DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and adamtsl3

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_003198947.4	Gene:	adamtsl3 / 100534944	ZFINID:	ZDB-GENE-121030-8	Length:	1760	Species:	Danio rerio

Alignment Length:	1057	Identity:	255/1057 - (24%)
Similarity:	379/1057 - (35%)	Gaps:	321/1057 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   753 GWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQC 817
            ||..|..::.||.|||||...|.|.|     .|||. |.|...:||:|:...||..|.|.|.|||
Zfish    77 GWDAWGTWSDCSRTCGGGASYSLRRC-----LNGGN-CEGRNIRYRTCSNTDCPLESGDFRAQQC 135

  Fly   818 YAMNGRNMNIPGVNPDTKWVP-KYEK-DACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVN 880
            .|.|    :|.......:|:| .|:. ..|.|.|:...|.....|...|.|||.|..||.|.|::
Zfish   136 SAHN----DIKYQGQTYEWIPVTYDPVSPCALRCQARGKGQVVELAPKVLDGTRCKADSLDMCIS 196

  Fly   881 GICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLL--VSNLLGLNDGNEPNKTLYYVTRIP 943
            |||:..|||.:|.|.||.|.||||.|...||..:.|..|  ||       ..||.||   |..:|
Zfish   197 GICQEVGCDRQLGSNAKEDNCGVCAGDGSTCRLIRGQALPHVS-------PEEPIKT---VIEVP 251

  Fly   944 KGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVE------ 1002
            .|:..:.||.:| ||  .||:.       .:|:..:...:.|..:|   .::..::.||
Zfish   252 MGSRGLRITAKG-PD--MIVIE-------AHGQNSRREEVHFSSSG---SHSLGNNTVEFQRGAE 303

  Fly  1003 -QVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCD 1066
             |....|. .|:.|..|:     |..:..:|||:....|...:          |:|.......|.
Zfish   304 RQTLRCYG-PLTADFTVK-----VKYAGPKDTVIQFMFYQPIR----------YQWRETDFFPCS 352

  Fly  1067 SLCEGRSHRLPA--CISTTQGVKVAPQFC-----DKSAMPKIDDRACNTD-CRLNLTVTSI---- 1119
            ..| |..::|.:  |:.......||...|     :....||:  :.||.: |..:.....:
Zfish   353 VTC-GGGYQLNSADCVDIRYNRSVAEHLCHSFPENTKPTPKL--KECNMEPCPESDGFKEVMPYD 414

  Fly  1120 -------------SECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREG 1171
                         :.||.:||. |::|::..||:...:.|...:.|.........::     ::.
Zfish   415 HFQPLPRWEQNPWTSCSVSCGG-GSQERSIVCVEEDVHGQIVQVEDWKCTHSPRPIS-----KQN 473

  Fly  1172 C-------WVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHL--NTLIGI-CN-- 1224
            |       |:..|||.|:.:||.|.:.|...|..:|.:.:.. |||..|||:  :.|:.| |:
Zfish   474 CNTFDCPQWMAMEWSQCTVTCGPGLRYRVVLCVDYNGQHAGG-CNPHLKPHIKEDCLVPIACHKP 537

  Fly  1225 TESCPTYTKSP------------NALAVSNWVIGEWGECNEWC---------------------- 1255
            .|:.|...|.|            .||....:|...|..|:..|
Zfish   538 RENQPVEAKLPWLKQAQELEETKVALEDPTFVPEPWSSCSVSCGLGIQRRQVKCKVLLSFTQAEV 602

  Fly  1256 ---------EKTRS--------------------------------------VSCSHPYGIG--- 1270
                     ||..|                                      .:||....:|
Zfish   603 ELPDEECHEEKPSSQRSCDSGPCLAAPDSSRWPLRTPEGPNQHGYAWEYIGFTACSASCAVGKQM 667

  Fly  1271 ------------------C-GSRKPKDVRKCCHIK------YTSDWTDCSVQCGEGVKRKKQSCT 1310
                              | ||:.|..:.:.|:.:      ..|.|..|||.||.|::.:..||.
Zfish   668 AVVRCVNTLKKEIVDDLLCNGSKAPVSLLRICNPQPCPSRWEVSVWNLCSVSCGVGLQTRSVSCV 732

  Fly  1311 RVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSC-RINC--KWNASDWRRCPADCSEEYQ 1372
            |    .|.|.|...  :....|:.:   ||   ...::| ::.|  .|.|.:|::|...|....|
Zfish   733 R----SVAGNRTES--LSSKDCVEK---RP---NELQACNQVACPPSWEAEEWQQCSHSCGRGSQ 785

  Fly  1373 TRDVRCESFQGDG----VEDKHCDAKKRPSKRRICNN--CV--RRQSRVISQCN--C-EGVEKRR 1426
            .|.|.|:.....|    :.|:.|...| |...|||.|  |:  |.:....|:|:  | :||::|.
Zfish   786 WRKVYCKQRLATGSYRRLRDEDCSGPK-PDVHRICTNADCLLPRLEGGEWSKCSVTCGKGVQRRE 849

  Fly  1427 DFCFNSHKGRIACPTRARVERHSCT----PP-------------PHCRRR--SAIGSS---ISSR 1469
            ..|    :.:.|......::|.||:    ||             .|.::|  ..||..   |.:|
Zfish   850 PVC----RRQTASGQLVTLDRTSCSDLPLPPLIRSCRMSPCNKHKHSKKRCPQVIGLKRIYIQNR 910

  Fly  1470 PRGTGVSSSRSLNSIGGSRNRGTPRSCADL--------KEMHGYNKDGN---------------- 1510
            |      ..|...:||| |....|::...:        |....:.|||:
Zfish   911 P------EKRLSFTIGG-RAYLLPKTTVIIKCPVRHFPKAQIRWEKDGDELTSSKRLSITKSGAL 968

  Fly  1511 --YQLEVRSRMVHIYCHGMNSRTPQEYVNVDPQENYSIYYEYRTKQTNSCPPESRG--HEYYNDQ 1571
              |.||...  :.:|....|..:....:.:       |.|..|.....|...|.||  |.|.|.:
Zfish   969 RIYNLEAED--IGVYRCWANQDSDTFILKL-------IGYNNRLLDHPSLGKERRGNFHPYLNKE 1024

  Fly  1572 --------NSGRTHFRK 1580
                    |.|.|:..|
Zfish  1025 GGFVSSKCNEGFTNGNK 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559	20/51 (39%)
		ADAM_spacer1	937..1042	CDD:283607	25/111 (23%)
		TSP1	1172..1229	CDD:214559	22/68 (32%)
		GON	1495..1687	CDD:285848	23/122 (19%)
adamtsl3	XP_003198947.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810