DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and gon-1

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_001255448.1	Gene:	gon-1 / 177850	WormBaseID:	WBGene00001650	Length:	2165	Species:	Caenorhabditis elegans

Alignment Length:	2118	Identity:	510/2118 - (24%)
Similarity:	750/2118 - (35%)	Gaps:	817/2118 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 GRQLHLVLR-QDASFV------------HNHSMTH---------IRILKEGEEHPGPETEAEAEQ 344
            |...||.|| .||.::            ||.|:.|         :..|...||..|..:..:.:
Worm   105 GHACHLRLRSDDAVYIVHLHRWNQIPDSHNKSVPHFSNSNFAPMVLYLDSEEEVRGGMSRTDPD- 168

  Fly   345 RHLGCFYSGYVED-DPHSMVSVSLC---GGMTGYIKTSFGALLIQPV---NRTSSDEVLHRVFRK 402
                |.|..:|:. ..||:  |:||   .|:.|.:....|...::|:   |.|..|        .
Worm   169 ----CIYRAHVKGVHQHSI--VNLCDSEDGLYGMLALPSGIHTVEPIISGNGTEHD--------G 219

  Fly   403 SQRNARHAVSKFE------------LGLDDFMSKLEQVQEE-----EQKSKSRKLNRKKRHYADV 450
            :.|:.:|.|.||:            ..:::..:.:...|::     |:|::||:......||
Worm   220 ASRHRQHLVRKFDPMHFKSFDHLNSTSVNETETTVATWQDQWEDVIERKARSRRAANSWDHY--- 281

  Fly   451 DNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISL------ 509
                  :|||:..|..|.::||..|:.|:|.|.|.|:||:...|:..||.:::|:||.|
Worm   282 ------VEVLVVADTKMYEYHGRSLEDYVLTLFSTVASIYRHQSLRASINVVVVKLIVLKTENAG 340

  Fly   510 PNINDQTHSSNEMLKHFC---QFIN----QSGYERDTAMLITREPICGSVPGKICHMLGLAELGT 567
            |.|   |.::.:.|:.||   |:.|    .|....|.|:|:||:.||.| .|| |..||||||||
Worm   341 PRI---TQNAQQTLQDFCRWQQYYNDPDDSSVQHHDVAILLTRKDICRS-QGK-CDTLGLAELGT 400

  Fly   568 VCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMH 631
            :|. ..||:|::|.||..|||:||||||:.::.|||:.||..|:....||  .|||:..:..:.|
Worm   401 MCDMQKSCAIIEDNGLSAAFTIAHELGHVFSIPHDDERKCSTYMPVNKNN--FHIMAPTLEYNTH 463

  Fly   632 PWSWSKCSRHFVSEFLE--KTDKSCLETSVGAHIPYGTERL----------PGEIYSLDAQCQLS 684
            |||||.||...:..|||  :....||       .....||.          ||:.|....||:..
Worm   464 PWSWSPCSAGMLERFLENNRGQTQCL-------FDQPVERRYYEDVFVRDEPGKKYDAHQQCKFV 521

  Fly   685 FGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSS-GHWCQRGKCVSNKHGYGR 748
            ||.....||....|:|||| .|...|...|.:.::||||||||..| ..:|..|.||........
Worm   522 FGPASELCPYMPTCRRLWC-ATFYGSQMGCRTQHMPWADGTPCDESRSMFCHHGACVRLAPESLT 585

  Fly   749 QVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPV---------------PENGGKYCTGSRKKYR 798
            :::|.||.|..:..||.|||||||:..|:|:.|.               |.||||||.|.|::||
Worm   586 KIDGQWGDWRSWGECSRTCGGGVQKGLRDCDSPKSENEVETLKSNVTSRPRNGGKYCVGQRERYR 650

  Fly   799 SCNTHQCPPGSMDPREQQCYAMNGRNMNIPGV-NPDTKWVPKY----EKDACKLFCRMDMKVTYF 858
            ||||.:||..:...||.||...|.:::.|.|| :.:|.|||||    ..:.|||:||:.....::
Worm   651 SCNTQECPWDTQPYREVQCSEFNNKDIGIQGVASTNTHWVPKYANVAPNERCKLYCRLSGSAAFY 715

  Fly   859 MLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNL 923
            :|:..|.|||.|..:..|.||.|.|.|||||::|:|..:.||||||.|.:.:|..|.|.......
Worm   716 LLRDKVVDGTPCDRNGDDICVAGACMPAGCDHQLHSTLRRDKCGVCGGDDSSCKVVKGTFNEQGT 780

  Fly   924 LGLNDGNEPNKTLYYVTRIPKGASNIIITQRGY----PDQNFIVLTDDRDNELLNGKF-LKTYPL 983
            .|.|:          |.:||.|::||.|.|:||    .|.|::.|.......||||.| :.....
Worm   781 FGYNE----------VMKIPAGSANIDIRQKGYNNMKEDDNYLSLRAANGEFLLNGHFQVSLARQ 835

