DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and madd-4

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_492405.3	Gene:	madd-4 / 172706	WormBaseID:	WBGene00009958	Length:	1045	Species:	Caenorhabditis elegans

Alignment Length:	789	Identity:	187/789 - (23%)
Similarity:	271/789 - (34%)	Gaps:	237/789 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   754 WGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCY 818
            |..|:|::.|:.||||||....|.|..       ..|:|...:::.|....|...|...|:..|
Worm    26 WAAWSPWSSCTKTCGGGVSRQLRRCLT-------SKCSGESVRFKVCAQKTCESKSRLARDTIC- 82

  Fly   819 AMNGRNMNIPGVNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKSMVTDGTSC-AVDSFDKCVNGI 882
              .|..:              ..:..|::.||..:....|:.:  |.|||.| |..|...|..|.
Worm    83 --GGEEI--------------VSRGQCEVVCRSRLTGANFLWR--VDDGTPCQAATSRAVCSKGS 129

  Fly   883 CRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGAS 947
            |:..|||..::|..:.|.||||.||.|||.
Worm   130 CQIVGCDGLISSSFRFDACGVCGGRGDTCD----------------------------------- 159

  Fly   948 NIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSW-- 1010
                                      ||||:..         |:.:||..:|..:.:   ..|
Worm   160 --------------------------NGKFIWK---------VSEEYTACASNCDDI---VDWSG 186

  Fly  1011 ------KLSRDLIVQI--ISLDVSPSKRQDTVLLSYSYTIDK-PPDYEAE-------VEIYRWEM 1059
                  ..|:.::|.:  |:..|.|.|          ...|| .|..||.       ....||..
Worm   187 AGRSIASTSQPIVVCVNAITGRVVPEK----------LCADKLRPKVEARPCPMLICPSRCRWMA 241

  Fly  1060 QAPSNCDSLC-EGRSHRLPACISTTQGVKV-APQ-FCDKSAMPKIDDRACNTDCRLNLTVTSISE 1121
            ...:.|...| ||...|...|:.|...|.| .|. ||:....|..::...:|.|. .......|:
Worm   242 ADWTECVPHCGEGTRKREVYCVQTAHNVTVHVPDTFCENGTRPAAEENCVSTSCG-RWEAGKWSK 305

  Fly  1122 CSAACGELGTREKTYACV------------QTFTNMQ------RSNIVDMSYCKLKFDVAY---- 1164
            |:|:||: |.|.:..|||            |..|...      .:|.:|.:      |.||
Worm   306 CTASCGQ-GVRRRHVACVGGSDCDEGGRPRQETTCYAGIPCSIATNSLDWN------DRAYLDGN 363

  Fly  1165 -------HEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDL------CNPRTKPHL 1216
                   |.:.:....|..||||||.:||||...|...|...|...|..:      |..:.:|
Worm   364 TFGSMDNHNDWQAPRLVAGEWSTCSSTCGTGVMSRTVECVAVNPISSAPIKLPMSECQDQEQP-- 426

  Fly  1217 NTLIGICNTESCPTY--TKSPNALAVSNWVIGEWGECNEWC----EKT----------RSVSCSH 1265
             .|...|...|||..  :|.....|...|..|:|.:|:..|    :|.          :||..|.
Worm   427 -KLFESCEVRSCPLQEDSKLSEDEAPYQWRYGDWTQCSASCLGGKQKAALKCIQVSTGKSVQWSQ 490

  Fly  1266 PYGIGCGSR-------KPKDVRKCCHIKYTSDWTDCSVQCGEGVKRKKQSCTR-VYKPDVPGTRK 1322
                 |.:|       :|.:...|.....||.::|||:.||.|..|:...|.: |.|.|  |...
Worm   491 -----CDARRRPPEKSRPCNQHPCPPFWLTSKYSDCSMSCGSGTARRSVKCAQTVSKTD--GADA 548

  Fly  1323 RRVYVDESYCISRKVHRPKLRTTTKSCRI---NCKWNASDWRRCPADCSEEYQTRDVRCESFQGD 1384
            ..|..|:. |..:|...      |::|.:   ...|..:.|..|...|....:.|.|.||.....
Worm   549 HIVLRDDR-CHFKKPQE------TETCNVVACPATWVTAQWTECSRSCDSGERRRQVWCEIRDSR 606

  Fly  1385 GV----EDKHCDAKKRPSKRRICN--NCVRRQ---SRVISQCNCEGVEKRRDFCFNS----HKG- 1435
            |.    .|..|||..:|....:|:  :|.|.:   :||..| |.|  :|:.......    ::|
Worm   607 GKTQRRPDVECDANTKPQTVEVCSFGSCSRPELLSNRVFEQ-NAE--QKKLTLGIGGVATLYQGT 668

  Fly  1436 --RIACPTR 1442
              :|.||.:
Worm   669 SIKIKCPAK 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559	15/51 (29%)
		ADAM_spacer1	937..1042	CDD:283607	15/114 (13%)
		TSP1	1172..1229	CDD:214559	20/62 (32%)
		GON	1495..1687	CDD:285848
madd-4	NP_492405.3	TSP1	26..71	CDD:214559	15/51 (29%)
		TSP1	382..438	CDD:214559	19/58 (33%)
		IGc2	666..723	CDD:197706	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910