DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and Adamts9

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_780523.3 Gene:Adamts9 / 101401 MGIID:1916320 Length:1931 Species:Mus musculus


Alignment Length:2010 Identity:560/2010 - (27%)
Similarity:807/2010 - (40%) Gaps:626/2010 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   201 SPPATPAT----LHPRR---LDNDTSTDHEPPDGLDDLDEEEHSAFVMPTKVYNYSLSEADLIYE 258
            ||.:..|.    ||||:   |::.:..:...|..::.|.|.      .||.|:          ::
Mouse    22 SPDSAAAVRKDRLHPRQVKLLESLSEYEIASPIRVNPLGEP------FPTNVH----------FK 70

  Fly   259 SKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTH 323
            .:|.| ||| ..:...|||.:.:....|.|      .|.|:.||:|....|.....|:  ..:..
Mouse    71 RRRRS-INS-ASDPWPAFASSSSSSTSSQE------HYRLSAFGQQFLFNLTAHTGFI--APLFT 125

  Fly   324 IRILKEGEEHPGPE-----TEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALL 383
            :.:|.|    ||..     :|.|.|.||  |||.|:|.........:|||.||.|..::..|...
Mouse   126 VTLLGE----PGVNQTKLYSEEEMELRH--CFYKGHVNTKSEHTAVISLCSGMMGTFRSHDGDYF 184

  Fly   384 IQPVNRTSSDE------VLHRVFRKS--QR---NARHAVSKFELGLDDFMSKLEQVQEEEQKSKS 437
            |:|:......|      ..|.::|.|  ||   ..:||.:..||          :....:.|.|.
Mouse   185 IEPLQSVDEQEDEEEQNKPHIIYRHSTPQREPSTGKHACATSEL----------KNSHSKDKRKI 239

  Fly   438 RKLNRKKRH--------------------YADVDNQVYT----------------LEVLIAVDNS 466
            |...|:||:                    |::..|....                :||::..|:.
Mouse   240 RMRKRRKRNSLADDVALLKSGLATKVLSGYSNQTNSTRDRWNHKRTKRFLSYPRFVEVMVVADHR 304

  Fly   467 MKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLP--------NINDQTHSSNEML 523
            |..:||.:||.|||.|||||:||:.|:||||.|.|::|.|:.:.        |.|.||     .|
Mouse   305 MVLYHGANLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPYINFNAQT-----TL 364

  Fly   524 KHFCQFINQSGY----ERDTAMLITREPICGSVPGKICHMLGLAELGTVCSS-SSCSIVQDTGLP 583
            |:|||:.:...|    :.|||:|:|||.||.:...  |..||||||||:|.. .||||.:|:||.
Mouse   365 KNFCQWQHSKNYLGGIQHDTAVLVTREDICRAQDK--CDTLGLAELGTICDPYRSCSISEDSGLS 427

  Fly   584 TAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLE 648
            ||||:||||||:.||.|||.:||    ..:......|:|:..:..:.:||.||||||.:::|||:
Mouse   428 TAFTIAHELGHVFNMPHDDSNKC----KEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLD 488

  Fly   649 KTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQ 713
            .....||.....:.......:|||.:|:::.||:|.||.....||...:|:|||||...| :::.
Mouse   489 TGYGECLLNEPASRTYPLPSQLPGLLYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVDG-AHKG 552

  Fly   714 CASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRREC 778
            |.:.:.||||||.|....| |:.|.||. |...|..::|.||.|:.|..||.|||||::.:.|||
Mouse   553 CRTQHTPWADGTECEPGKH-CKFGFCVP-KEMEGPAIDGSWGGWSHFGTCSRTCGGGIKTAIREC 615

  Fly   779 NQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE-- 841
            |:|.|:||||||.|.|.|::||||..|.....|.||:||...:|::.||.|:.|..:|||||.  
Mouse   616 NRPEPKNGGKYCVGRRMKFKSCNTEPCMKQKRDFREEQCAHFDGKHFNINGLLPSVRWVPKYSGI 680

  Fly   842 --KDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVC 904
              ||.||||||:.....|:.|:..|.|||.|..|:.|.||.|:||.||||:.|||.|:.||||:|
Mouse   681 LMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHILNSKARKDKCGIC 745

  Fly   905 EGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYY----VTRIPKGASNIIITQRGY----PDQNF 961
            .|.|.:|..|.|..               .|::|    |.|||.||::|.:.|..:    .|.|:
Mouse   746 GGDNSSCKTVAGTF---------------NTVHYGYNTVVRIPAGATSIDVRQHSFSGKSEDDNY 795

