DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and Adamts1

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_033751.3	Gene:	Adamts1 / 11504	MGIID:	109249	Length:	968	Species:	Mus musculus

Alignment Length:	1079	Identity:	325/1079 - (30%)
Similarity:	471/1079 - (43%)	Gaps:	274/1079 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 LNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPG---------PETEAEAEQRHLG----- 348
            |:.||:||||.|:.|:.|:                .||         |.:||:    ||.
Mouse    83 LDAFGQQLHLKLQPDSGFL----------------APGFTLQTVGRSPGSEAQ----HLDPTGDL 127

  Fly   349 --CFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEVLHRVFRKSQRNAR--- 408
              |||||.|..||.|..::|||.|:.|..........|||....:::.:...| .:.:.:||
Mouse   128 AHCFYSGTVNGDPGSAAALSLCEGVRGAFYLQGEEFFIQPAPGVATERLAPAV-PEEESSARPQF 191

  Fly   409 HAVSKFELG--------LDDFMSKLEQVQEEEQKSKSR------------KLN-----RKKRHYA 448
            |.:.:...|        :||........:.|.|.::::            |.:     ||||.
Mouse   192 HILRRRRRGSGGAKCGVMDDETLPTSDSRPESQNTRNQWPVRDPTPQDAGKPSGPGSIRKKRF-- 254

  Fly   449 DVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISL---- 509
             |.:..| :|.::..|.||..|||..|:.|:|.|.|:.:..:...||.|||.:::|:::.:
Mouse   255 -VSSPRY-VETMLVADQSMADFHGSGLKHYLLTLFSVAARFYKHPSIRNSISLVVVKILVIYEEQ 317

  Fly   510 --PNINDQTHSSNEMLKHFCQFINQ--SGYER-----DTAMLITREPICGSVPGKICHMLGLAEL 565
              |.:   |.::...|::||.:..|  |..:|     |||:|.||:.:|||   ..|..||:|::
Mouse   318 KGPEV---TSNAALTLRNFCSWQKQHNSPSDRDPEHYDTAILFTRQDLCGS---HTCDTLGMADV 376

  Fly   566 GTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIH 629
            ||||. |.|||:::|.||..|||.||||||:.||.|||...|........::   |:|:|::...
Mouse   377 GTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKHCASLNGVSGDS---HLMASMLSSL 438

  Fly   630 MHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP- 693
            .|...||.||.:.|:.||:.....||.......|...:: |||.:|..:.|||.:||.:..:||
Mouse   439 DHSQPWSPCSAYMVTSFLDNGHGECLMDKPQNPIKLPSD-LPGTLYDANRQCQFTFGEESKHCPD 502

  Fly   694 TDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSN---KHGYGRQVNGGWG 755
            ....|..|||..|||.. ..|.:.:.||||||.|| .|.||..||||:.   || :...|:|.||
Mouse   503 AASTCTTLWCTGTSGGL-LVCQTKHFPWADGTSCG-EGKWCVSGKCVNKTDMKH-FATPVHGSWG 564

  Fly   756 PWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDP-REQQCYA 819
            ||.|:..||.|||||||.:.|||:.|||:||||||.|.|.:|||||...||..:... ||:||.|
Mouse   565 PWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFREEQCEA 629

  Fly   820 MNGRNMNIPGVNPDTKWVPKY----EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVN 880
            .|..:....|..|..:|.|||    .||.|||.|.......:|:|:..|.|||.|:.||...||.
Mouse   630 HNEFSKASFGNEPTVEWTPKYAGVSPKDRCKLTCEAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQ 694

  Fly   881 GICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKG 945
            |.|..||||..::|..|.||||||.|...||.:::| ::.|...|.:|          :..||.|
Mouse   695 GQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKMSG-IVTSTRPGYHD----------IVTIPAG 748

  Fly   946 ASNIII---TQRGYPDQ-NFIVLTDDRDNELLNGKF-LKTYPLKFVYAGVTMQYTGSSSVVEQVN 1005
            |:||.:   .|||..:. :|:.:.......:|||.| |.|......|.|..::|:|||:.:|::.
Mouse   749 ATNIEVKHRNQRGSRNNGSFLAIRAADGTYILNGNFTLSTLEQDLTYKGTVLRYSGSSAALERIR 813

  Fly  1006 TTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCE 1070
             ::| .|...|.:|::.:
Mouse   814 -SFS-PLKEPLTIQVLMV----------------------------------------------- 829

  Fly  1071 GRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKT 1135
              .|.|...|..|..:|                                           .:.::
Mouse   830 --GHALRPKIKFTYFMK-------------------------------------------KKTES 849

  Fly  1136 YACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHN 1200
            :..:.||:.                            ||:.||..|||:||:|.|:|...|...|
Mouse   850 FNAIPTFSE----------------------------WVIEEWGECSKTCGSGWQRRVVQCRDIN 886

  Fly  1201 SRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWC---EKTRSVS 1262
            ...:.: |....||        .:|..|..       |...:|.:|:|..|::.|   .|.|::.
Mouse   887 GHPASE-CAKEVKP--------ASTRPCAD-------LPCPHWQVGDWSPCSKTCGKGYKKRTLK 935

  Fly  1263 C-SHPYGI----GCGS-RKPKDVRKCCHIKYTSDWTDCS 1295
            | ||..|:    .|.. :|||.....|.:      |.||
Mouse   936 CVSHDGGVLSNESCDPLKKPKHYIDFCTL------TQCS 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	34/111 (31%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	77/213 (36%)
		Reprolysin	457..655	CDD:279729	76/211 (36%)
		Salp15	<696..745	CDD:288931	24/51 (47%)
		TSP1	754..806	CDD:214559	33/51 (65%)
		ADAM_spacer1	937..1042	CDD:283607	27/109 (25%)
		TSP1	1172..1229	CDD:214559	18/56 (32%)
		GON	1495..1687	CDD:285848
Adamts1	NP_033751.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Pep_M12B_propep	70..194	CDD:279848	38/131 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..253		12/76 (16%)
		Cysteine switch. /evidence=ECO:0000250	204..211		0/6 (0%)
		Reprolysin	259..468	CDD:279729	79/218 (36%)
		ZnMc_ADAMTS_like	259..464	CDD:239801	77/214 (36%)
		ADAM_CR	469..549	CDD:301627	35/82 (43%)
		ADAM_CR	530..699	CDD:301627	83/170 (49%)
		TSP1	563..615	CDD:214559	33/51 (65%)
		Spacer	726..850		36/228 (16%)
		ADAM_spacer1	726..843	CDD:283607	35/178 (20%)
		TSP1	857..911	CDD:214559	20/97 (21%)
		TSP1	912..>954	CDD:214559	12/41 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8232
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44060
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820