  Fly   984 KFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDY 1048
            :..:....::|:||.:::|::|.|  ..:..|:.|.::|:...|..      :||.|.....|:
Worm   836 QIAFQDTVLEYSGSDAIIERINGT--GPIRSDIYVHVLSVGSHPPD------ISYEYMTAAVPN- 891

  Fly  1049 EAEVE-----IYRWEM-QAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACN 1107
             |.:.     :|.|.: ...:.||..|.|:..:...|:..:...:...:.|.....||...|.||
Worm   892 -AVIRPISSALYLWRVTDTWTECDRACRGQQSQKLMCLDMSTHRQSHDRNCQNVLKPKQATRMCN 955

  Fly  1108 TDCRLNLTVTSISECSAACGELGTREKTYACV------QT-------FTNMQRSNI--------- 1150
            .||........:|.|||.||. |.:.:..:||      ||       ..|.:.|:|
Worm   956 IDCSTRWITEDVSSCSAKCGS-GQKRQRVSCVKMEGDRQTPASEHLCDRNSKPSDIASCYIDCSG 1019

  Fly  1151 ----------------------------------VDMSYCKLKFDVAYHEEC-REGC--WVLSEW 1178
                                              ||.|.|..:...|...|| |..|  ||...|
Worm  1020 RKWNYGEWTSCSETCGSNGKMHRKSYCVDDSNRRVDESLCGREQKEATERECNRIPCPRWVYGHW 1084

  Fly  1179 STCSKSCGTGSQQREAHCY------LHNSRVSDDLCNP-RTKPHLNT------LIGI-------- 1222
            |.||:||..|.:.|.|.|.      .|.||     |.| :|:.|.|.      ..|:
Worm  1085 SECSRSCDGGVKMRHAQCLDAADRETHTSR-----CGPAQTQEHCNEHACTWWQFGVWSDCSAKC 1144

  Fly  1223 ----------------------------------CNTESCPTYTKSPNALAVSNWVIGEWGECNE 1253
                                              |:.||||.|.            :|||.:|:.
Worm  1145 GDGVQYRDANCTDRHRSVLPEHRCLKMEKIITKPCHRESCPKYK------------LGEWSQCSV 1197

  Fly  1254 WCE---KTRSVSC---------------------SH--------PY-------------GIG--- 1270
            .||   .:|.|||                     ||        |:             |||
Worm  1198 SCEDGWSSRRVSCVSGNGTEVDMSLCGTASDRPASHQTCNLGTCPFWRNTDWSACSVSCGIGHRE 1262

  Fly  1271 ----------------CGSRKPKDVRKCCHIK-----YTSDWTDCSVQCGEGVKRKKQSCTR--- 1311
                            ||..|..:..:.||:.     ..|.|:.|||.||.|::.:..||||
Worm  1263 RTTECIYREQSVDASFCGDTKMPETSQTCHLLPCTSWKPSHWSPCSVTCGSGIQTRSVSCTRGSE 1327

  Fly  1312 ---------------------------------VYKPDVP------------------GTRKR-- 1323
                                             ..:.|||                  ||::|
Worm  1328 GTIVDEYFCDRNTRPRLKKTCEKDTCDGPRVLQKLQADVPPIRWATGPWTACSATCGNGTQRRLL 1392

  Fly  1324 --RVYV---DESYCISRKVHRPKLRTTTKSCRI-NCK-WNASDWRRCPADC-SEEYQTRDVRCES 1380
              |.:|   .:.||    .|..| ..:|::||: :|. |..::|..|||.| :...|:|:|.|.|
Worm  1393 KCRDHVRDLPDEYC----NHLDK-EVSTRNCRLRDCSYWKMAEWEECPATCGTHVQQSRNVTCVS 1452

  Fly  1381 FQGDG---VEDKHCDAKKRPSKRRICN-----------------------------------NCV 1407
            .:..|   ::|..||.:|||:..|.|.                                   :|.
Worm  1453 AEDGGRTILKDVDCDVQKRPTSARNCRLEPCPKGEEHIGSWIIGDWSKCSASCGGGWRRRSVSCT 1517

  Fly  1408 ------RRQSRVISQCNCE------------------------GVEKRRDFCFNSHKGR----IA 1438
                  .|:.::..:||.|                        ||::|:.:|.:...||    |.
Worm  1518 SSSCDETRKPKMFDKCNEELCPPLTNNSWQISPWTHCSVSCGGGVQRRKIWCEDVLSGRKQDDIE 1582

  Fly  1439 CPTRARVERHSCTPPP-----HCRRRSAIGSSISSRPRGTGVSSSRS------------------ 1480
            |......|:..|..||     |.:..||..:|:||....|..|:|.|
Worm  1583 CSEIKPREQRDCEMPPCRSHYHNKTSSASMTSLSSSNSNTTSSASASSLPILPPVVSWQTSAWSA 1647