  Fly   962 IVLTDDRDNELLNGKFLKTYPLKFVYAG-VTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLD- 1024
            :.|::.:...||||.|:.:...:.|..| ..::|:||.:|||::|.|.  ::..:|::|::|:. 
Mouse   796 LALSNSKGEFLLNGDFVVSMSKREVRVGSAVIEYSGSDNVVERLNCTD--RIEEELLLQVLSVGK 858

  Fly  1025 -VSPSKRQDTVLLSYSYTI---DKPPDYEAEVEIYRWEMQAP-SNCDSLCEGRSHRLPACISTTQ 1084
             .:|..|       ||:.|   |||       :.:.|....| ..|...|:|...|...|...:.
Mouse   859 LYNPDVR-------YSFNIPIEDKP-------QQFYWNSHGPWQACSKPCQGERRRKLVCTRESD 909

  Fly  1085 GVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQ-RS 1148
            .:.|:.|.||:...|.....||.|||.|...|.|.|||||.|| ||.|.....|.: ::.|. ::
Mouse   910 QLTVSDQRCDRLPQPGPVTEACGTDCDLRWHVASKSECSAQCG-LGYRTLDIHCAK-YSRMDGKT 972

  Fly  1149 NIVDMSYCKLKFDVAYHE----ECREGCWVLSEWSTCSKSCGTGSQQREA--------------- 1194
            ..||.|:|..:...:..|    ||..|.|..|.|:.||:||..|:|:|.|               
Mouse   973 EKVDDSFCSSQPRPSNQEKCSGECSTGGWRYSAWTECSRSCDGGTQRRRAICVNTRNDVLDDSKC 1037

  Fly  1195 ------------------------------------H----CYLHNSRVSDDLCNPRTKPH---- 1215
                                                |    |.....|:||.:|:|..||.    
Mouse  1038 THQEKVVVQSCNEFSCPHWKTGDWSECLVTCGKGHKHRQVWCQFGEDRLSDRMCDPEAKPEPMQT 1102

  Fly  1216 ---------------------------------LNTLIGI-----CNTESCPTYTKS-------P 1235
                                             :.|.:.:     ||..:.||.|:.       |
Mouse  1103 CQQPECAAWQAGPWGQCSVTCGQGYQLRAVKCIMGTYMSVVDDNDCNAATRPTDTQDCELASCHP 1167

  Fly  1236 NALAV-----------SNWVIGEWGECNEWCEK---TRSVSCSHPYG-----IGCGSRKPKDVRK 1281
            :.||:           :.|..|.|..|:..|.|   .|.|||....|     ..|.: .||.|.|
Mouse  1168 SILALEPRRNAQSIPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEDGSVADESACAT-LPKPVAK 1231

  Fly  1282 --C----CHIKYTSDWTDCSVQCGEGVKRKKQSCTRV---------------------------- 1312
              |    |......||:.|||.||:|...::..|...                            
Mouse  1232 EECSVTPCGQWKALDWSSCSVTCGQGKATRQVVCVNYSDHVIDRSECDPDYIPETDQDCSMSPCP 1296

  Fly  1313 -------------YKP--DVP------------------------GTRKRRVYV--DES-YCISR 1335
                         ::|  |.|                        |..:|||.|  ||: |..:.
Mouse  1297 QWTGLAHPFQNEDFRPRSDSPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTAND 1361

  Fly  1336 KVHRPK------------------------------LRT-------------------------- 1344
            .|.|.|                              :||                          
Mouse  1362 CVERIKPDEQRACESGPCPQWAYGSWGECTKLCGGGMRTRLVVCQRANGDRFPDLSCEVLDKPTD 1426

  Fly  1345 ----TTKSCRINCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRIC-- 1403
                .|.:|..:..|:...|..|...|...::.|:|.|.:..|..:|..:|....:|...|.|  
Mouse  1427 REQCNTHACPQDAAWSTGPWSSCSVSCGRGHKHRNVYCLAKDGSHLESDNCKHLPKPHGHRRCRG 1491

  Fly  1404 NNCVRRQSRVISQC--NC-EGVEKRRDFC-FNSHKG---------------RIA----CP----- 1440
            ..|.|.::...|||  :| :||::|...| ..:||.               |:.    ||     
Mouse  1492 GRCPRWKAGAWSQCSVSCGQGVQQRHVGCQIGTHKAARESECSSYSRPESERVCQASPCPLYTWR 1556

