DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and ADAMTS13

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_620594.1 Gene:ADAMTS13 / 11093 HGNCID:1366 Length:1427 Species:Homo sapiens


Alignment Length:1420 Identity:332/1420 - (23%)
Similarity:503/1420 - (35%) Gaps:368/1420 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   438 RKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRIL 502
            |:..|::|    ....:..||:|:||...:.|.|.||.:.|:|..::|.:.:..|.|:|...|:.
Human    67 RQRQRQRR----AAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVH 127

  Fly   503 LVRLISL------PNINDQTHSSNEMLKHFCQFIN-----QSGYERDTAMLITREPICGSVPGKI 556
            ||:::.|      |||.....||...:..:.|.||     ..|: .|..:.|||..:  .:|...
Human   128 LVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGH-ADLVLYITRFDL--ELPDGN 189

  Fly   557 CHMLGLAELGTVCSSS-SCSIVQDTGLPTAFTMAHELGHILNMNHD--DDDKCMPYVTRQNNNKV 618
            ..:.|:.:||..||.: ||.|.:|||.....|:|||:||...:.||  ....|.|..        
Human   190 RQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSG-------- 246

  Fly   619 LHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL------ETSVGAHIPYGTERLPGEIYSL 677
             |:|:|.........:||.|||..:...|......|:      :.....|.|   :..||..||.
Human   247 -HVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPP---DAQPGLYYSA 307

  Fly   678 DAQCQLSFGNDFGYCPTDEE----CKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGK 738
            :.||:::||.....|....|    |:.|.|: |.......|:...:|..|||.||.. .||.:|:
Human   308 NEQCRVAFGPKAVACTFAREHLDMCQALSCH-TDPLDQSSCSRLLVPLLDGTECGVE-KWCSKGR 370

  Fly   739 CVSNKHGYGRQ---------VNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSR 794
            |        |.         |:|.|..|.|.:|||.:|||||...||:||.|.|..||:.|.|:.
Human   371 C--------RSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGAD 427

  Fly   795 KKYRSCNTHQCPPGSMDPREQQCYAMNGRNM-NIPGVNPDTKW---VPKYEKDA-CKLFCRMDMK 854
            .:...|||..|....::...|||...:|:.: :.||......|   ||..:.|| |:..||. :.
Human   428 LQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRA-IG 491

  Fly   855 VTYFMLK-SMVTDGTSCAVD------SFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCH 912
            .::.|.: ....|||.|...      :...||:|.||..|||..::|....|:|.||.|.|.||.
Human   492 ESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCS 556

  Fly   913 EVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKF 977
            ...|:...            .:...|||                    |:.:|.:     |...:
Human   557 PRKGSFTA------------GRAREYVT--------------------FLTVTPN-----LTSVY 584

  Fly   978 LKTYPLKFVYAGVTM--QYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSY 1040
            :..:...|.:..|.:  :|..:..:....||||...|....:...::|......|.:.:      
Human   585 IANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEI------ 643

  Fly  1041 TIDKPPDYEAEVEIYR--------------------------WEMQAPSNCDSLCEGRSHRLP-- 1077
            .|..|...:|::::||                          |...|.....|:..|...|..  
Human   644 RIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNY 708

  Fly  1078 ACISTTQGVKVAPQFCDKSAMPKIDDRACNTD-CRLNLTVTSISECSAACGELGTREKTYACVQT 1141
            :|:...:...|....|..|..|.....||..: |.....|.....|||:||. |.||:...||:.
Human   709 SCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGG-GLRERPVRCVEA 772

  Fly  1142 FTNMQRSNIVDMSYCKLKFDVAYHEECREGC--------WVLSEWSTCSKSCGTGSQQREAHCYL 1198
                |.|.:..:...:.:..........|.|        |.:||.|:|:.:.|.|.......|. 
Human   773 ----QGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV- 832

