Protein Alignment AdamTS-A and adamts8

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: XP_002940685.2
• Gene: adamts8 / 100497759
• XenbaseID: XB-GENE-994782
• Length: 956
• Species: Xenopus tropicalis
• Alignment Length: 1226
• Identity: 317/1226 - (25%)
• Similarity: 474/1226 - (38%)
• Gaps: 434/1226 - (35%)

  Fly   302 GRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLG--------------CFYS 352
            ||.:.|.|..|.:|:                  ||..:.    :|:|              ||||
 Frog    55 GRDIELHLVPDDAFL------------------GPRMQI----KHVGRAGGTQTSMDGLRTCFYS 97

  Fly   353 GYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEVL--HRVFRKSQRN--ARHAVSK 413
            ..   :|  :.:||||.|:.|.......:.:|||.......:.|  |.||:...:|  :.|
 Frog    98 SM---EP--LAAVSLCKGVQGAFMHGSDSYVIQPRKELRGQKKLGQHLVFKAQNKNIPSWH---- 153

  Fly   414 FELGLDDFMSKL-EQVQEEEQKSKSRKLNRKKRH------------------------------- 446
                  |..|:| |.:..:|.:.:..||...:|:
 Frog   154 ------DKSSELTEDINNQEWEKQDLKLKDTQRNNPIFGQKESVLLQDAKEIVSGHSSNLWTIHE 212

  Fly   447 --YADVDNQVY-------------TLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIG 496
              .:||..:..             .:|:|:..||:|.||:|:||:.::|.|||:.:.|:...|:.
 Frog   213 ISKSDVKGETVHPFRNRRFVSEDRFIEILLVADNTMVQFYGDDLELHLLTLMSVAARIYKHPSLR 277

  Fly   497 NSIRILLVRLISLPNIN---DQTHSSNEMLKHFC---QFINQSGYER----DTAMLITREPICGS 551
            ||:.:::|.::.:.::.   |.:.:....|:.||   |..|.|....    |||.|:||:.|||.
 Frog   278 NSVTLVVVTVLLVEDVESGPDVSDNGGLTLRSFCNWQQNFNPSSDRNPEHYDTAFLLTRQDICGH 342

  Fly   552 VPGKICHMLGLAELGTVC-SSSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNN 615
               :.|..||:|::|||| :|.|||:::|.||..|:|:||||||:|::.||:...|..|......
 Frog   343 ---ESCDTLGVADIGTVCDTSKSCSVIEDNGLQAAYTLAHELGHVLSIPHDNSKNCERYFGELGR 404

  Fly   616 NKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL--ETSVGAHIPYGTERLPG--EIYS 676
            :   |:|:|::.:: ....||:||...::||.:.....||  ..|....:|.|   |||  .:|.
 Frog   405 H---HLMASLLQLN-KTVPWSECSAMHLTEFFDSGHGDCLLDAPSKSIELPNG---LPGTSALYD 462

  Fly   677 LDAQCQLSFGNDFGYCPTDEE---CKRLWCNRTSGNSNEQCASSN--LPWADGTPCGSSGHWCQR 736
            ||:||:..||.:|.:||...|   |.:|||.....|   :|.:.|  ||||||||||.: |.|..
 Frog   463 LDSQCRQVFGKEFSHCPNTLEKDVCSQLWCRIQEKN---ECHTKNGSLPWADGTPCGDN-HMCSD 523

  Fly   737 GKCVSNKHGYGRQ--VNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRS 799
            |.||........:  |:|.||.|.|:..||.||||||:.|.|:||.|||:||||||.|.|..|.|
 Frog   524 GVCVKEDIVVRPKVPVDGSWGSWGPWGECSRTCGGGVRFSYRDCNDPVPQNGGKYCKGQRAMYES 588

  Fly   800 CNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPD-----TKWVPKYE----KDACKLFCRMDMKV 855
            ||..:||...:..||:||...|..|..      |     .:|:|||.    :|.|||.|:...:.
 Frog   589 CNIQECPVHELSFREEQCMKYNSYNYT------DEEGTLLQWIPKYSGVSYRDRCKLVCQARDRN 647

