Protein Alignment AdamTS-A and stl

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: XP_061505633.1
• Gene: stl / 1275772
• VectorBaseID: AGAMI1_011954
• Length: 1067
• Species: Anopheles gambiae
• Alignment Length: 1101
• Identity: 241/1101 - (21%)
• Similarity: 391/1101 - (35%)
• Gaps: 347/1101 - (31%)

  Fly   295 QYNLNVFGRQLHLVLRQ-------DASFVHNHSM---------THIRILKEGEEHPGPETEAEAE 343
            |:||: .||:.:..||.       |.||....|.         ::.|:||
Mosquito   104 QFNLS-DGREDNFALRLQKSDILIDESFAFIESYDNSTQLLDDSYDRVLK--------------- 152

  Fly   344 QRHLGCFYSGYVEDDPHSMVSVSLC-GGMTGYIKTSFGALLIQPVNR---TSSDEVLHRVFRKSQ 404
              :..|||.       :...:..|| |.:.|.|:|:...::|.|:..   |.:..:|:|  .|:.
Mosquito   153 --YRDCFYR-------NERAAFDLCEGSVRGLIRTNESEIVIHPLPERFGTGAHVILNR--NKTI 206

  Fly   405 RNARHAVSK--FELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYADVDN----QVYTLEVLIAV 463
            .:.....:|  ||..:::...:...|....|..:|    |.|||.:...|    .|..:|..|.:
Mosquito   207 PSDESGETKVMFEPDMNEPTRRRPTVPFYGQSQQS----RLKRHISSNHNAKVPDVLHIETAIFI 267

  Fly   464 DNSMKQFHGED--------LQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQTHSSN 520
            |..:.:...::        |..::|.:::.|..::...|:|:.|..:|.||..|.|.......|:
Mosquito   268 DKDLYRHMSKNYPKNTEAHLIRFVLAMINGVQLLYNHPSLGHPINFILKRLEILHNDPKDLRRSS 332

  Fly   521 EM---LKHFCQFINQSGYER-------------DTAMLIT-REPICGSVPGKICH-MLGLAELGT 567
            ::   |..||      |::|             |.|:::| .:....|..||:.: ::|||.:..
Mosquito   333 DIDIYLNSFC------GWQRKMNPISDADPVHFDHAVILTGLDLFVVSKNGKVSNQVVGLAPVAG 391

  Fly   568 VCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNN-NKVLHIMSSVMGIHM 630
            :|: :|||:|.:.....:.|.::||:||.|.|.||         |.:|| :..|:|||..:|  .
Mosquito   392 MCTITSSCTINEGKHFESVFVVSHEIGHNLGMRHD---------TSENNCDPSLYIMSPTLG--S 445

  Fly   631 HPWSWSKCSRHFVSEFLEKTDKSCL--ETSVGAHIPY-GTERLPGEIYSLDAQCQLSFGNDFGYC 692
            ...:||.|||::::.||:.:..:||  ....|:.:.: |..|||||.:..|.||.|.:|.|....
Mosquito   446 GKITWSSCSRNYLNTFLKTSQATCLFDRGHYGSSLDHTGEGRLPGERFDADQQCLLKYGKDSTRS 510

  Fly   693 PTD---EECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNG-- 752
            .:.   :.|:.|.|.|      ::...::.|..:||.||.. .||:.|.|||...|...|..|
Mosquito   511 KSQDLADICRDLHCQR------DRYTWTSHPALEGTNCGKL-MWCRSGVCVSKIPGLTIQSTGKH 568

  Fly   753 ---------------------------------GWGPWTPFTPCSLTC-----------GGGVQE 773
                                             .|..|:..|.|...|           ..|:::
Mosquito   569 ITAFKTIDKKTFLEGLKFASLRQDISRTLNTIPTWDSWSEPTECVSGCLYGESGRLKEGSTGLRQ 633

  Fly   774 SRRECNQPVPENGGKYCTGSRKKYRSCNTHQC----PPGSMDPREQQCYAMNGRNMNIPGVNPDT 834
            ..|:|     .:..|.|:|..:||.:|...||    ....::...|.|......:.:|.|..  .
Mosquito   634 FTRKC-----LDKRKNCSGFSRKYETCIAKQCYNIGRTTILEFSNQICGRAKEFDADIIGYG--L 691

  Fly   835 KWVPKYEKDACKLFCRMDMKVTYFMLKSMV-TDGTSCAVDS--FDK---CVNGICRPAGCDNELN 893
            :.|.:..:|:||:||  :.|......||.: .|||:|.|.:  ||.   ||:|.|....|:|..|
Mosquito   692 QKVAEDPEDSCKVFC--ETKAGVPKTKSWIYPDGTACKVQNGDFDDAYYCVSGRCEKFSCNNTSN 754

  Fly   894 SIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPD 958
            :..::|        ...|.||
Mosquito   755 NYYRID--------GALCTEV-------------------------------------------- 767

  Fly   959 QNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYT---GSSSVVEQVNTTYSWKLSRDLIVQI 1020
                                             .|||   |:|...|.|....|..|:::
Mosquito   768 ---------------------------------YQYTERSGNSIHQENVRDYKSLPLNKN----- 794

  Fly  1021 ISLDVSPSKRQDTVLLSYS-YTIDKPP------DYEAEVEIYRWEMQAPSNCDSLCE--GRSHRL 1076
             :..:.......|:..:.| ||..|||      ..:||....||..::.|..:.|.|  ||.|..
Mosquito   795 -AYPIDRRAESSTIRTALSNYTARKPPPDTEGYSSQAENTFNRWRERSSSELNRLSELQGRKHNW 858

  Fly  1077 P-------AC---------ISTTQGVKVAPQFCDKSAMPKIDDRACNTD------C-RLNLTVTS 1118
            .       :|         :|:|.|.....|.|..:.:  ..|:..:|.      | |....|:.
Mosquito   859 EVKSGCHFSCMERGKGVQIVSSTAGTNTNIQLCTANTI--ACDKVLSTYEFATQLCKRYQQKVSG 921

  Fly  1119 IS---------------ECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEEC 1168
            :|               .|..||.:...|.:.|     ..|.::.:....:.|.       |.|.
Mosquito   922 LSGIGMQIAPSIEDPDRSCRVACQDTFIRHRFY-----LVNGEQGHFPFGTRCN-------HNES 974

  Fly  1169 REGCWVLSEWSTCSKSCGTGSQQ---REAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTE 1226
            ...|       ...|....||..   .|::..|.|.|:...  ..|||.|......|..||
Mosquito   975 NRYC-------INGKCLHFGSDDIPVNESYNALPNVRIKRS--TNRTKRHFEYFAPINVTE 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	26/118 (22%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	58/227 (26%)
		ADAMTS_CR_2	671..740	CDD:465496	21/71 (30%)
		TSP1	754..806	CDD:214559	16/66 (24%)
		ADAMTS_CR_3	815..911	CDD:437068	28/101 (28%)
		TSP1	1172..1229	CDD:214559	15/58 (26%)
		TSP1_ADAMTS	1243..1282	CDD:465950
		TSP1_ADAMTS	1355..1405	CDD:465950
		GON	1493..1687	CDD:462559
stl	XP_061505633.1	None