DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and WFIKKN2

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_783165.1	Gene:	WFIKKN2 / 124857	HGNCID:	30916	Length:	576	Species:	Homo sapiens

Alignment Length:	336	Identity:	67/336 - (19%)
Similarity:	97/336 - (28%)	Gaps:	114/336 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1173 WVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNA 1237
            ||.:: |||.:.|.|   .:|...|        :.|.|          .:|.|:||        .
Human    55 WVDAQ-STCRRECET---DQECETY--------EKCCP----------NVCGTKSC--------V 89

  Fly  1238 LAVSNWVIGEWGECNEWCEKTRSVSCSHPYGIGCGSRKPKDVRKCCHIKYTSDWTDCSVQCGEGV 1302
            .|....|.|:.|                |.|:      ||:. .|.|.......::|.:..|:.|
Human    90 AARYMDVKGKKG----------------PVGM------PKEA-TCDHFMCLQQGSECDIWDGQPV 131

  Fly  1303 KRKKQSCTRVYKPDVPG-----TRKRRVYVDESYCISRKVHRPKLRTTTKSCRINCKW-NAS--- 1358
            .:.|..|.:  :|....     |...|.|:|...|      ...:.....:||.:..| |.|
Human   132 CKCKDRCEK--EPSFTCASDGLTYYNRCYMDAEAC------SKGITLAVVTCRYHFTWPNTSPPP 188

  Fly  1359 -DWRRCPADCSEEYQTRDVRCESFQGDGVEDK---------HCDAKKRP-------SKRRICNNC 1406
             :....|...|.|....|:...:...:.|...         .||...||       .:.....|.
Human   189 PETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPEITWEKQLEDRENV 253

  Fly  1407 VRRQSRV-----------------------ISQC---NCEGVEKRRDFCFNSHKGRIACPTRARV 1445
            |.|.:.|                       |..|   |..|| .|.||..:..:|..|..|....
Human   254 VMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGV-LRADFPLSVVRGHQAAATSESS 317

  Fly  1446 ERHSCTPPPHC 1456
            ...:..|...|
Human   318 PNGTAFPAAEC 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559
		ADAM_spacer1	937..1042	CDD:283607
		TSP1	1172..1229	CDD:214559	14/55 (25%)
		GON	1495..1687	CDD:285848
WFIKKN2	NP_783165.1	WAP	44..90	CDD:278522	15/64 (23%)
		KAZAL_FS	138..174	CDD:238052	7/43 (16%)
		I-set	216..304	CDD:254352	17/88 (19%)
		Ig_3	224..304	CDD:143242	16/80 (20%)
		Kunitz_BPTI	328..379	CDD:278443	1/1 (100%)
		Kunitz_BPTI	385..436	CDD:278443
		NTR_WFIKKN	455..563	CDD:239630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900