  Fly  1199 HNSRVSDDLCNPRTK---------PHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEW 1254
               ..:|.|..|.|:         |.....:|:    |||......:|.:........||.....
Human   833 ---PGADGLEAPVTEGPGSVDEKLPAPEPCVGM----SCPPGWGHLDATSAGEKAPSPWGSIRTG 890

  Fly  1255 CEKTR-----SVSCSHPYGIG---------------------CG-SRKPKDVRKCCH-IKYTSDW 1291
            .:...     :.|||...|.|                     || :.||...|:.|. :...:.|
Human   891 AQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW 955

  Fly  1292 ----TDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRIN 1352
                ..|||.||.||.|:...|.|.:..|    ....:.:| :.|  :.:.||:   ..::|.:.
Human   956 QYKLAACSVSCGRGVVRRILYCARAHGED----DGEEILLD-TQC--QGLPRPE---PQEACSLE 1010

  Fly  1353 -C--KWNASDWRRCPADCSEEYQTRDVRCESF-QGDGVE--DKHCDAKKRPSKRRICNNCVRRQS 1411
             |  :|.......|.|.|......|.|.|... ||..||  :..|.|..||.....|        
Human  1011 PCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC-------- 1067

  Fly  1412 RVISQC--------------NC-EGVEKRRDFCFNSHKGRIACPTRARVERHSCTPPP----HCR 1457
             :|:.|              :| :|:::|||.|...   :...|..|...:|  .|.|    .|.
Human  1068 -LIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGP---QAQAPVPADFCQH--LPKPVTVRGCW 1126

  Fly  1458 RRSAIGSSISSR-PRGTGVSSSRSLNSIGG-----SRNRGTPRSCADLKEMHGYNKDGNYQLEVR 1516
            ....:|....|. |.....:..|:..:..|     |:.||.                        
Human  1127 AGPCVGQGTPSLVPHEEAAAPGRTTATPAGASLEWSQARGL------------------------ 1167

  Fly  1517 SRMVHIYCHGMNSRTPQ-EYVNVDPQENYSIYYEYRTKQTNSCPPESRGHEYYNDQNSGRTHFRK 1580
                      :.|..|| ..:...||||        :.|:::|               ||.|...
Human  1168 ----------LFSPAPQPRRLLPGPQEN--------SVQSSAC---------------GRQHLEP 1199

  Fly  1581 LRLNITDLRIMDNDFKFADSRGLAQKLGSAGDCYNRIGQCPQGDF--------SINMKDTDFSIR 1637
            ...              .|.||..|     .||...||: |.|:.        |:|....|..:.
Human  1200 TGT--------------IDMRGPGQ-----ADCAVAIGR-PLGEVVTLRVLESSLNCSAGDMLLL 1244

  Fly  1638 PGTV-WRMHGQYSVMKRISEF----DTTTQMRRGFCGGYCG------GCYIAPDS 1681
            .|.: ||     .:.:::.:.    .|.|.:.|..||...|      |..:||::
Human  1245 WGRLTWR-----KMCRKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPET 1294

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848
ZnMc_ADAMTS_like 455..655 CDD:239801 63/213 (30%)
Reprolysin 457..655 CDD:279729 63/211 (30%)
Salp15 <696..745 CDD:288931 16/52 (31%)
TSP1 754..806 CDD:214559 24/51 (47%)
ADAM_spacer1 937..1042 CDD:283607 16/106 (15%)
TSP1 1172..1229 CDD:214559 16/73 (22%)
GON 1495..1687 CDD:285848 37/207 (18%)
ADAMTS13NP_620594.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..70 1/2 (50%)
ZnMc_ADAMTS_like 80..283 CDD:239801 64/214 (30%)
TSP1 387..439 CDD:214559 24/51 (47%)
Cysteine-rich 440..556 35/116 (30%)
Cell attachment site. /evidence=ECO:0000255 498..500 0/1 (0%)
Spacer 556..685 22/171 (13%)
ADAM_spacer1 559..680 CDD:283607 22/163 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.780

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