DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and ADAMTS15

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_620686.1 Gene:ADAMTS15 / 170689 HGNCID:16305 Length:950 Species:Homo sapiens


Alignment Length:1010 Identity:325/1010 - (32%)
Similarity:473/1010 - (46%) Gaps:216/1010 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   296 YNLNVFGRQLHLVLRQDASFV-HNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDP 359
            :.:..|....:|.|..||.|: ...|..|:.:..:|      .|...::.|.  |||||.|..:|
Human    55 FQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQG------LTGGSSDLRR--CFYSGDVNAEP 111

  Fly   360 HSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEVLHRVFRKSQRNAR--HAVSKFEL------ 416
            .|..:||||||:.|.........:|.|:...|:.        .:|||::  |.:.:..:      
Human   112 DSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAP--------AAQRNSQGAHLLQRRGVPGGPSG 168

  Fly   417 ------------------GLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAV 463
                              .||.:..:.....|    |:||:.:.:.:.:..:...|   |.|:..
Human   169 DPTSRCGVASGWNPAILRALDPYKPRRAGFGE----SRSRRRSGRAKRFVSIPRYV---ETLVVA 226

  Fly   464 DNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISL------PNINDQTHSSNEM 522
            |.||.:|||.||:.|:|.|::..:.::...||.|.|.|::|:::.|      |.:   |.::...
Human   227 DESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKV---TGNAALT 288

  Fly   523 LKHFCQF---INQSGYER----DTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQD 579
            |::||.:   :|:...:.    |||:|.||:.:||:.   .|..||:|::||:|. ..|||:::|
Human   289 LRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGAT---TCDTLGMADVGTMCDPKRSCSVIED 350

  Fly   580 TGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHM---HPWSWSKCSRH 641
            .|||:|||.||||||:.||.||:...|.....:...|   |:||..: |.:   :|  ||.||..
Human   351 DGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRAN---HMMSPTL-IQIDRANP--WSACSAA 409

  Fly   642 FVSEFLEKTDKSCL--ETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEECKRLWCN 704
            .:::||:.....||  :.|....:|   |.|||..|:|..||:|:||.....||..:.|.:||| 
Human   410 IITDFLDSGHGDCLLDQPSKPISLP---EDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWC- 470

  Fly   705 RTSGNSNEQ--CASSNLPWADGTPCGSSGHWCQRGKCVS----NKHGYGRQVNGGWGPWTPFTPC 763
              :|.:..|  |.:.:.||||||.|| .|..|.:|.||.    |||    :|:|.|..|.|:.||
Human   471 --TGKAKGQMVCQTRHFPWADGTSCG-EGKLCLKGACVERHNLNKH----RVDGSWAKWDPYGPC 528

  Fly   764 SLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDP--REQQCYAMNGRNMN 826
            |.|||||||.:||:|..|.|.||||||.|.|.||||||...||..:...  ||:||.|.||.|.:
Human   529 SRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHS 593

  Fly   827 IPGVNPDTKWVPKYE----KDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAG 887
            ...:.....|||||.    :|.|||.||.:....:::|...|.|||.|:.||...||.|.|..||
Human   594 TNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAG 658

  Fly   888 CDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIIT 952
            ||..|.|..:.||||||.|.|.:|.:||| |....:.|.|          :|..||.|||:|.|.
Human   659 CDGNLGSKKRFDKCGVCGGDNKSCKKVTG-LFTKPMHGYN----------FVVAIPAGASSIDIR 712

  Fly   953 QRGYP----DQNFIVLTDDRDNELLNGKF-LKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKL 1012
            ||||.    |.|::.|.:.:...||||.| :.......|..|..::|:|:.:.||.:..  |..:
Human   713 QRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQA--SRPI 775

  Fly  1013 SRDLIVQIISL-DVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRL 1076
            ...|.|:::|: .::|.:      :.||:.:.|.|..                            
Human   776 LEPLTVEVLSVGKMTPPR------VRYSFYLPKEPRE---------------------------- 806

  Fly  1077 PACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISE-------------------- 1121
                             |||:.|| |.|..:.   |:.:|.|:|.                    
Human   807 -----------------DKSSHPK-DPRGPSV---LHNSVLSLSNQVEQPDDRPPARWVAGSWGP 850

  Fly  1122 CSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYH----EECREGC--WVLSEWST 1180
            |||:||. |.:::...|  ..:..||:    :..|    |.|:.    :.|.|.|  |.||.||.
Human   851 CSASCGS-GLQKRAVDC--RGSAGQRT----VPAC----DAAHRPVETQACGEPCPTWELSAWSP 904

  Fly  1181 CSKSCGTGSQQREAHCYLHNSR-VSDDLCNPRTKP 1214
            ||||||.|.|:|...|..|..| ::.|.||...||
Human   905 CSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKP 939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 29/98 (30%)
ZnMc_ADAMTS_like 455..655 CDD:239801 74/216 (34%)
Reprolysin 457..655 CDD:279729 74/214 (35%)
Salp15 <696..745 CDD:288931 22/54 (41%)
TSP1 754..806 CDD:214559 32/51 (63%)
ADAM_spacer1 937..1042 CDD:283607 33/110 (30%)
TSP1 1172..1229 CDD:214559 23/46 (50%)
GON 1495..1687 CDD:285848
ADAMTS15NP_620686.1 Pep_M12B_propep 24..142 CDD:307618 28/94 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..172 1/20 (5%)
Cysteine switch. /evidence=ECO:0000250 172..179 0/6 (0%)
ZnMc_ADAMTS_like 218..424 CDD:239801 76/220 (35%)
ADAM_CR 437..506 CDD:326582 31/72 (43%)
TSP1 519..571 CDD:214559 32/51 (63%)
ADAM_spacer1 683..801 CDD:310520 39/136 (29%)
Spacer 701..838 45/193 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 798..822 9/72 (13%)
TSP1 846..895 CDD:214559 14/59 (24%)
TSP1 897..950 CDD:214559 22/43 (51%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 118 1.000 Domainoid score I5848
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100241
Panther 1 1.100 - - O PTHR13723
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.820

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