Protein Alignment AdamTS-A and adamts17

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: XP_073764157.1
• Gene: adamts17 / 101884120
• ZFINID: ZDB-GENE-121030-7
• Length: 1134
• Species: Danio rerio
• Alignment Length: 1193
• Identity: 323/1193 - (27%)
• Similarity: 506/1193 - (42%)
• Gaps: 235/1193 - (19%)

  Fly   291 DP----HPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFY 351
            ||    |....|..||::|:|.|::||||     :|...:.:|..|....:.|:..:.|.  |||
Zfish    63 DPQQEDHLFLRLPAFGKELYLELQRDASF-----LTEGFVTEERREEGSVQHESLPKVRR--CFY 120

  Fly   352 SGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEVL---HRVFRKSQRNARHAVSK 413
            :|.:.:...|.||:..|||:||.::|:...|.|:||.: ::|...   |||.|:...:.......
Zfish   121 TGAILNHTDSFVSLDTCGGLTGLVQTAEERLFIEPVGQ-AADSFSGWEHRVIREKHSSPDGPAPA 184

  Fly   414 FELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-EDLQP 477
            .: |.:.|...:.. :::|::.:..:..|.:|:...:..: ||:|.|:..|.:|.|:|| |..|.
Zfish   185 AD-GREQFCQSIHD-KKKEKRPRGAEQVRGRRNAIRLSRE-YTVETLVVADANMVQYHGAEAAQR 246

  Fly   478 YILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQT---HSSNEMLKHFCQFINQSGYER-- 537
            ::|.:|::|.::|...|:|..:.|.:.:|:.|.|..::.   |...:.|:.||.:.::....|
Zfish   247 FLLTVMNMVYNMFQHQSLGLRLNIRVTKLVLLHNRPEKLKVGHHGEKALESFCHWQHEEYGARYL 311

  Fly   538 ---------------DTAMLITREPICGSVPGKICHMLGLAELGTVCSSS-SCSIVQDTGLPTAF 586
                           |.|:|:||...|.. ..:.|..:|:|.||..|||. .|.:.:|.||..||
Zfish   312 GNNHVPGSRDDPPPVDAAVLVTRTDFCVH-KDEPCDTVGIAYLGGTCSSKRKCVLAEDNGLNLAF 375

  Fly   587 TMAHELGHILNMNHDDDD-KCMPYVTRQNNNKVLHIMSS--VMGIHMHPWSWSKCSRHFVSEFLE 648
            |:||||||.:.|:||||. .|..:         .||||.  |.|.:....|||.|||..:.:||.
Zfish   376 TIAHELGHNMGMSHDDDHASCTGH---------SHIMSGEWVKGRNPSDLSWSTCSRDDLEKFLR 431

  Fly   649 KTDKSCL-----ETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEE---CKRLWCNR 705
            .....||     .......:|   .:|||..||.|.|||:.||.:..:| ||.|   |..||| .
Zfish   432 SKASGCLLHTDPRNRYLVRLP---AKLPGMHYSADEQCQILFGTNATFC-TDMEHLMCAGLWC-L 491

  Fly   706 TSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGG 770
            ..|:::  |.:...|..|||.||:. .||:.|:||| |....:.|:|.|.||:.::.||.|||.|
Zfish   492 VEGDTS--CKTKLDPPLDGTECGAD-KWCRAGECVS-KTPIPQHVDGDWSPWSTWSMCSRTCGTG 552

  Fly   771 VQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTK 835
            .:..:|:|:.|.|..|||||..:..:::.|....|..|....|:|||.:...:     .......
Zfish   553 ARFRQRKCDNPPPGPGGKYCQKASVEHKVCEGPPCTKGLPTFRDQQCQSHERQ-----ASKKSQM 612

  Fly   836 WVPKYEKD-ACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLD 899
            |....:.: .|.|:|......:..::...|.|||.|.....|.||||.|:..|||..:.|.||.|
Zfish   613 WTAVIDDEKPCALYCTPVGSDSPVLVAERVLDGTPCGPYESDLCVNGKCQKIGCDGIIGSSAKED 677

  Fly   900 KCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTR---------------------IP 943
            :||||.|...:|..:.|:...|.      |..|:.....|:.                     ||
Zfish   678 RCGVCNGDGKSCRIIKGDFNHSK------GMVPHSLCKKVSTCVMSKPRAVLKCFSCYIEAAVIP 736

  Fly   944 KGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTY 1008
            .||..|.:.: ..|..:|:.|.|. ....:|..:....|.:|..||.|::|. ...:.|:::...
Zfish   737 VGARRIKVVE-DKPSHSFLALKDS-SKRSINNDWKIELPGEFELAGTTVRYV-RRGLWEKMSAKG 798

  Fly  1009 SWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTI------DKPPDYEAEVE-IYRWEMQAPSNCD 1066
            ..|....|:|.:.        ...|..:.|.||:      :...|...|.| :|.|...:..:|.
Zfish   799 PTKTPLHLMVLLF--------HDQTYGIHYEYTVALNHSQENSSDLVKEPEHMYLWTHSSWEDCS 855

  Fly  1067 SLCEGRSHR-LPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELG 1130
            ..|.|...| :.:|:          :..:|:..| ::|.:|..:   |.....|.:|
Zfish   856 VHCGGGERRTVVSCM----------RIINKTMTP-VNDSSCQVE---NKPSPQIRQC-------- 898

  Fly  1131 TREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAH 1195
                              ||....|                .||..:|:.||.:||.|.||||..
Zfish   899 ------------------NIHPCQY----------------RWVTGDWTQCSLTCGKGLQQREVG 929

  Fly  1196 C--YLHNSRV--SDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWC- 1255
            |  .|.|...  :.||....:||   ..:..|....|.|.           |...||.:|:..|
Zfish   930 CIYQLQNGTYIPTRDLYCLSSKP---ASVQHCEGRHCLTV-----------WEASEWSQCSSECG 980

  Fly  1256 --EKTRSVSCSHPYGIGCGSRKPKDVRKC-----CHIKYTSDWTDCSVQCGEGVKRKKQSCT-RV 1312
              .:.|:|:|::|:|:.....:|.:|..|     |:...|.:|:.||..||.|::.:...|. ||
Zfish   981 HGSRRRTVTCTNPHGLCDPVSRPAEVEACEDHSKCYEWKTGEWSKCSSSCGRGLQSRVVQCMHRV 1045

  Fly  1313 ---YKPDVPGTRKRRVY--VDESYCISR----KVHRPKLRTTTKSC-----RINCK--------- 1354
               :..|.|...|...|  ..:|.|.:|    .:..|:|...|..|     .:.||
Zfish  1046 SGRHGSDCPAVLKPATYRQCHQSTCNARGNINTITSPRLAALTYKCVGDQWAVYCKVIREKNLCQ 1110

  Fly  1355 ---WNASDWRRCPADCSEEYQTR 1374
               |    ::||...|.:.|..:
Zfish  1111 DMRW----YQRCCQTCRDFYTNK 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	32/98 (33%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	73/224 (33%)
		ADAMTS_CR_2	671..740	CDD:465496	29/71 (41%)
		TSP1	754..806	CDD:214559	19/51 (37%)
		ADAMTS_CR_3	815..911	CDD:437068	30/96 (31%)
		TSP1	1172..1229	CDD:214559	20/60 (33%)
		TSP1_ADAMTS	1243..1282	CDD:465950	12/41 (29%)
		TSP1_ADAMTS	1355..1405	CDD:465950	5/20 (25%)
		GON	1493..1687	CDD:462559
adamts17	XP_073764157.1	None