Protein Alignment AdamTS-A and adamts2

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: XP_012815203.2
• Gene: adamts2 / 100492431
• XenbaseID: XB-GENE-492342
• Length: 1170
• Species: Xenopus tropicalis
• Alignment Length: 1262
• Identity: 334/1262 - (26%)
• Similarity: 518/1262 - (41%)
• Gaps: 291/1262 - (23%)

  Fly   253 ADLIYESKRNSDINSFLKESASAFAMT-------GTY--------------RNMSN-------EI 289
            |..:|.||   |.:|.||:......:|       |.|              |:.||       .|
 Frog    20 AHTLYISK---DRDSLLKKLEEYSLVTPVSTDSKGKYVSHSVTKRETHRYRRDASNLEKTSAERI 81

  Fly   290 WDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAE-------AEQRHL 347
            :     ||:.||||:.||.||.::..|                .||...|.|       .|..:.
 Frog    82 Y-----YNVTVFGREFHLKLRVNSKLV----------------APGATIEWEEDANVTVIEPLNT 125

  Fly   348 GCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDE---VLHRVFRKS------ 403
            .|.|.|.:.|.|::.|::|.|.|:.|.|:|......|:|:.:....|   .:|.|:|:|
 Frog   126 NCLYVGDITDLPNASVAISNCDGLAGIIRTEEEEFFIEPLEKDKEGEDEGRVHIVYRRSAVLKSF 190

  Fly   404 ---------QRNARHAVSKFELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEV 459
                     ....:|:.:..|..:|:.         :||.:.:||  |.:||.:|.|   :.:|:
 Frog   191 QGNNTDIQLNETTQHSPNLLENIIDNV---------QEQVNSTRK--RTRRHASDDD---FNIEI 241

  Fly   460 LIAVDNSMKQFHGED-LQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNIND----QTHSS 519
            |:.||:|:.||||:: :|.|:|.|::||:.|:.|.|:|..|.::|||:|.|.:...    :..:.
 Frog   242 LLGVDDSVVQFHGKEYVQKYLLTLLNIVNEIYHDESLGAHINVVLVRIIMLSHSKSSSLIEVGNP 306

  Fly   520 NEMLKHFCQ--FINQ---SGYE--RDTAMLITRE-----------PICGSVPGKICHMLGLAELG 566
            ::.|::.|:  ::.|   :|:.  .|.|:.:||:           |:.|     :||.:
 Frog   307 SQSLENVCRWAYLQQKPETGHAEYHDHAIFLTRQEFGPSGMQGYAPVTG-----MCHPV------ 360

  Fly   567 TVCSSSSCSIVQDTGLPTAFTMAHELGHILNMNHD-DDDKCMPYVTRQNNNKVLHIMSSVMGIHM 630
                 .||::..:.|..:||.:|||.||:|.|.|| ..::|...|      ::..||:.::....
 Frog   361 -----RSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEV------RMGSIMAPLVQAAF 414

  Fly   631 HPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP-- 693
            |.:.||:||:..:|.:|...|  ||......|......:|||..||::.||:..||..:..|.
 Frog   415 HRFHWSRCSQQELSRYLNSYD--CLRDDPFEHNWPSLPQLPGIHYSMNEQCRFDFGLGYMMCTAF 477

  Fly   694 -TDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPW 757
             |.:.||:|||:.|  ::...|.:...|..|||.| |.|..|.:|.|:.......|| :|.||.|
 Frog   478 RTFDPCKQLWCSHT--DNPYFCKTKKGPPLDGTMC-SYGKHCFKGHCIWLTPDILRQ-DGNWGQW 538

  Fly   758 TPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQC----- 817
            :.|..||.:||.||:...|.|:.|.|.|||:.|:|...:.:.|||..|.....|.||:||
 Frog   539 SKFGSCSRSCGTGVRYRTRSCDNPHPANGGRSCSGPSYELQLCNTEDCKTDFDDFREEQCKQWDP 603

  Fly   818 ---YAMNGRNMNIPGVNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKSMVTDGTSCAV-DSFDKC 878
               |..:..|. :|..:||       ||:.|.|:|:.........:|.:..|||.|:. ||::.|
 Frog   604 YFEYQDSKHNW-LPYDHPD-------EKERCHLYCQSKETGDVVYMKRLTHDGTRCSYKDSYNIC 660

