1311
             |   .||                                  |.|:||||.|||||:.:|::|..
Worm   836 -W---TEW----------------------------------SQWSDCSVNCGEGVQFRKRACFA 862

  Fly  1312 VYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINCK--WNA-SDWRRCPADCSEEYQT 1373
            .:        .|....|...|..::..    .|||:...:|..  |.. |.|..|...|....:|
Worm   863 AF--------CRGKDSDVRNCYGQRCS----ETTTRRPLVNRSGLWTGWSSWSSCSTKCGIGQRT 915

  Fly  1374 RDVRC--ESFQGDGVEDKHC 1391
            |..||  .|..||..|.:.|
Worm   916 RRRRCYQGSCLGDDNEKERC 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	12/46 (26%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	56/236 (24%)
		Reprolysin	457..655	CDD:279729	55/234 (24%)
		Salp15	<696..745	CDD:288931	15/53 (28%)
		TSP1	754..806	CDD:214559	18/62 (29%)
		ADAM_spacer1	937..1042	CDD:283607	8/110 (7%)
		TSP1	1172..1229	CDD:214559	14/57 (25%)
		GON	1495..1687	CDD:285848
adt-3	NP_508681.3	ZnMc_ADAMTS_like	201..416	CDD:239801	57/237 (24%)
		ADAM_CR_2	434..502	CDD:375321	21/73 (29%)
		TSP_1	<699..751	CDD:387593	13/128 (10%)
		TSP1	791..829	CDD:214559	13/55 (24%)
		TSP1	836..881	CDD:214559	19/89 (21%)
		TSP1	896..940	CDD:214559	14/40 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810