DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and ADAMTS6

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_922932.2	Gene:	ADAMTS6 / 11174	HGNCID:	222	Length:	1117	Species:	Homo sapiens

Alignment Length:	1307	Identity:	354/1307 - (27%)
Similarity:	542/1307 - (41%)	Gaps:	333/1307 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 EHSAFVMPTKVYNYSLSEADLIYESKRNSDIN-SFLKESASAFAMTGTYRNMSNEIWDP-HPQ-- 295
            ||....:|.:|                  |.| :||     :|.:.....:......|| .||
Human    40 EHYQLTIPIRV------------------DQNGAFL-----SFTVKNDKHSRRRRSMDPIDPQQA 81

  Fly   296 -----YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYV 355
                 :.|:.:|:..||.|..:..||..    |..:...|::  ||:.:.:...   .|.|:||:
Human    82 VSKLFFKLSAYGKHFHLNLTLNTDFVSK----HFTVEYWGKD--GPQWKHDFLD---NCHYTGYL 137

  Fly   356 EDD-PHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEV--------LHRVFRKSQRNARHAV 411
            :|. ..:.|::|.|.|:.|.|.|......|:|:..|:.|..        .|.:::||....||..
Human   138 QDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLY 202

  Fly   412 SKFELGLDDF--MSKLEQVQEEEQKSKSRKLNRKKRHY-----ADVDNQVYTLEVLIAVDNSMKQ 469
            .....|:.||  ..|...:.:....|.|..:|....|:     ..::..|   |.|:..|..|..
Human   203 DHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFV---ETLVVADKMMVG 264

  Fly   470 FHG-EDLQPYILILMSIVSSIFADASIGNSIRILLVRLISL----PNINDQTHSSNEMLKHFCQF 529
            :|| :|::.|||.:|:||:.::.|:|:||.:.|::.|||.|    ||: :..|.:::.|..||::
Human   265 YHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNL-EINHHADKSLDSFCKW 328

  Fly   530 -------------INQSGY-ERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQD 579
                         |.::|. ..|.|:||||..|| :...|.|..||||.:..:|. ..||||.:|
Human   329 QKSILSHQSDGNTIPENGIAHHDNAVLITRYDIC-TYKNKPCGTLGLASVAGMCEPERSCSINED 392

  Fly   580 TGLPTAFTMAHELGHILNMNHDD-DDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFV 643
            .||.:|||:|||:||...||||. .:.|     ....::...:|::.:..:.:|:|||.|||.::
Human   393 IGLGSAFTIAHEIGHNFGMNHDGIGNSC-----GTKGHEAAKLMAAHITANTNPFSWSACSRDYI 452

  Fly   644 SEFLEKTDKSCLETSVGAHIPYGTERL-----PGEIYSLDAQCQLSFGNDFGYCPTDEECKRLWC 703
            :.||:....:||:..     |...:.|     ||::|..|.||:..:|.....|...|.|:.|||
Human   453 TSFLDSGRGTCLDNE-----PPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWC 512

  Fly   704 NRTSGNSNEQCASSNLPWADGTPCGSSGH----WCQRGKCVSNKHGYG---RQVNGGWGPWTPFT 761
            .    :.:.:|.::::|.|:||.| .:|:    ||.:|.||.    :|   :.::||||||:.:.
Human   513 L----SKSNRCVTNSIPAAEGTLC-QTGNIEKGWCYQGDCVP----FGTWPQSIDGGWGPWSLWG 568

  Fly   762 PCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMN 826
            .||.||||||..|.|.|:.|.|..|||||.|.||:||||||..||.||.|.||:||...:    |
Human   569 ECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFD----N 629

  Fly   827 IPGVNPDTKWVPKYEKDA---CKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGC 888
            :|.......|.| |....   |.|.|..:....|......|.|||.|..||.|.|:||.|:..||
Human   630 MPFRGKYYNWKP-YTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGC 693

  Fly   889 DNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQ 953
            ||.|.|.|:.|:|.||.|...||..:.|        ..|| :.|......|.:||:|:.:|.:.:
Human   694 DNILGSDAREDRCRVCGGDGSTCDAIEG--------FFND-SLPRGGYMEVVQIPRGSVHIEVRE 749

  Fly   954 RGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQY---TGSSSVVEQVNTTYSWKLSRD 1015
            ... .:|:|.|..:.|:..:||.:...:|.||..||....|   |.....:|.:..|     |.:
Human   750 VAM-SKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPT-----SEN 808

  Fly  1016 LIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACI 1080
            |||.::       .::..:.:.|.:.:
Human   809 LIVMVL-------LQEQNLGIRYKFNV-------------------------------------- 828

  Fly  1081 STTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNM 1145
                                                 .|:...:...|:|           ||
Human   829 -------------------------------------PITRTGSGDNEVG-----------FT-- 843

  Fly  1146 QRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYL--HNSRVSDDLC 1208
                                       |....||.||.:|..|.|::|..|..  .||.|.::.|
Human   844 ---------------------------WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYC 881

  Fly  1209 NPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCE---KTRSVSCSHPYG-- 1268
            :|.:||..|.  ..||||.||           ..|.||:|.||::.|:   :||:|.|....|
Human   882 DPDSKPPENQ--RACNTEPCP-----------PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPS 933

  Fly  1269 -------IGCGSRKPKDVRKC----CHIKYTS-DWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTR 1321
                   .||.:.:|.:...|    |..::.: ||::|:.:||.|.|.:...|.   ..|:..|.
Human   934 EEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCK---SSDLSKTF 995

  Fly  1322 KRRVYVDESYCISRKVHRPKLRTTTKSCRINC--------KWNASDWRRCPADCSEEYQTRDVRC 1378
            ......:||        :|.:       ||.|        :|...||.:|.|.|....|.|.|:|
Human   996 PAAQCPEES--------KPPV-------RIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQC 1045

  Fly  1379 ESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVISQC-NCEGVEK--------RRDFCFNSHK 1434
            .|:.|....|  |....||...:.|.:  :..|..||.. .|:.|.|        :..||..::.
Human  1046 LSYTGQASSD--CLETVRPPSMQQCES--KCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYF 1106

  Fly  1435 GRIACPT 1441
            .::.|.|
Human  1107 RQMCCKT 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	30/116 (26%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	75/220 (34%)
		Reprolysin	457..655	CDD:279729	75/218 (34%)
		Salp15	<696..745	CDD:288931	17/52 (33%)
		TSP1	754..806	CDD:214559	31/51 (61%)
		ADAM_spacer1	937..1042	CDD:283607	25/107 (23%)
		TSP1	1172..1229	CDD:214559	22/58 (38%)
		GON	1495..1687	CDD:285848
ADAMTS6	NP_922932.2	Pep_M12B_propep	69..190	CDD:279848	32/129 (25%)
		Reprolysin	250..468	CDD:279729	78/232 (34%)
		ZnMc_ADAMTS_like	250..465	CDD:239801	77/224 (34%)
		TSP1	561..613	CDD:214559	31/51 (61%)
		Spacer	717..843		32/233 (14%)
		ADAM_spacer1	719..829	CDD:283607	29/206 (14%)
		TSP1	848..900	CDD:214559	21/53 (40%)
		TSP1	902..960	CDD:214559	16/57 (28%)
		TSP1	1022..1069	CDD:214559	16/48 (33%)
		PLAC	1083..1115	CDD:285849	7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42007
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720