  Fly   879 VNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKT-LYYVTRI 942
            |.|.|...|||..:.|..|.||||||.|.|..|..|.|...          ..|.|. ...:..|
 Frog   661 VRGECLKVGCDKVIGSKKKEDKCGVCGGDNSHCKVVKGTFT----------RTPRKQGNVRIFEI 715

  Fly   943 PKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLK-FVYAGVTMQYTGSSSVVEQVNT 1006
            |.||.:::|.:.|....|..:........:||.:.:.....| ||..|:..:|....: .|.|.|
 Frog   716 PVGARHLLIQETGASIHNLAIKNQASGKFILNDENVTLPDSKIFVNMGIEWEYQNDDN-RETVQT 779

  Fly  1007 TYSWKLSRDLIVQIISLDVSPSKRQDTVLLSY-------SYTIDKPPDYEAEVEIYRWEMQAPSN 1064
              ...|...:.:.:|      .:....:.|||       |:.:|.....|..|..|.|.::..|:
 Frog   780 --MGPLHNPITILVI------PRGHSKISLSYKYMIHEDSFNVDNNNVVEDVVVTYEWTLKKWSH 836

  Fly  1065 CDSLCEGRSHRLP--ACISTTQGVKVAPQFCDKSAMPKIDDRACN-TDCRLNLTVTSISE-CSAA 1125
            |...| |..|:..  .|...:....|...|||.....|...|.|| .:|...|.::...| |:..
 Frog   837 CSKPC-GGGHQFTKYGCRRKSDHKMVHKNFCDSIQKLKPIRRVCNLQECSQPLWISGEWEPCTVT 900

  Fly  1126 CGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGC---WVLSEWSTCSKSCGT 1187
            ||:.|.:.:|..|:|.. |..::..|...||......|.....|:.|   |.:..||.||.:||.
 Frog   901 CGKSGYQFRTVKCIQPL-NDNKNRSVHNKYCSDDRPEAKRPCNRQPCPAQWRIGPWSQCSVTCGN 964

  Fly  1188 GSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEW---- 1248
            |:::|:.||   .|.::........||.   .|.||....|......|..   .|::: :|
 Frog   965 GTEERQVHC---GSDINKSANCSEEKPE---TIRICRLSPCSGNASDPYK---KNYIV-QWLSKL 1019

  Fly  1249 --------GECNEWCEKTRSVSCSHPYGIGCGSR---KPKDVRKCCH------------------ 1284
                    ....|.|.:.:|:.|.    :|...|   .|...|.||.
 Frog  1020 DPDYPLHKISSKESCLEDKSMVCR----LGILQRYCSVPGYSRMCCKACNASQLYNDSKMNSSSD 1080

  Fly  1285 ---------------IKYTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCIS 1334
                           :.:|.|:              ||:   |..|::......|  ||..|.|.
 Frog  1081 PALPIPSPPTLYNTTVTFTPDY--------------KQN---VSNPNITDQHNNR--VDVPYKIQ 1126

  Fly  1335 RKVHR-------PKLRTT---TKSCRI 1351
            ...:.       |:.|:|   ||:.||
 Frog  1127 ELQNEVPQLNAIPRRRSTFGRTKNQRI 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	30/105 (29%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	63/223 (28%)
		ADAMTS_CR_2	671..740	CDD:465496	26/71 (37%)
		TSP1	754..806	CDD:214559	22/51 (43%)
		ADAMTS_CR_3	815..911	CDD:437068	36/104 (35%)
		TSP1	1172..1229	CDD:214559	18/59 (31%)
		TSP1_ADAMTS	1243..1282	CDD:465950	9/53 (17%)
		TSP1_ADAMTS	1355..1405	CDD:465950
		GON	1493..1687	CDD:462559
adamts2	XP_012815203.2	Pep_M12B_propep	41..181	CDD:460254	39/160 (24%)
		ZnMc_ADAMTS_like	238..438	CDD:239801	64/223 (29%)
		ADAMTS_CR_2	453..522	CDD:465496	26/71 (37%)
		TSP1	535..586	CDD:214559	22/50 (44%)
		ADAMTS_CR_3	<619..693	CDD:437068	31/80 (39%)
		ADAMTS_spacer1	695..808	CDD:461796	26/131 (20%)
		TSP1_ADAMTS	829..884	CDD:465950	15/55 (27%)
		TSP1_ADAMTS	889..946	CDD:465950	14/57 (25%)
		TSP1_ADAMTS	950..999	CDD:465950	17/54 (31%)