DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and ADAMTS18

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_955387.1	Gene:	ADAMTS18 / 170692	HGNCID:	17110	Length:	1221	Species:	Homo sapiens

Alignment Length:	1394	Identity:	376/1394 - (26%)
Similarity:	567/1394 - (40%)	Gaps:	377/1394 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 LDNDTSTDHEPPDGLDDLDEEEHSAFVMPTKVYNY-SLSEADLIYESKRNSDINSFLKESASAFA 277
            |.:|:|:.   ..||:|     ...||.|.:|.:. |....|:::..::        |.||
Human    46 LASDSSSG---ASGLND-----DYVFVTPVEVDSAGSYISHDILHNGRK--------KRSA---- 90

  Fly   278 MTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEA 342
                 :|..:.:     .|..:.||::|||.|:..| .:.:|.:..: :.|:|    ..||:...
Human    91 -----QNARSSL-----HYRFSAFGQELHLELKPSA-ILSSHFIVQV-LGKDG----ASETQKPE 139

  Fly   343 EQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPV-------------------- 387
            .|:   |||.|::.:|..|.|:||.|.|::|.|:|.....||.|:
Human   140 VQQ---CFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHV 201

  Fly   388 --NRTSSDEV-LHRVFRKSQRN--------ARHAVSKFELGLDDFMSKLEQVQEEEQKSKSRKL- 440
              .||:.::: .:|.:..|.||        ..||                 .|..|.:...|:|
Human   202 LYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHA-----------------SQSRETEYHHRRLQ 249

  Fly   441 ------NRKK-----------------------RHYADVDNQVYTLEVLIAVDNSMKQFHGE-DL 475
                  .|||                       |..|....:...:|.|:..|..|.:.||: ::
Human   250 KQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNV 314

  Fly   476 QPYILILMSIVSSIFADASIGNSIRILLVRLISLPN------INDQTHSSNEMLKHFCQF----I 530
            ..|||.:|::||.:|.|.:||:.|.:::|.||.|..      ||   |.:::.|..|||:    |
Human   315 TTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLIN---HHADQSLNSFCQWQSALI 376

  Fly   531 NQSGYERDTAMLITREPICGSVPGKICHMLGLAELGTVCSS-SSCSIVQDTGLPTAFTMAHELGH 594
            .::|...|.|:|:|...|| |...:.|..||.|.:..:||. .||:|.:||||..|||:|||.||
Human   377 GKNGKRHDHAILLTGFDIC-SWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGH 440

  Fly   595 ILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL--ET 657
            ...|.||.:..  |....:.|     |||..:..:...:|||.|||.::.:||......||  |.
Human   441 NFGMIHDGEGN--PCRKAEGN-----IMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEP 498

  Fly   658 SVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP---TDEECKRLWCNRTSGNSNEQCASSNL 719
            .......| .::|||:||..|.||:..||.....|.   ..:.||.|||:|.    ..:|.:..:
Human   499 KQAGQYKY-PDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRV----GHRCETKFM 558

  Fly   720 PWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPE 784
            |.|:||.||.| .||::|:||.......|.::|.|..|:.::.||.||||||:...|.||.|.|:
Human   559 PAAEGTVCGLS-MWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ 622

  Fly   785 NGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY-------EK 842
            .||.:|.||.:.|:.||.:.|...|:|.|.|||...|.:        |...|..::       |:
Human   623 YGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSK--------PFRGWFYQWKPYTKVEEE 679

  Fly   843 DACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGR 907
            |.|||:|:.:....:|.:...|.|||.|:.:..|.|::|:|...|||:||.|.|..|.||||:|.
Human   680 DRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGD 744

  Fly   908 NDTCHEVTGNLLVSNLLGLNDGNEPNKTLYY-VTRIPKGASNIIITQRGYPDQNFIVLTDDRDNE 971
            |.||....|..|          |:.....|| |..||.||.:|.| |......:::.:.......
Human   745 NSTCKFYKGLYL----------NQHKANEYYPVVLIPAGARSIEI-QELQVSSSYLAVRSLSQKY 798

