DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and adamts4

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_004919795.1	Gene:	adamts4 / 100487641	XenbaseID:	XB-GENE-996659	Length:	852	Species:	Xenopus tropicalis

Alignment Length:	873	Identity:	284/873 - (32%)
Similarity:	420/873 - (48%)	Gaps:	112/873 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 DLIYESKRNSDINSFLKESASAFAMTGTYRNMSNE-IWDPHPQYNLNVFGRQLHLVLRQDASFVH 317
            ::::..:.||   ||.:|...       :...:|| ..|.|..:....||.:|.|.:.:|.||:
Frog    41 EIVFPERLNS---SFRQEHPQ-------WPGSANEPPSDGHLIFRFRAFGEELILDMERDPSFL- 94

  Fly   318 NHSMTHIRILKEGEEHPGPETEAEAE-QRHLGCFYSGYVEDDPHSMVSVSLCG-GMTGYIKTSFG 380
            :..:|        .::.|...:::|: ....|.:::|.|..||.|:.:|:..| .:.|.::....
Frog    95 SEDLT--------VQYLGRNRQSDADGLSEPGSYFTGAVNSDPESIAAVNYNGASLVGVLQYRGA 151

  Fly   381 ALLIQPVNRTSSDEV----LHRVFRKSQRNARHAVSKFELGLDDFMSKLEQVQEEEQKSKSRKLN 441
            ...|||:.....:.|    .|.:.||....:...:.  .:|...........:.::...|||..:
Frog   152 EFHIQPLEGGGPNSVEGVGAHVIRRKVPDRSNGPMC--NVGTQGEKKGSRDAEPKDNTVKSRAAS 214

  Fly   442 RKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRL 506
            .:.:.:|.|...|   |.|:..|.:|..|||.||:.|:|.:::..:..|...|:.|.:.:::.||
Frog   215 TRSKRFASVPRYV---ETLVVADETMADFHGADLKRYLLTVLAASAKFFRHPSLKNPVNVVVTRL 276

  Fly   507 ISLPNIN--------DQTHSSNEMLKHFCQFINQSGYER---------DTAMLITREPICGSVPG 554
            :.:...:        ..|.::.|||::||::  |.|..:         |||:|.||:.:||.
Frog   277 VVIGKADKAQKYGGLKMTTNAAEMLRNFCEW--QKGLNKQNDSDSEHFDTAILFTRQNLCGV--- 336

  Fly   555 KICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKV 618
            ..|..||:|::||||. |.|||||:|.||.:|||.||||||:.||.||:...|:......:|.:
Frog   337 STCDTLGMADVGTVCDPSRSCSIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCVELNRPSSNTR- 400

  Fly   619 LHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL----ETSVGAHIPYGTERLPGEIYSLDA 679
             |:|:.||........||.||..|:::||:..:..||    .|.:...:|:     ||..|..|.
Frog   401 -HMMAPVMSFVDPEELWSPCSAKFITDFLDNGNGHCLLDKPRTPLRLPVPF-----PGNDYDADR 459

  Fly   680 QCQLSFGNDFGYCPT-DEECKRLWC-NRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVS- 741
            ||||:||.|..:||. ...|..||| .:..|:.  .|.:.:.||||||.|| .|..|..|:|:|
Frog   460 QCQLTFGPDSRHCPNLHTPCSSLWCTGKIDGHF--MCQTKHFPWADGTSCG-VGKTCMNGRCISK 521

  Fly   742 -NKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQC 805
             ....:...||||||||.|:..||.|||||||.|.||||:|||.||||||.|.|.:||||||..|
Frog   522 VEMKAFNTPVNGGWGPWGPYGQCSRTCGGGVQFSHRECNKPVPRNGGKYCEGKRTQYRSCNTQMC 586

  Fly   806 PPG-SMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY----EKDACKLFCRMDMKVTYFMLKSMVT 865
            ..| ::..|||||.|.|.|............|||:|    |||.|||.|:......|::|:..|.
Frog   587 ALGNALTYREQQCAAYNHRTDMFKTFPSPMDWVPRYNGIAEKDRCKLTCQSRPLGYYYVLEPRVA 651

  Fly   866 DGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGN 930
            |||.|:.||...||.|.|..||||..:.|..|.|||.||.|...||.:..|:.           .
Frog   652 DGTPCSPDSTSVCVQGRCVHAGCDRIIGSKKKFDKCMVCGGDGSTCTKNYGSF-----------T 705

  Fly   931 EPNKTLYYVTRIPKGASNIIITQR----GYPDQNFIVLTDDRDNELLNGKFLKTYPLKF---VYA 988
            :|......|..||.||:||:|.|.    ...|..::.|.....:..|||.:: ..|.:.   :..
Frog   706 KPRYGYNNVVTIPAGATNILIRQNSGSSSTSDGVYLALKRQDGSYALNGNYI-LVPSELDVGIGG 769

  Fly   989 GVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKP-----PDY 1048
            |.:::|:|::..||.:  .....|...|.||  :|.||.   |....|.|::.:.||     |..
Frog   770 GASVRYSGATKAVETI--VGRGPLKEPLTVQ--ALVVSD---QRVPRLKYTFFVPKPTVRSSPPK 827

  Fly  1049 EAEVEIYRWEMQAPSNCDSLCEGR-SHR 1075
            :|..|   |..:.....|.|...| ||:
Frog   828 KATDE---WSKRRAQIMDILRRTRNSHK 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	26/110 (24%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	75/217 (35%)
		Reprolysin	457..655	CDD:279729	75/215 (35%)
		Salp15	<696..745	CDD:288931	19/51 (37%)
		TSP1	754..806	CDD:214559	36/51 (71%)
		ADAM_spacer1	937..1042	CDD:283607	30/111 (27%)
		TSP1	1172..1229	CDD:214559
		GON	1495..1687	CDD:285848
adamts4	XP_004919795.1	Pep_M12B_propep	41..174	CDD:366707	33/151 (22%)
		ZnMc_ADAMTS_like	225..437	CDD:239801	77/221 (35%)
		ADAM_CR_2	451..519	CDD:375321	30/70 (43%)
		ADAM_CR	502..671	CDD:387620	85/169 (50%)
		TSP1	543..586	CDD:214559	31/42 (74%)
		ADAM_spacer1	702..817	CDD:368694	32/133 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7711
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010