DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and ADAMTS14

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_631894.2 Gene:ADAMTS14 / 140766 HGNCID:14899 Length:1226 Species:Homo sapiens


Alignment Length:1131 Identity:317/1131 - (28%)
Similarity:465/1131 - (41%) Gaps:230/1131 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   266 NSFLKESASAFAMTGTYRNMSNEIW----DPHPQY-NLNVFGRQLHLVLRQDASFVHNHSMTHIR 325
            :|.|:.:.|.....||       :|    ..|..| |:.|||::|||.||.:...|         
Human    80 SSHLRVARSPLHPGGT-------LWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLV--------- 128

  Fly   326 ILKEGEEHPGPETEAEAEQRHL-------GCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALL 383
                   .||...|.:.:.|.|       .|.|:|.|...|.:.|::|.|.|:.|.|:|......
Human   129 -------VPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFF 186

  Fly   384 IQPVNRTSSDEV----LHRVFRKSQRNARHAVSKFEL-----GLDDFMSKL----EQVQEEEQKS 435
            |:|:.|...::.    .|.|:|:.......|....:|     ||.|..:.|    :|:.:.|   
Human   187 IEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTE--- 248

  Fly   436 KSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-EDLQPYILILMSIVSSIFADASIGNSI 499
                  ||:||   .....|::|||:.||:|:.:||| |.:|.|:|.||:||..|:.|.|:|..|
Human   249 ------RKRRH---AKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHI 304

  Fly   500 RILLVRLI------SLPNINDQTHSSNEMLKHFCQFINQS-------GYERDTAMLITRE----- 546
            .|.|||||      ||..|  :..:.:..|:..|::.:..       ....|..:.:||:     
Human   305 NIALVRLIMVGYRQSLSLI--ERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS 367

  Fly   547 ------PICGSVPGKICHMLGLAELGTVCSSSSCSIVQDTGLPTAFTMAHELGHILNMNHD-DDD 604
                  |:.|     :||.|           .||::..:.|..:||.:|||.||:|.|.|| ..:
Human   368 GMQGYAPVTG-----MCHPL-----------RSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGN 416

  Fly   605 KCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSC-LETSVGAHIPYGTE 668
            .|      .:...:..:|:.::....|.:.||:||:..:|.:|...|  | |:.......|...|
Human   417 GC------ADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYD--CLLDDPFDPAWPQPPE 473

  Fly   669 RLPGEIYSLDAQCQLSFGNDFGYC---PTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSS 730
             |||..||:|.||:..||:.:..|   .|.|.||:|||:..  ::...|.:...|..|||.| :.
Human   474 -LPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHP--DNPYFCKTKKGPPLDGTEC-AP 534

  Fly   731 GHWCQRGKCV--SNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGS 793
            |.||.:|.|:  |.:..||:  :|||..||.|..||.:|||||:...|.||.|.|..||:.|.|.
Human   535 GKWCFKGHCIWKSPEQTYGQ--DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGP 597

  Fly   794 RKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYEKD----ACKLFCRMDMK 854
            ..:|:.||:.:||....|.|.|||..   ||......|....||| ||.|    .|:|.|:....
Human   598 MFEYQVCNSEECPGTYEDFRAQQCAK---RNSYYVHQNAKHSWVP-YEPDDDAQKCELICQSADT 658

  Fly   855 VTYFMLKSMVTDGTSCAV-DSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNL 918
            .....:..:|.|||.|:. |.:..|..|.|.|.|||.|:.|:...||||||.|.|..|..|.|.|
Human   659 GDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTL 723

  Fly   919 LVSNLLGLNDGNEPNKT-LYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYP 982
                      |....:. ...:.:||.||.:|.|..........:|......:.:||.|..:...
Human   724 ----------GKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATS 778

  Fly   983 LKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTI--DKP 1045
            ..|...|:..:     ..||....  |.|.|..|...|..|.:.|::......|:|.|.|  |..
Human   779 RTFTAMGLEWE-----DAVEDAKE--SLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLL 836

  Fly  1046 PDYEA------EVEIYRWEMQAPSNCDSLCEG------------RSHRLPACISTTQGVKVAPQF 1092
            |...:      |::.|.|.:::.:.|...|.|            |.|.:           |....
Human   837 PLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHM-----------VQRHL 890

  Fly  1093 CDKSAMPKIDDRACNT-DCRLNLTVT-SISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSY 1155
            ||....||...|.||. .|...:.|| ....||.:||:||.:.:...|:...:| ....::....
Human   891 CDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSN-GTHKVMPAKA 954

  Fly  1156 CKLKFDVAYHEECREGC--------WVLSEWSTCSKSCGTGSQQREAHCYLH-NSRVSDDLCNPR 1211
            |     .....|.|..|        |.|..||.||.:||.|.|||:..|..: ||....:...|.
Human   955 C-----AGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPD 1014

  Fly  1212 TKPHLNTLIGICNTESCPTYTKSPNALAVSNWVI----GEWGECNEWCEKTRSVSCSHPYGIGC- 1271
            |       :.:|:..:|....:: :.:....|.:    |:|...:|.......:|.:.|    | 
Human  1015 T-------VQVCSLPACGGNHQN-STVRADVWELGTPEGQWVPQSEPLHPINKISSTEP----CT 1067

  Fly  1272 GSRK--------------PKDVRKCC 1283
            |.|.              |...|.||
Human  1068 GDRSVFCQMEVLDRYCSIPGYHRLCC 1093

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 33/119 (28%)
ZnMc_ADAMTS_like 455..655 CDD:239801 67/226 (30%)
Reprolysin 457..655 CDD:279729 66/224 (29%)
Salp15 <696..745 CDD:288931 18/50 (36%)
TSP1 754..806 CDD:214559 23/51 (45%)
ADAM_spacer1 937..1042 CDD:283607 24/104 (23%)
TSP1 1172..1229 CDD:214559 19/65 (29%)
GON 1495..1687 CDD:285848
ADAMTS14NP_631894.2 Pep_M12B_propep 104..206 CDD:279848 33/117 (28%)
ZnMc_ADAMTS_like 273..460 CDD:239801 60/212 (28%)
TSP1 558..610 CDD:214559 23/51 (45%)
ADAM_spacer1 717..832 CDD:283607 28/131 (21%)
Spacer 733..849 27/122 (22%)
TSP1 913..972 CDD:214559 14/64 (22%)
TSP1 978..1024 CDD:214559 16/52 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1226
DUF1180 1114..>1188 CDD:284165
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13723
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.870

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