  Fly  1481 ----------------------------------------------------------------- 1480

Worm  1648 CSAKCGRGTKRRVVECVNPSLNVTVASTECDQTKKPVEEVRCRTKHCPRWKTTTWSSCSVTCGRG 1712

  Fly  1481 --------------------------LNSIGG--------------------------------- 1486
                                      |||:..
Worm  1713 IRRREVQCYRGRKNLVSDSECNPKTKLNSVANCFPVACPAYRWNVTPWSKCKDECARGQKQTRRV 1777

  Fly  1487 ----------------------------------------------------------------- 1486

Worm  1778 HCISTSGKRAAPRMCELARAPTSIRECDTSNCPYEWVPGDWQTCSKSCGEGVQTREVRCRRKINF 1842

  Fly  1487 ----------------------------------------------------SRNRG-------- 1491
                                                                |:|.|
Worm  1843 NSTIPIIFMLEDEPAVPKEKCELFPKPNESQTCELNPCDSEFKWSFGPWGECSKNCGQGIRRRRV 1907

  Fly  1492 -------------------------------TPRSCADLKEMHGYNKDGNYQLEVRSRMVHIYCH 1525
                                           .|.:|.:||..:...|||||.:.:....:.||||
Worm  1908 KCVANDGRRVERVKCTTKKPRRTQYCFERNCLPSTCQELKSQNVKAKDGNYTILLDGFTIEIYCH 1972

  Fly  1526 GMNSRTPQEYVNVDPQENYSIYYEYRTKQTNSCPPESRGHEYYN-----DQNSGRTHFRKLRLNI 1585
            .|||..|:.|:||:|:.|::..|..:....::||.....::..:     |.::|.|.|.|:|:::
Worm  1973 RMNSTIPKAYLNVNPRTNFAEVYGKKLIYPHTCPFNGDRNDSCHCSEDGDASAGLTRFNKVRIDL 2037

  Fly  1586 TDLRIMDNDFKFADSR-GLAQKLGSAGDCYNRIGQCPQGDFSINMKDTDFSIRPGTVWRMHGQYS 1649
            .:.:....|:.||... |:....|:|||||: :..||||.|||::|.....:.....|...| :.
Worm  2038 LNRKFHLADYTFAKREYGVHVPYGTAGDCYS-MKDCPQGIFSIDLKSAGLKLVDDLNWEDQG-HR 2100

  Fly  1650 VMKRISEFDTTTQMRRGFCGGYCGGCYIAPDSGLYLDV 1687
            ...||..|....:: .|.|||:||.|......||..:|
Worm  2101 TSSRIDRFYNNAKV-IGHCGGFCGKCSPERYKGLIFEV 2137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	29/120 (24%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	88/215 (41%)
		Reprolysin	457..655	CDD:279729	88/213 (41%)
		Salp15	<696..745	CDD:288931	21/49 (43%)
		TSP1	754..806	CDD:214559	30/66 (45%)
		ADAM_spacer1	937..1042	CDD:283607	31/109 (28%)
		TSP1	1172..1229	CDD:214559	25/113 (22%)
		GON	1495..1687	CDD:285848	62/197 (31%)
gon-1	NP_001255448.1	Pep_M12B_propep	93..228	CDD:279848	32/137 (23%)
		Reprolysin	280..493	CDD:279729	92/235 (39%)
		ZnMc_ADAMTS_like	280..490	CDD:239801	92/232 (40%)
		TSP1	591..658	CDD:214559	30/66 (45%)
		ADAM_spacer1	769..885	CDD:283607	34/133 (26%)
		TSP1	1022..1077	CDD:214559	8/54 (15%)
		TSP1	1079..1129	CDD:214559	20/54 (37%)
		TSP1	1131..1185	CDD:214559	4/53 (8%)
		TSP1	1190..1242	CDD:214559	12/51 (24%)
		TSP1	1247..1296	CDD:214559	8/48 (17%)
		TSP1	1296..1354	CDD:214559	12/57 (21%)
		TSP1	1371..1424	CDD:214559	12/57 (21%)
		TSP1	1493..1539	CDD:214559	5/45 (11%)
		TSP1	1546..1599	CDD:214559	11/52 (21%)
		TSP1	1640..1695	CDD:214559	0/54 (0%)
		TSP1	1697..1751	CDD:214559	3/53 (6%)
		TSP1	1813..1881	CDD:214559	0/67 (0%)
		TSP1	1886..1938	CDD:214559	3/51 (6%)
		GON	1942..2137	CDD:285848	62/197 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160160
Domainoid	1	1.000	108	1.000	Domainoid score	I4054
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	536	1.000	Inparanoid score	I647
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48392
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0004456
OrthoInspector	1	1.000	-	-		oto17261
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	LDO	PTHR13723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2551
SonicParanoid	1	1.000	-	-		X3160
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940