DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and adamts15

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_012822382.1	Gene:	adamts15 / 100489270	XenbaseID:	XB-GENE-6051208	Length:	938	Species:	Xenopus tropicalis

Alignment Length:	986	Identity:	304/986 - (30%)
Similarity:	468/986 - (47%)	Gaps:	179/986 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPH 360
            :.:..|....:|.|..||.|:......|.         ||...:...:.||  |||||.|..|..
Frog    60 FQITAFYEDFYLNLIPDAQFIAPAFSMHF---------PGSIPKQSPDLRH--CFYSGDVNSDRD 113

  Fly   361 SMVSVSLCGGMTGYIKTSFG----ALLIQPVNRTSSDEVL------HRVFRKS------QRNARH 409
            |..::|||||:.|    :||    ..||:|:...:.|::.      |.:.|:.      ...:|.
Frog   114 SFAALSLCGGLRG----AFGYQGEEYLIRPLQNVTRDQLQSSHQGPHLLQRRKGPLKSVDTTSRC 174

  Fly   410 AV-SKFELGLDDFMSKLEQVQEEEQKSKSR-KLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG 472
            .| |....|:.:.::|.:....::|.:.:| |.:.:.|.:|.:...|   |.||..|.:|.:|||
Frog   175 GVGSGLNQGIMEALNKYKGSHNKKQLNGTRLKGSHRSRRFASITRYV---ETLIVADETMLKFHG 236

  Fly   473 EDLQPYILILMSIVSSIFADASIGNSIRILLVRLISL------PNINDQTHSSNEMLKHFCQFIN 531
            :|||.|:|.||:..:.::...||.|.|.|::|:.:.|      |.:   |.::...|:.||
Frog   237 DDLQHYLLTLMATAARLYRHPSIQNPINIVVVKFMVLTDDGKGPKV---TTNAAMTLRSFC---- 294

  Fly   532 QSGYER-------------DTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGL 582
              |:::             |||:|.|:..:||:   ..|..||:|::||:|. ..|||:::|.||
Frog   295 --GWQKKWNKVSDKHPEYWDTAILFTKMDLCGA---STCDTLGMADVGTMCDPKRSCSVIEDDGL 354

  Fly   583 PTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHM---HPWSWSKCSRHFVS 644
            |:|||.||||||:.||.||:...|.....:...|   ::||..: |.:   :|  ||.||...::
Frog   355 PSAFTTAHELGHVFNMPHDNVKVCEEAFGKLREN---YMMSPTL-IQIDRANP--WSACSAAIIT 413

  Fly   645 EFLEKTDKSCL--ETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEECKRLWCNRTS 707
            :||:.....||  |.:....:|   |.|||..|||..||:|:||.....||..:.|.:|||   :
Frog   414 DFLDSGHGECLLDEPAKPISLP---EELPGARYSLSRQCELAFGLGSKPCPYMQYCTKLWC---T 472

  Fly   708 GNSNEQ--CASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGR-QVNGGWGPWTPFTPCSLTCGG 769
            |.:..|  |.:.:.||||||.|| .|.:|..|.|| .:|...| :|:|.||.|:|:..||.||||
Frog   473 GRARGQLVCQTRHFPWADGTSCG-DGKFCLNGACV-ERHNVNRYKVDGAWGKWSPYGQCSRTCGG 535

  Fly   770 GVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDT 834
            |||.::||||.|.|.|||.:|.|.|.|||||:.:.||......||:||.:.||.|.:...:....
Frog   536 GVQLAKRECNNPEPSNGGSFCEGLRVKYRSCSLNPCPETGKSFREEQCESFNGFNHSTNRITQTV 600

  Fly   835 KWVPKYE----KDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSI 895
            .|||||.    :|.|||.||.:....:::|...|.|||.|:.|:...||.|.|..||||.:|.|.
Frog   601 GWVPKYSGVSPRDKCKLICRANGTGYFYVLSPKVVDGTPCSPDATSVCVQGKCIKAGCDGQLGSK 665

  Fly   896 AKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYP--- 957
            .|.|||.||.|.|.:|.:::| |....:.|.|          :|..||.||||:.:.||||.
Frog   666 KKYDKCRVCGGDNKSCKKISG-LFTKPIHGYN----------FVVTIPAGASNLDVRQRGYKGLI 719

  Fly   958 -DQNFIVLTDDRDNELLNGKFLKTYPLKFV-YAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQI 1020
             |.|::.:.:.:...||||.::.....:.: ..|..::|:|:.:.||.:...       ::|.:.
Frog   720 NDDNYLAVKNAQGRYLLNGNYIVAAGERDISVRGSLLKYSGTGTAVETLQAI-------NVIQES 777

  Fly  1021 ISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQG 1085
            ::::|....:.....|.||:.|.:                         |.:..::...||.:..
Frog   778 LTIEVLCVGKMTPPRLRYSFYIPR-------------------------EKKDGKVGQVISNSLA 817

  Fly  1086 VKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNI 1150
            ....|       :|::..::       |....:..:||.:|| .|.:.:|..|...:..:
Frog   818 GLPPP-------LPRLKPQS-------NWIAGNWGDCSVSCG-TGHQIRTIECRDPWEQL----- 862

  Fly  1151 VDMSYCKLKFDVAYHEECREGC--WVLSEWSTCSKSCGTGSQQRE-------------AHCYLHN 1200
              .|.|:.....:....|.:.|  |...|||:||||||.|.::|:             .||:|..
Frog   863 --ASDCQAALRPSERRTCGDPCPVWDAGEWSSCSKSCGRGFKRRQLRCSADGGVTLPREHCHLKR 925

  Fly  1201 SRVSDDLCNPR 1211
            .....|.||.|
Frog   926 KPQELDFCNIR 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	30/101 (30%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	74/222 (33%)
		Reprolysin	457..655	CDD:279729	74/220 (34%)
		Salp15	<696..745	CDD:288931	20/50 (40%)
		TSP1	754..806	CDD:214559	30/51 (59%)
		ADAM_spacer1	937..1042	CDD:283607	27/109 (25%)
		TSP1	1172..1229	CDD:214559	20/55 (36%)
		GON	1495..1687	CDD:285848
adamts15	XP_012822382.1	Pep_M12B_propep	30..158	CDD:366707	32/112 (29%)
		ZnMc_ADAMTS_like	219..425	CDD:239801	76/226 (34%)
		ADAM_CR_2	439..506	CDD:375321	30/70 (43%)
		TSP1	520..572	CDD:214559	30/51 (59%)
		ADAM_spacer1	682..800	CDD:368694	31/135 (23%)
		TSP1	835..883	CDD:214559	10/55 (18%)
		TSP1	884..938	CDD:214559	19/53 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5505
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020