DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and adamts8

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_002940685.2	Gene:	adamts8 / 100497759	XenbaseID:	XB-GENE-994782	Length:	956	Species:	Xenopus tropicalis

Alignment Length:	1226	Identity:	317/1226 - (25%)
Similarity:	474/1226 - (38%)	Gaps:	434/1226 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 GRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLG--------------CFYS 352
            ||.:.|.|..|.:|:                  ||..:.    :|:|              ||||
Frog    55 GRDIELHLVPDDAFL------------------GPRMQI----KHVGRAGGTQTSMDGLRTCFYS 97

  Fly   353 GYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEVL--HRVFRKSQRN--ARHAVSK 413
            ..   :|  :.:||||.|:.|.......:.:|||.......:.|  |.||:...:|  :.|
Frog    98 SM---EP--LAAVSLCKGVQGAFMHGSDSYVIQPRKELRGQKKLGQHLVFKAQNKNIPSWH---- 153

  Fly   414 FELGLDDFMSKL-EQVQEEEQKSKSRKLNRKKRH------------------------------- 446
                  |..|:| |.:..:|.:.:..||...:|:
Frog   154 ------DKSSELTEDINNQEWEKQDLKLKDTQRNNPIFGQKESVLLQDAKEIVSGHSSNLWTIHE 212

  Fly   447 --YADVDNQVY-------------TLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIG 496
              .:||..:..             .:|:|:..||:|.||:|:||:.::|.|||:.:.|:...|:.
Frog   213 ISKSDVKGETVHPFRNRRFVSEDRFIEILLVADNTMVQFYGDDLELHLLTLMSVAARIYKHPSLR 277

  Fly   497 NSIRILLVRLISLPNIN---DQTHSSNEMLKHFC---QFINQSGYER----DTAMLITREPICGS 551
            ||:.:::|.::.:.::.   |.:.:....|:.||   |..|.|....    |||.|:||:.|||.
Frog   278 NSVTLVVVTVLLVEDVESGPDVSDNGGLTLRSFCNWQQNFNPSSDRNPEHYDTAFLLTRQDICGH 342

  Fly   552 VPGKICHMLGLAELGTVC-SSSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNN 615
               :.|..||:|::|||| :|.|||:::|.||..|:|:||||||:|::.||:...|..|......
Frog   343 ---ESCDTLGVADIGTVCDTSKSCSVIEDNGLQAAYTLAHELGHVLSIPHDNSKNCERYFGELGR 404

  Fly   616 NKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL--ETSVGAHIPYGTERLPG--EIYS 676
            :   |:|:|::.:: ....||:||...::||.:.....||  ..|....:|.|   |||  .:|.
Frog   405 H---HLMASLLQLN-KTVPWSECSAMHLTEFFDSGHGDCLLDAPSKSIELPNG---LPGTSALYD 462

  Fly   677 LDAQCQLSFGNDFGYCPTDEE---CKRLWCNRTSGNSNEQCASSN--LPWADGTPCGSSGHWCQR 736
            ||:||:..||.:|.:||...|   |.:|||.....|   :|.:.|  ||||||||||.: |.|..
Frog   463 LDSQCRQVFGKEFSHCPNTLEKDVCSQLWCRIQEKN---ECHTKNGSLPWADGTPCGDN-HMCSD 523

  Fly   737 GKCVSNKHGYGRQ--VNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRS 799
            |.||........:  |:|.||.|.|:..||.||||||:.|.|:||.|||:||||||.|.|..|.|
Frog   524 GVCVKEDIVVRPKVPVDGSWGSWGPWGECSRTCGGGVRFSYRDCNDPVPQNGGKYCKGQRAMYES 588

  Fly   800 CNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPD-----TKWVPKYE----KDACKLFCRMDMKV 855
            ||..:||...:..||:||...|..|..      |     .:|:|||.    :|.|||.|:...:.
Frog   589 CNIQECPVHELSFREEQCMKYNSYNYT------DEEGTLLQWIPKYSGVSYRDRCKLVCQARDRN 647

  Fly   856 TYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLV 920
            .:.:.:|.|.|||.|..||...||.|.|..||||:.|.|..|:||||||.|...:|.::|.:.
Frog   648 EFKVFQSKVVDGTLCEPDSLKVCVQGQCISAGCDHILGSSKKMDKCGVCGGDGSSCRKITDSF-- 710

  Fly   921 SNLLGLNDGNEPNKTLYYVT---RIPKGASNIIITQRGYP----DQNFIVLTDDRDNELLNGKFL 978
                        ||:.|..|   .||.||:||.|.:|.:.    |.|::.:.....:.||||.|.
Frog   711 ------------NKSKYGYTDIVSIPAGATNIDIKKRSHRGIIYDGNYLAIKKADGSYLLNGDFA 763

  Fly   979 KTYPLKFVY-AGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISL--DVSPSKRQDTVLLSYSY 1040
            .:|..:.:: .|:.::|:||.:.:|::.:.|  .|...|.:|::|:  :..|.|      :.|::
Frog   764 VSYMEQDLHLRGIVLKYSGSLTTLERIRSFY--PLPESLTIQLLSVLAETLPPK------VKYTF 820

  Fly  1041 TIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRA 1105
            .|.|...|                                     .|..|:....|..|.:..:
Frog   821 FIPKNVSY-------------------------------------AKTKPKLSHHSLRPLLTSQ- 847

  Fly  1106 CNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECRE 1170

Frog   848 ----------------------------------------------------------------- 847

  Fly  1171 GCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSP 1235
              |...:|..||||||.|.|:|...|.......||                     .||.
Frog   848 --WTFRDWFPCSKSCGFGWQRRAVECQDVEGGPSD---------------------QCPQ----- 884

  Fly  1236 NALAVSNWVIGEWGECNEWCEKTRSVSCSHPYGIGCGSRKPKDVRKC----CHIKYTSDWTDCSV 1296
                                                 ..:|.|:|.|    |.|.....|:.||.
Frog   885 -------------------------------------ELRPIDIRPCGDLPCPIWRVGGWSPCSQ 912

  Fly  1297 QCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINCKWNASDWR 1361
            .|||||                  |.:||:
Frog   913 SCGEGV------------------RSQRVF----------------------------------- 924

  Fly  1362 RCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVISQC 1417
                            |..:.|...|::.||..|||:|.  .|:|      ::.:|
Frog   925 ----------------CVDYTGRETEEEKCDPGKRPAKP--VNSC------ILEEC 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	24/105 (23%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	72/223 (32%)
		Reprolysin	457..655	CDD:279729	72/208 (35%)
		Salp15	<696..745	CDD:288931	23/53 (43%)
		TSP1	754..806	CDD:214559	31/51 (61%)
		ADAM_spacer1	937..1042	CDD:283607	31/114 (27%)
		TSP1	1172..1229	CDD:214559	14/56 (25%)
		GON	1495..1687	CDD:285848
adamts8	XP_002940685.2	Pep_M12B_propep	33..142	CDD:366707	26/113 (23%)
		ZnMc_ADAMTS_like	236..441	CDD:239801	73/211 (35%)
		ADAM_CR_2	455..527	CDD:375321	33/75 (44%)
		TSP1	543..595	CDD:214559	31/51 (61%)
		ADAM_spacer1	704..823	CDD:368694	34/140 (24%)
		TSP1	846..900	CDD:214559	20/184 (11%)
		TSP1	905..942	CDD:214559	16/105 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7711
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110