  Fly  1441 --------------TRAR-----------------------VERHSCTPPP-----------HC- 1456
                          :|.|                       .:|.||:..|           .| 
Mouse  1557 AEQWQQCTKTCGEGSRYRQVVCVAEDQSEVHSTHCDSDQRPPDRESCSLQPCEYVWITGEWSECS 1621

  Fly  1457 -------RRRSAIGSSI-----------------------SSRP---RGTGVSSSRSLNSIG--- 1485
                   |:|....|.|                       |..|   |...||::..:.:.|   
Mouse  1622 VTCGKGYRQRLVSCSEIYTGKENYEYSYQTTVNCPGAQPPSVHPCYLRDCPVSATWRVGNWGSCS 1686

  Fly  1486 -----GSRNRGT---------------------------------PRSCADLKEMHGYNKDGNYQ 1512
                 |..:|..                                 |::|.::|:::..:.||.|.
Mouse  1687 VSCGIGVMHRSVQCLTNEDQPSHLCPTDTKPEERKACRNVYNCELPQNCKEVKKLNSASVDGEYF 1751

  Fly  1513 LEVRSRMVHIYCHGMNSRTPQEYVNV--DPQENYSIYYEYRTKQTNSCPPESRGHEYYNDQN--- 1572
            |.||.:.:.::|.||||..|:|||.:  ...||:|..|.:|......||        ||...   
Mouse  1752 LAVRGKPLKVFCAGMNSDYPKEYVTLAHGDSENFSEVYGHRLHNPTECP--------YNGSRRDD 1808

  Fly  1573 ---------SGRTHFRKLRLNITDLRIMDNDFKFA-DSRGLAQKLGSAGDCYNRIGQCPQGDFSI 1627
                     :|.:.|:|:||::|.::|:..|.:|| .|.|......:|||||: ..:||||.|||
Mouse  1809 CHCRKDYTAAGFSSFQKIRLDLTSMQIITTDLEFARTSEGHPVPFATAGDCYS-AAKCPQGRFSI 1872

  Fly  1628 NMKDTDFSIRPGTVWRMHGQYSVMKRISEFDTTTQMRRGFCGGYCGGCYIAPDSGLYLDV 1687
            |:..|..|:.....|...|.|:|.......|.|..:  |.||||||.|  .|.||..|:|
Mouse  1873 NLYGTGLSLTESARWTSQGNYAVSDIKKSPDGTRVV--GKCGGYCGKC--TPSSGTGLEV 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 32/112 (29%)
ZnMc_ADAMTS_like 455..655 CDD:239801 93/228 (41%)
Reprolysin 457..655 CDD:279729 93/210 (44%)
Salp15 <696..745 CDD:288931 21/48 (44%)
TSP1 754..806 CDD:214559 30/51 (59%)
ADAM_spacer1 937..1042 CDD:283607 34/115 (30%)
TSP1 1172..1229 CDD:214559 23/153 (15%)
GON 1495..1687 CDD:285848 71/206 (34%)
Adamts9NP_780523.3 Pep_M12B_propep 49..207 CDD:334593 48/189 (25%)
ZnMc_ADAMTS_like 293..496 CDD:239801 94/213 (44%)
TSP1 591..642 CDD:214559 30/50 (60%)
ADAM_spacer1 753..871 CDD:310520 37/141 (26%)
TSP1 1001..1054 CDD:214559 11/52 (21%)
TSP1 1055..1108 CDD:214559 9/52 (17%)
TSP1 1114..1166 CDD:214559 6/51 (12%)
TSP1 1186..1239 CDD:214559 17/53 (32%)
TSP1 1239..1296 CDD:214559 10/56 (18%)
TSP1 1328..1380 CDD:214559 11/51 (22%)
TSP1 1382..1436 CDD:214559 3/53 (6%)
TSP1 1441..1483 CDD:214559 10/41 (24%)
TSP1 1500..1551 CDD:214559 11/50 (22%)
TSP1 1560..1609 CDD:214559 6/48 (13%)
TSP1 1611..>1636 CDD:214559 3/24 (13%)
GON 1734..1930 CDD:337156 72/208 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5691
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 612 1.000 Inparanoid score I910
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48392
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 1 1.000 - - FOG0004456
OrthoInspector 1 1.000 - - otm44060
orthoMCL 1 0.900 - - OOG6_100241
Panther 1 1.100 - - O PTHR13723
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2551
SonicParanoid 1 1.000 - - X3160
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1312.910

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