DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and adamtsl2

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_021332354.1	Gene:	adamtsl2 / 100537087	ZFINID:	ZDB-GENE-070705-558	Length:	1012	Species:	Danio rerio

Alignment Length:	940	Identity:	244/940 - (25%)
Similarity:	344/940 - (36%)	Gaps:	252/940 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   729 SSGHWCQRGK---CVSNKHGYGRQV-NGGWGPWTPFTPCSLTCGGGVQESRREC-NQPVPENGGK 788
            |.|:...||:   ..||....|.:| ...||.||.:|.|:.||||||....|.| .|......||
Zfish    99 SLGNLSSRGQEEGVASNSLEDGLEVITYWWGEWTKWTACTRTCGGGVMSQERHCLKQRKKTTTGK 163

  Fly   789 ---YCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYEKD------- 843
               .|||:.|||..||..:||......||:||::.|.:..|  |.|  ..|.|.|..|
Zfish   164 DNMTCTGNAKKYHLCNAKECPSTGRSFREEQCWSFNSQVYN--GKN--YHWKPLYPDDYVHISSN 224

  Fly   844 ACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSF-DKCVNGICRPAGCDNELNSIAKLDKCGVCEGR 907
            .|.|.|.........|:.:  .|||||...:: ..||:|.|.|.|||..|.|...|||||||:|.
Zfish   225 PCDLHCTTSDGQRQLMVPA--RDGTSCKYSNYRGVCVDGKCEPIGCDGVLFSPNTLDKCGVCQGD 287

  Fly   908 NDTCHEVTGNL-LVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNE 971
            ..:|..||||. ..::.||..          ::|:||:|:.:|.:.:| ....:.:.:||...|.
Zfish   288 GSSCSRVTGNFRRGASSLGYT----------FITQIPEGSWDIQVIER-KKSADILAVTDQAGNF 341

  Fly   972 LLNGKFLKTYPLKFVYAGVTMQY--------TGSSSVV------EQVNT------------TYSW 1010
            ..||.:....|..|..||...:|        ||...:|      :.:|.            ||.:
Zfish   342 FFNGAYKMDTPQNFHAAGTIFKYRRPTDVYETGIEYIVAKGPIDQPINVLVWNQNGQNPYITYEY 406

  Fly  1011 KLSRDLIVQI---------------ISLDV-------------------------SPSKRQDTVL 1035
            .:.||.:..:               :|::|                         .....|:|..
Zfish   407 TVMRDSMASVSQPPIYTGPQGGSSLVSVEVVSVLQHNQSMYDKNQEQTTGPRAVEGQKPAQETNE 471

  Fly  1036 LSYSYTIDKPPDYEAEVEIYRWEMQAPS------------------NCDSLC-------EGRSHR 1075
            :..:..||...|...:|:........||                  |.::|.       ...|..
Zfish   472 VYETANIDCEQDANTQVQYTEGNCSWPSAVGAPGTATVSRPAEDMVNSENLIWRVLLGERLGSDG 536

  Fly  1076 LPACISTTQ--------GVKVAPQFCDKSAMPK-----------IDDRACNTDCRL---NLT--- 1115
            :.|.|||.|        ..:..|...|.|::.:           :.:|..:||..|   |||
Zfish   537 VLANISTNQLLTHRDGLSSEAEPMELDYSSLEQAGLNGSLLEFTLGNRRNDTDLLLPNRNLTAIL 601

  Fly  1116 ----------------------------VTSISECSAACGELGTREKTYACVQTFTNMQRSNIVD 1152
                                        :::...||..| .:|..:....||: :..::    ||
Zfish   602 RNRGNRTRNNHRLLQKNKPSAADMYRWKLSTQEPCSMTC-SIGVSKSLAMCVR-YDGIE----VD 660

  Fly  1153 MSYC-KLKFDVAYHEEC--REGC---WVLSEWSTCSKSCGTGSQQREAHCYLH-----NSRVSDD 1206
            ..|| .|......|:.|  || |   |..|.||.||::||.|.|.|...|:..     :|.|..|
Zfish   661 DVYCDALTRPEPVHDFCIGRE-CQPRWEASSWSECSRTCGEGFQFRLVRCWKMLAPGLDSSVYSD 724

  Fly  1207 LCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCEK----TRSVSCSHPY 1267
            ||   |:..|..   .....:|.:.|..|      .|.:.||.||...|.:    ||.|.||...
Zfish   725 LC---TEAQLER---PPERRACKSPTCGP------QWEVAEWSECPAKCGRKSLVTREVRCSDEA 777

  Fly  1268 GIGCGSRKPKDVRKC----CHIKYT-SDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYV 1327
            .......:|...:.|    |..::| |:|..||..||.|...:...|.         |.:.|| |
Zfish   778 HACDEETRPPSTKNCTGPPCERQWTASEWGPCSGICGHGKTVRHVYCK---------TAEGRV-V 832

  Fly  1328 DESYCISRKVHRPKLRTTTKSCRIN-C--KWNASDWRRCPADCSEEYQTRDVRCESFQGDGV--- 1386
            .||.|...  ::|   .....|..| |  .|.|.||.||...|....:.|.|.|.|.....|
Zfish   833 PESQCSPE--NKP---LAIHPCGDNECAPHWLAQDWERCNTTCGRGVKRRTVLCVSITSGKVQIN 892

  Fly  1387 EDKHCDAKKRPSKRRIC--NNCVRRQSRVISQC--NC-EGVEKRRDFCFNSHKGRIAC-PTRARV 1445
            ||:.|||.|||:....|  ..|.:..:...|:|  .| .||..|...|:...:....| |....|
Zfish   893 EDEECDASKRPADEDTCFERPCFKWYTTPWSECTKTCGVGVRMRDVKCYQGRELVRGCDPLTKPV 957

  Fly  1446 ERHSC------TPPP--HCRRRSAIGSSIS 1467
            .:.:|      |.||  :|:.|.....|::
Zfish   958 NKQTCALQPCPTEPPDENCQDRPTTNCSLA 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931	6/18 (33%)
		TSP1	754..806	CDD:214559	25/55 (45%)
		ADAM_spacer1	937..1042	CDD:283607	28/170 (16%)
		TSP1	1172..1229	CDD:214559	20/64 (31%)
		GON	1495..1687	CDD:285848
adamtsl2	XP_021332354.1	TSP1	128..184	CDD:214559	25/55 (45%)
		ADAM_spacer1	294..409	CDD:310520	28/125 (22%)
		TSP1	686..745	CDD:214559	20/64 (31%)
		TSP1	919..968	CDD:214559	11/48 (23%)
		PLAC	976..1007	CDD:312271	3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900