  Fly   856 TYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLV 920
            .:.:.:|.|.|||.|..||...||.|.|..||||:.|.|..|:||||||.|...:|.::|.:.
 Frog   648 EFKVFQSKVVDGTLCEPDSLKVCVQGQCISAGCDHILGSSKKMDKCGVCGGDGSSCRKITDSF-- 710

  Fly   921 SNLLGLNDGNEPNKTLYYVT---RIPKGASNIIITQRGYP----DQNFIVLTDDRDNELLNGKFL 978
                        ||:.|..|   .||.||:||.|.:|.:.    |.|::.:.....:.||||.|.
 Frog   711 ------------NKSKYGYTDIVSIPAGATNIDIKKRSHRGIIYDGNYLAIKKADGSYLLNGDFA 763

  Fly   979 KTYPLKFVY-AGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISL--DVSPSKRQDTVLLSYSY 1040
            .:|..:.:: .|:.::|:||.:.:|::.:.|  .|...|.:|::|:  :..|.|      :.|::
 Frog   764 VSYMEQDLHLRGIVLKYSGSLTTLERIRSFY--PLPESLTIQLLSVLAETLPPK------VKYTF 820

  Fly  1041 TIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRA 1105
            .|.|...|                                     .|..|:....|..|.:..:
 Frog   821 FIPKNVSY-------------------------------------AKTKPKLSHHSLRPLLTSQ- 847

  Fly  1106 CNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECRE 1170
                                                                             
 Frog   848 ----------------------------------------------------------------- 847

  Fly  1171 GCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSP 1235
              |...:|..||||||.|.|:|...|.......||                     .||.
 Frog   848 --WTFRDWFPCSKSCGFGWQRRAVECQDVEGGPSD---------------------QCPQ----- 884

  Fly  1236 NALAVSNWVIGEWGECNEWCEKTRSVSCSHPYGIGCGSRKPKDVRKC----CHIKYTSDWTDCSV 1296
                                                 ..:|.|:|.|    |.|.....|:.||.
 Frog   885 -------------------------------------ELRPIDIRPCGDLPCPIWRVGGWSPCSQ 912

  Fly  1297 QCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINCKWNASDWR 1361
            .|||||                  |.:||:
 Frog   913 SCGEGV------------------RSQRVF----------------------------------- 924

  Fly  1362 RCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVISQC 1417
                            |..:.|...|::.||..|||:|.  .|:|      ::.:|
 Frog   925 ----------------CVDYTGRETEEEKCDPGKRPAKP--VNSC------ILEEC 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	24/105 (23%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	72/223 (32%)
		ADAMTS_CR_2	671..740	CDD:465496	33/75 (44%)
		TSP1	754..806	CDD:214559	31/51 (61%)
		ADAMTS_CR_3	815..911	CDD:437068	40/104 (38%)
		TSP1	1172..1229	CDD:214559	14/56 (25%)
		TSP1_ADAMTS	1243..1282	CDD:465950	3/38 (8%)
		TSP1_ADAMTS	1355..1405	CDD:465950	9/49 (18%)
		GON	1493..1687	CDD:462559
adamts8	XP_002940685.2	Pep_M12B_propep	<49..142	CDD:460254	26/113 (23%)
		ZnMc_ADAMTS_like	236..441	CDD:239801	73/211 (35%)
		ADAMTS_CR_2	455..527	CDD:465496	33/75 (44%)
		TSP1	543..595	CDD:214559	31/51 (61%)
		ADAMTS_CR_3	598..703	CDD:437068	42/110 (38%)
		ADAMTS_spacer1	705..823	CDD:461796	34/139 (24%)
		TSP1_ADAMTS	848..899	CDD:465950	20/113 (18%)
		TSP1_ADAMTS	902..956	CDD:465950	22/130 (17%)