DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and adamtsl5

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_005166548.1	Gene:	adamtsl5 / 101886605	ZFINID:	ZDB-GENE-161017-76	Length:	538	Species:	Danio rerio

Alignment Length:	482	Identity:	124/482 - (25%)
Similarity:	182/482 - (37%)	Gaps:	128/482 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   754 WGPWTPFTPCSLTCGGGVQESRRECNQPVPEN--GGKYCTGSRKKYRSCNTHQCPPGSMDPREQQ 816
            |..|..::.||.:||||.....|.|   :..|  ||. |.|..::|:.||:.:||..|||.||.|
Zfish    55 WASWGGWSVCSRSCGGGASVRTRTC---MTRNLVGGP-CPGDTRQYKICNSKECPADSMDFRELQ 115

  Fly   817 CYAMNGRNMNIPGVNPDTKWVPKY-EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVN 880
            |.|.|.|.: :.|  ....|...: ..|.|:|.| :.:...::.....|.|||.|..|....|||
Zfish   116 CKAFNDRPL-VAG--SSFHWTTFHGGSDPCELSC-LAIGHNFYYNFGRVLDGTPCQSDQGTVCVN 176

  Fly   881 GICRPAGCDNELNSIAKLDKCGVCEGRNDTC--HEVTGNLLVSNLLGLNDGNEPNKTLY---YVT 940
            |.|...|||....|..:.|.|.||.|.|.||  |.   ::..||  |.|:|      |:   .||
Zfish   177 GKCLKPGCDLIFGSQQQEDACMVCGGHNSTCLHHR---SVYQSN--GQNNG------LFGYSEVT 230

  Fly   941 RIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVN 1005
            .||.||::|.:|..   .:|::.|.:.....::||.:....|.::..||..:||..|:...|...
Zfish   231 MIPAGATHIRVTDN---SRNYLALQNGHSQFVINGNWKINVPGEYSVAGTKLQYRRSADTWESFE 292

  Fly  1006 TTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCE 1070
            .  |.....||.:.::|.|....       :.|.|.:  |||..|                 |..
Zfish   293 V--SGPTQEDLHIMVLSTDKKSG-------IEYEYWL--PPDRYA-----------------LYH 329

  Fly  1071 GRSH------------------RLPACISTTQGVKVAPQFC------------------------ 1093
            |||.                  |.....:||........|.
Zfish   330 GRSQLRQTHHTANHLPFEPPTTRTTTTTTTTTAQPTTRAFFWGPAAQWPFQPPYQQQPVPRLERD 394

  Fly  1094 --DKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYC 1156
              .::.:|:|..|.   .|         .:|....|: |.|::.| |.:.|  :.|..:::..|.
Zfish   395 ENRRNRLPEIHRRG---HC---------GKCRRVRGK-GERQRQY-CQKDF--VFRVKVLEKVYL 443

  Fly  1157 --KLKFDV--------AYHEECREGCW 1173
              :.::||        .|..|.||..|
Zfish   444 GEETRYDVQIIHTYRNRYRVEHREFLW 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559	18/53 (34%)
		ADAM_spacer1	937..1042	CDD:283607	26/107 (24%)
		TSP1	1172..1229	CDD:214559	1/2 (50%)
		GON	1495..1687	CDD:285848
adamtsl5	XP_005166548.1	TSP1	55..105	CDD:214559	18/53 (34%)
		ADAM_spacer1	219..321	CDD:283607	29/121 (24%)
		NTR	426..519	CDD:280015	12/48 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900