DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and ADAMTS19

DIOPT Version :10

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:XP_047272832.1 Gene:ADAMTS19 / 171019 HGNCID:17111 Length:1228 Species:Homo sapiens


Alignment Length:1337 Identity:335/1337 - (25%)
Similarity:510/1337 - (38%) Gaps:350/1337 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 RSAHKGQEELPQSTHPLANSPPA---TPATLHPRRLDNDTSTDHEPPDGLDDLDEEEHSAFVMPT 243
            |:...|.....:|..|:....|.   :.:.|.|            ||....:.|||..|      
Human    79 RAQAAGSSREVRSVAPVPLEEPVEGRSESRLRP------------PPPSEGEEDEELES------ 125

  Fly   244 KVYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQ------------- 295
                         .|..|.|...:.|...|.|             .|.|.|.             
Human   126 -------------QELPRGSSGAAALSPGAPA-------------SWQPPPPPQPPPSPPPAQHA 164

  Fly   296 --------YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQ----RHLG 348
                    ..:..|.|.|:|:||:|..|:    .....:.:.....|||...|.|.|    ...|
Human   165 EPDGDEVLLRIPAFSRDLYLLLRRDGRFL----APRFAVEQRPNPGPGPTGAASAPQPPAPPDAG 225

  Fly   349 CFYSGYVEDDPHSMVSVSLC-GGMTGYIKTSFGALLIQPVNRTSS-DEVLHRVFRKSQRNARHAV 411
            |||:|.|...|.|:.|.|.| ||:.|:|:.:...:.|:|:|.|.: ....|||:|:.:.......
Human   226 CFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKRSMEEKVT 290

  Fly   412 SKFELGLDDFMSKLEQVQEEEQKSKSRKL---NRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGE 473
            .|..|     .|....:..::.:.:|||:   .|.|| |:....|.|.:|.::..|.:|..:||.
Human   291 EKSAL-----HSHYCGIISDKGRPRSRKIAESGRGKR-YSYKLPQEYNIETVVVADPAMVSYHGA 349

  Fly   474 D-LQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQT---HSSNEMLKHFCQFINQSG 534
            | .:.:||.::::|.::|...|:...:.:.:::||.|.....:.   |...:||:.||::.::..
Human   350 DAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEF 414

  Fly   535 YER------------------DTAMLITREPICGSVPGKICHMLGLAELGTVCSSS-SCSIVQDT 580
            .::                  |.|:||||:..|.. ..:.|..:|:|.|..:||.. .|.|.:|.
Human   415 GKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVH-KDEPCDTVGIAYLSGMCSEKRKCIIAEDN 478

  Fly   581 GLPTAFTMAHELGHILNMNHDDD-DKCMPYVTRQNNNKVLHIMSS--VMGIHMHPWSWSKCSRHF 642
            ||..|||:|||:||.:.:|||:| ..|.         ..|||||.  :.|.::...|||:||:..
Human   479 GLNLAFTIAHEMGHNMGINHDNDHPSCA---------DGLHIMSGEWIKGQNLGDVSWSRCSKED 534

  Fly   643 VSEFLEKTDKSCL-----ETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEE----- 697
            :..||.....:||     ::.....:|   .:|||..|:.|.|||:.||....:|...:.     
Human   535 LERFLRSKASNCLLQTNPQSVNSVMVP---SKLPGMTYTADEQCQILFGPLASFCQEMQVKIQHV 596

  Fly   698 -CKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFT 761
             |..||| :..|  .::|.:...|..|||.| ..|.||:.|:|.| :......:.|.|..|   :
Human   597 ICTGLWC-KVEG--EKECRTKLDPPMDGTDC-DLGKWCKAGECTS-RTSAPEHLAGEWSLW---S 653

  Fly   762 PCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMN 826
            |||.||..|:....|:|  |..::..:.|.|.||:||.|....||.|....|:.||.|.:.|..:
Human   654 PCSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSS 716

  Fly   827 IPGVNPDTKWVPKY---------EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGI 882
                       ||:         |:..|.|||....|....:|...|.|||||.....|.|.||.
Human   717 -----------PKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGR 770

