DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and ADAMTS16

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_620687.2	Gene:	ADAMTS16 / 170690	HGNCID:	17108	Length:	1224	Species:	Homo sapiens

Alignment Length:	1235	Identity:	341/1235 - (27%)
Similarity:	500/1235 - (40%)	Gaps:	303/1235 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 CFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPV------------NRTSSDEVLHRVFR 401
            |||.|.:....:|.|::|.|.|::|.|:|......::|:            ..:|...||::  |
Human   145 CFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYK--R 207

  Fly   402 KSQRNARHA------------------VSKFELGL---DDFMSKLEQ-----------VQEEEQK 434
            .::.:|..|                  .|...|||   ..|..:.::           :..:|.|
Human   208 STEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYK 272

  Fly   435 S---KSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-EDLQPYILILMSIVSSIFADASI 495
            |   ..|.|.|..|      |:...:|.|:.||..|.|.|| |::..|:|.::::||::|.|.:|
Human   273 SCLRHKRSLLRSHR------NEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTI 331

  Fly   496 GNSIRILLVRLISLPNINDQ-----THSSNEMLKHFCQF----INQSGYERDTAMLITREPICGS 551
            |.:|.|.:|.||.|.  ::|     :|.::..|..|||:    :.:.|...|.|:|:|...|| |
Human   332 GGNINIAIVGLILLE--DEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDIC-S 393

  Fly   552 VPGKICHMLGLAELGTVCSS-SSCSIVQDTGLPTAFTMAHELGHILNMNHD-DDDKCMPYVTRQN 614
            ...:.|..||.|.:..:||. .||:|.:||||..|||:|||.||...|.|| :.:.|    .:..
Human   394 WKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMC----KKSE 454

  Fly   615 NNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIPYG-TERLPGEIYSLD 678
            .|    |||..:......:|||.|||.::.:||......||.........|. .|:||||:|..:
Human   455 GN----IMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDAN 515

  Fly   679 AQCQLSFGNDFGYCPTD---EECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCV 740
            .||:..||.....|..|   :.||.|||:|.    ..:|.:..:|.|:||.||.. .||:.|:||
Human   516 TQCKWQFGEKAKLCMLDFKKDICKALWCHRI----GRKCETKFMPAAEGTICGHD-MWCRGGQCV 575

  Fly   741 SNKHGYG----RQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCN 801
            .    ||    :..:|.|..|:.::|||.||||||....|.|..|.|.:|||:|.||.:..:.||
Human   576 K----YGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCN 636

  Fly   802 THQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY----EKDACKLFCRMDMKVTYFMLKS 862
            :.:||..|:|.|..||...|.|...    ....||.| |    ::|.|||:|..:....:|.|.:
Human   637 SQKCPRDSVDFRAAQCAEHNSRRFR----GRHYKWKP-YTQVEDQDLCKLYCIAEGFDFFFSLSN 696

  Fly   863 MVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTC--HEVTGNLLVSNLLG 925
            .|.|||.|:.||.:.|::|||...||||.|.|.|..|.||||.|.|..|  |.           |
Human   697 KVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHR-----------G 750

  Fly   926 LNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGV 990
            |...:......|::..||.||.:|.|.:... ..::|.:.:......|||.:...:|.::.::|.
Human   751 LYTKHHHTNQYYHMVTIPSGARSIRIYEMNV-STSYISVRNALRRYYLNGHWTVDWPGRYKFSGT 814

  Fly   991 TMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIY 1055
            |..|..|.:  |..|...:...:..|||:::....:|.                          .
Human   815 TFDYRRSYN--EPENLIATGPTNETLIVELLFQGRNPG--------------------------V 851

  Fly  1056 RWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSIS 1120
            .||...|.      .|...:.||..|.|..:                               ..|
Human   852 AWEYSMPR------LGTEKQPPAQPSYTWAI-------------------------------VRS 879

  Fly  1121 ECSAAC--GELGTREKTYACVQTFTNMQRSN-----IVDMSYCKLKFDVAYHEECREGC---WVL 1175
            |||.:|  |::..||..|..::...||...|     :..:..||:           ..|   |.:
Human   880 ECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKV-----------SACPPSWSV 933

  Fly  1176 SEWSTCSKSCGTGSQQREAHC----YLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPN 1236
            ..||.||::||.|:|.|...|    :..:..|...|| |:..|....   .||::|||
Human   934 GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC-PQPAPSSRQ---ACNSQSCP------- 987

  Fly  1237 ALAVSNWVIGEWGECNEWCEK---TRSVSCSH----------PYGIGCGSRKPKDVRKC----CH 1284
                ..|..|.|.||:..|.|   .|:|:|..          |..:.....||:....|    ||
Human   988 ----PAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCH 1048

  Fly  1285 ----IKY-TSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRK---VHRPK 1341
                ::: .|.|:.|||.|..|.:::...|...|   |.|..:.        ..|:|   :.:|.
Human  1049 KPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKY---VSGKYRE--------LASKKCSHLPKPS 1102

  Fly  1342 LRTTTKSCRINC--------------KWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCD 1392
            |........:.|              .|.||.|.:|.|.|....|||.|:|   ...|.....|.
Human  1103 LELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC---LAGGRPASGCL 1164

  Fly  1393 AKKRPSKRRICNNCVRRQSRVISQCNCEGVEKRRDFCFN--------------SHK--GRIACPT 1441
            ..::||....||...           |...||:..||.:              |||  |:..|.|
Human  1165 LHQKPSASLACNTHF-----------CPIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKT 1218

Fly 1442 1441
Human 1219 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	14/56 (25%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	74/211 (35%)
		Reprolysin	457..655	CDD:279729	74/209 (35%)
		Salp15	<696..745	CDD:288931	18/48 (38%)
		TSP1	754..806	CDD:214559	23/51 (45%)
		ADAM_spacer1	937..1042	CDD:283607	22/104 (21%)
		TSP1	1172..1229	CDD:214559	20/63 (32%)
		GON	1495..1687	CDD:285848
ADAMTS16	NP_620687.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..53
		Pep_M12B_propep	83..204	CDD:279848	14/58 (24%)
		Cysteine switch. /evidence=ECO:0000250	247..254		1/6 (17%)
		ZnMc_ADAMTS_like	290..491	CDD:239801	74/211 (35%)
		Reprolysin	292..495	CDD:279729	76/213 (36%)
		TSP1	589..641	CDD:214559	23/51 (45%)
		ADAM_spacer1	746..858	CDD:283607	27/151 (18%)
		Spacer	747..873		32/171 (19%)
		TSP1	931..987	CDD:214559	19/59 (32%)
		TSP1	990..1048	CDD:214559	14/57 (25%)
		TSP1	1058..1115	CDD:214559	15/67 (22%)
		TSP1	1128..1181	CDD:214559	18/66 (27%)
		PLAC	1190..1220	CDD:285849	7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.680