DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and ADAMTS5

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_008969.2 Gene:ADAMTS5 / 11096 HGNCID:221 Length:930 Species:Homo sapiens


Alignment Length:1111 Identity:307/1111 - (27%)
Similarity:439/1111 - (39%) Gaps:278/1111 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 LLG----MLIMFHLGLRSAHKGQEELPQSTHPLANSPPATPATLHPRRLDNDTSTDHEPPDGLDD 230
            |||    :|..|.|.|  |..|....|  ....|..||...|...|||...:...:...|.|   
Human     2 LLGWASLLLCAFRLPL--AAVGPAATP--AQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPG--- 59

  Fly   231 LDEEEHSAFVMPTKVYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQ 295
               ..|.                  :.:.:|:..:...:.:..|.....|               
Human    60 ---HPHP------------------LAQRRRSKGLVQNIDQLYSGGGKVG--------------- 88

  Fly   296 YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQR-HLGCFYSGYVEDDP 359
            |.:...||:..|.|.:|.|           :...|....|..|.|....| |  |||.|.|:..|
Human    89 YLVYAGGRRFLLDLERDGS-----------VGIAGFVPAGGGTSAPWRHRSH--CFYRGTVDGSP 140

  Fly   360 HSMVSVSLCGGMTGYIKTSFGALLIQPVNRTS-SDEVLHRVFRKSQRNARHAVSK----FEL--- 416
            .|:....||||:.|:.........::|:.|.. ::|...||:........|..::    ||.   
Human   141 RSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPP 205

  Fly   417 ------------------------GLDDFMSKL--EQVQEEEQKSKSRKLNRKKRHYADVDNQVY 455
                                    |.....|:|  :........|..:...|::|.......|| 
Human   206 RASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQV- 269

  Fly   456 TLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQTHSSN 520
              |:|:..|.||.:.:|..||.|:|.|.||.:.:::.|||.|.||:.:|:::.|.:.:.....|.
Human   270 --ELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSK 332

  Fly   521 E---MLKHFCQF---INQSGYER----DTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSC 574
            .   .||:||::   .||.|.:.    |.|:|.|||.:||.   ..|..||:|::||:|| ..||
Human   333 NAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGH---HSCDTLGMADVGTICSPERSC 394

  Fly   575 SIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCS 639
            ::::|.||..|||:|||:||:|.::|||...|........:.:   :|||::........||||:
Human   395 AVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKR---LMSSILTSIDASKPWSKCT 456

  Fly   640 RHFVSEFLEKTDKSCLETSVGAHIP----YGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEECKR 700
            ...::|||:....:||     ..:|    .|.|.|||:.|....||.|:||.::..||..:.|.|
Human   457 SATITEFLDDGHGNCL-----LDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCAR 516

  Fly   701 LWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCV--SNKHGYGRQVNGGWGPWTPFTPC 763
            ||| .........|.:..||..:||||| .|..|.:||||  :.|..|....:|.||.|..:..|
Human   517 LWC-AVVRQGQMVCLTKKLPAVEGTPCG-KGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQC 579

  Fly   764 SLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIP 828
            |.:||||||.:.|.||.|.|.|.|:||||.|..||||:...|||.....|.:||.|.||...:..
Human   580 SRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAK 644

  Fly   829 GVNPDTKWVPKY----EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCD 889
            ||....:|||||    ..|.|||.||......|.:....|||||.|.:.|...||.|.|...|||
Human   645 GVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCD 709

  Fly   890 NELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQR 954
            ..:.|..:.||||||.|.|.:|.::.|..           |:.:|....|.|||:||::|.:.|.
Human   710 GIIGSKLQYDKCGVCGGDNSSCTKIVGTF-----------NKKSKGYTDVVRIPEGATHIKVRQF 763

  Fly   955 GYPDQN----FIVLTDDRDNELLNGKF-LKTYPLKFVYAGVTMQYTGSS-----------SVVEQ 1003
            ...||.    ::.|.......|:|||: :.|........|..|.|:|.|           |..::
Human   764 KAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKE 828

  Fly  1004 VNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSL 1068
            :           |||||::.|  |:|..|   :.||:                            
Human   829 I-----------LIVQILATD--PTKPLD---VRYSF---------------------------- 849

  Fly  1069 CEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTRE 1133
                                   |..|.:.||::            :|||               
Human   850 -----------------------FVPKKSTPKVN------------SVTS--------------- 864

  Fly  1134 KTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYL 1198
                        ..||           .|..|..  :..||...|..||::|.||...|...|..
Human   865 ------------HGSN-----------KVGSHTS--QPQWVTGPWLACSRTCDTGWHTRTVQCQD 904

  Fly  1199 HNSRVS 1204
            .|.:::
Human   905 GNRKLA 910

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 27/109 (25%)
ZnMc_ADAMTS_like 455..655 CDD:239801 73/210 (35%)
Reprolysin 457..655 CDD:279729 73/208 (35%)
Salp15 <696..745 CDD:288931 20/50 (40%)
TSP1 754..806 CDD:214559 27/51 (53%)
ADAM_spacer1 937..1042 CDD:283607 33/120 (28%)
TSP1 1172..1229 CDD:214559 11/33 (33%)
GON 1495..1687 CDD:285848
ADAMTS5NP_008969.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..69 11/70 (16%)
Pep_M12B_propep 67..168 CDD:307618 28/128 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..231 0/24 (0%)
Cysteine switch. /evidence=ECO:0000250 207..214 0/6 (0%)
ZnMc_ADAMTS_like 269..473 CDD:239801 76/217 (35%)
TSP1 570..622 CDD:214559 27/51 (53%)
Spacer 732..874 46/269 (17%)
ADAM_spacer1 732..852 CDD:310520 37/197 (19%)
TSP1 879..930 CDD:214559 11/32 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 55 1.000 Domainoid score I11114
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100241
Panther 1 1.100 - - O PTHR13723
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.820

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