  Fly   883 CRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYY-VTRIPKGA 946
            |:..|||..|.|:|:.|.||||.|...:|..:.|           |.|......|. |..||.||
Human   771 CQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKG-----------DFNHTRGAGYVEVLVIPAGA 824

  Fly   947 SNIIITQRGYPDQNFI----------VLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVV 1001
            ..|.:.:. .|..:::          ....|...:.:|..:...:...|..||.|:.|. ...:.
Human   825 RRIKVVEE-KPAHSYLGNLCYRHREDPTLRDAGKQSINSDWKIEHSGAFNLAGTTVHYV-RRGLW 887

  Fly  1002 EQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCD 1066
            |:::..........|:|.:.        :.....|.|.|||                   ||  |
Human   888 EKISAKGPTTAPLHLLVLLF--------QDQNYGLHYEYTI-------------------PS--D 923

  Fly  1067 SLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGT 1131
            .|.|.:|.:.|           .|.|.                    .|.||..:|.|.||. |.
Human   924 PLPENQSSKAP-----------EPLFM--------------------WTHTSWEDCDATCGG-GE 956

  Fly  1132 REKTYACVQTFTNMQRSNIVDMSYCK-LKFDVAYHEECRE-GC---WVLSEWSTCSKSCGTGSQQ 1191
            |:.|.:|.:..:  :..:|||...|| |........:|.| .|   |:::||:.||::||.|.|.
Human   957 RKTTVSCTKIMS--KNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQS 1019

  Fly  1192 REAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCE 1256
            |:..|       :..|.|       .|||                                    
Human  1020 RQVAC-------TQQLSN-------GTLI------------------------------------ 1034

  Fly  1257 KTRSVSCSHPYGIGCGSRKPKDVRKC----CHIKYTSD-WTDCSVQCGEGVKRKKQSCTRVYKPD 1316
            :.|...|..|        ||...::|    |...:.:. |::|||:||:|::.:...||...|..
Human  1035 RARERDCIGP--------KPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKC 1091

  Fly  1317 VPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINCKWNASDWRRCPADCSEEYQTRDVRCESF 1381
            |..||.|.....|.|               ..|.:   |...||.:|...|.:..|:|.::| ..
Human  1092 VLSTRPREAEDCEDY---------------SKCYV---WRMGDWSKCSITCGKGMQSRVIQC-MH 1137

  Fly  1382 QGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVISQCN 1418
            :..|.....|.:.::|:..|.|:         :..||
Human  1138 KITGRHGNECFSSEKPAAYRPCH---------LQPCN 1165

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep <295..394 CDD:460254 33/125 (26%)
ZnMc_ADAMTS_like 455..655 CDD:239801 64/225 (28%)
ADAMTS_CR_2 671..740 CDD:465496 25/74 (34%)
TSP1 754..806 CDD:214559 18/51 (35%)
ADAMTS_CR_3 815..911 CDD:437068 36/104 (35%)
TSP1 1172..1229 CDD:214559 17/59 (29%)
TSP1_ADAMTS 1243..1282 CDD:465950 5/38 (13%)
TSP1_ADAMTS 1355..1405 CDD:465950 13/49 (27%)
GON 1493..1687 CDD:462559
ADAMTS19XP_047272832.1 Pep_M12B_propep 163..279 CDD:460254 35/119 (29%)
ZnMc_ADAMTS_like 331..548 CDD:239801 65/226 (29%)
ADAMTS_CR_2 565..636 CDD:465496 25/74 (34%)
TSP1 647..696 CDD:214559 19/53 (36%)
ADAMTS_CR_3 <733..799 CDD:437068 29/65 (45%)
ADAMTS_spacer1 801..921 CDD:461796 26/159 (16%)
TSP1_ADAMTS 940..997 CDD:465950 19/59 (32%)
TSP1_ADAMTS 1001..1057 CDD:465950 22/113 (19%)
TSP1_ADAMTS 1061..1103 CDD:465950 14/41 (34%)
TSP1_ADAMTS 1112..1164 CDD:465950 13/61 (21%)
Blue background indicates that the domain is not in the aligned region.

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