  Fly   972 LLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQV------NTTYSWKLSRDLIVQIISLDVSPSKR 1030
            .|.|.:...:|.:|.:||.|.:|..|.:..|::      |.|        |:.:|:....:|.
Human   799 YLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET--------LVFEILMQGKNPG-- 853

  Fly  1031 QDTVLLSYSYTIDK-----PPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAP 1090
                 :::.|.:.|     ||  ..:...|.|.: ..|.|...|.|....:.|.....|..:|..
Human   854 -----IAWKYALPKVMNGTPP--ATKRPAYTWSI-VQSECSVSCGGGYINVKAICLRDQNTQVNS 910

  Fly  1091 QFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSY 1155
            .||.....|..:.:.||                           .::|
Human   911 SFCSAKTKPVTEPKICN---------------------------AFSC----------------- 931

  Fly  1156 CKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHC-----YLHNSRVSDDLCNPRTKPH 1215
                  .||        |:..|||||||:|..|.|.|:..|     :.....|...|| |.:.|
Human   932 ------PAY--------WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLC-PVSTP- 980

  Fly  1216 LNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWC---EKTRSVSC-------------- 1263
              |.:..||:.:||           ..|.:|.|.:|::.|   .:.|.:.|
Human   981 --TQVQACNSHACP-----------PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCT 1032

  Fly  1264 SHP---YGIGCG-SRKPKDVRKCCHIKY-TSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKR 1323
            |.|   ...||. .|.||:.|    ::: .|.|::||..||.||::::..|:.      .|.:.:
Human  1033 SLPRPELQEGCVLGRCPKNSR----LQWVASSWSECSATCGLGVRKREMKCSE------KGFQGK 1087

  Fly  1324 RVYVDESYCISRKVHRPKLRTTTKSCRINCK----------WNASDWRRCPADCSEEYQTRDVRC 1378
            .:...|..|  |.:.:|.|.......|..|.          |.:..|::|...|....|||.|
Human  1088 LITFPERRC--RNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSV-- 1148

  Fly  1379 ESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQS-RVISQCN---CEGVEKRRD-FC---FN---- 1431
                       ||..:.|||     ::|:..|. .|:..||   |...|||.| .|   ||
Human  1149 -----------HCVQQGRPS-----SSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHL 1197

  Fly  1432 -------SHK--GRIACPTRARVERHSCT 1451
                   :||  |:..|        .|||
Human  1198 VPQHGVCNHKFYGKQCC--------KSCT 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	33/129 (26%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	74/211 (35%)
		Reprolysin	457..655	CDD:279729	74/209 (35%)
		Salp15	<696..745	CDD:288931	19/48 (40%)
		TSP1	754..806	CDD:214559	23/51 (45%)
		ADAM_spacer1	937..1042	CDD:283607	26/111 (23%)
		TSP1	1172..1229	CDD:214559	21/61 (34%)
		GON	1495..1687	CDD:285848
ADAMTS18	NP_955387.1	Pep_M12B_propep	86..202	CDD:279848	35/146 (24%)
		Cysteine switch. /evidence=ECO:0000250	252..259		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..291		4/32 (13%)
		ZnMc_ADAMTS_like	293..494	CDD:239801	74/211 (35%)
		Reprolysin	295..498	CDD:279729	76/213 (36%)
		TSP1	592..643	CDD:214559	23/50 (46%)
		ADAM_spacer1	749..861	CDD:283607	29/137 (21%)
		Spacer	750..876		32/153 (21%)
		TSP1	938..992	CDD:214559	20/57 (35%)
		TSP1	995..1049	CDD:214559	12/53 (23%)
		TSP1	1059..1116	CDD:214559	16/64 (25%)
		TSP1	1131..1178	CDD:214559	17/64 (27%)
		PLAC	1188..1218	CDD:285849	8/37 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.680