DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and adamts18

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_012817732.1	Gene:	adamts18 / 100487298	XenbaseID:	XB-GENE-986196	Length:	1248	Species:	Xenopus tropicalis

Alignment Length:	1325	Identity:	373/1325 - (28%)
Similarity:	567/1325 - (42%)	Gaps:	278/1325 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 FVMPTKVYNYSLSEA----DLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNLN 299
            ||.|.:|   .:|.|    |:::.|::.....|    |.|:.                  .|..:
Frog    89 FVTPIEV---DISGAYVSHDILHISRKRRSARS----SKSSL------------------HYRFS 128

  Fly   300 VFGRQLHLVLRQDASFVHNHSMTHIRIL-KEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHSMV 363
            .||::|||.|:|.:......   ::::| |.|       :..:.||....|||.|::.|..:|.|
Frog   129 AFGQELHLELQQSSVLSDEF---YVQVLGKNG-------SITDVEQEAASCFYQGFIRDYENSTV 183

  Fly   364 SVSLCGGMTGYIKTSFGALLIQPV--------NRTSSD-EVLHRVFRKSQR-------------N 406
            :||.|.||:|:::|......|.|:        |.||.| ...|.::::|..             |
Frog   184 AVSTCDGMSGFLRTHTSEFFISPLPQHLAEKHNYTSPDGHHPHVLYKRSAEVKVAPNKAYSNPAN 248

  Fly   407 ARH-AVSKFELGLDDFMSK------------------LEQVQEEEQKSKSRKLNRKKRHYADVDN 452
            .:| |.|:..|.....:.|                  ..:..|.|..|::::...|.:|...:
Frog   249 EKHPARSEQTLSGSQTLQKHFCGRRNKHSQKLLTKNAYVRADEYENLSRAKRSATKSQHSGGL-- 311

  Fly   453 QVYTLEVLIAVDNSMKQFHGED-LQPYILILMSIVSSIFADASIGNSIRILLVRLISLPN----- 511
               .:|.|:..|..|...||:| :..|||.:|::|||:|.|.:||..|.|::|.|:.|.:
Frog   312 ---VVETLVVADKKMVDKHGKDSVTTYILTVMNMVSSLFKDGTIGTDISIVVVSLLLLEDEQAGF 373

  Fly   512 -INDQTHSSNEMLKHFCQF----INQSGYERDTAMLITREPICGSVPGKICHMLGLAELGTVCSS 571
             ||   |.:::.|.:|||:    ..:.|...|.|:|:|...|| |...:.|..||.|.:..:||.
Frog   374 TIN---HHADQSLNNFCQWQSALTGKHGKRHDHAILLTGLDIC-SWKNEPCDTLGFAPINGMCSK 434

  Fly   572 -SSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSW 635
             .||:|.:||||..|||:|||.||...|.||.:..  |....:.|     |||..:..:...:||
Frog   435 YRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGN--PCGKAEGN-----IMSPTLTGNNGLFSW 492

  Fly   636 SKCSRHFVSEFLEKTDKSCL--ETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP---TD 695
            |.|||.::.:||.....:||  |.....|..| .::|||:||..|.||:..||.....|.   ..
Frog   493 SACSRQYLKKFLSTAQSACLIDEPKQSGHFKY-PDKLPGQIYDADTQCKWQFGPRAKQCSLSFVK 556

  Fly   696 EECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVS-NKHGYGRQVNGGWGPWTP 759
            :.||.|||::    :..:|.:..:|.|:||.||.: .||:||:||. ..|| .:.|||.|..|:.
Frog   557 DICKSLWCHK----AGHRCETKFMPAAEGTVCGLN-MWCRRGQCVRFGDHG-PKPVNGAWSDWSD 615

  Fly   760 FTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRN 824
            ::.||..|||||....|.||:|.|:.|||:|.||.:.|:.||...|||.::|.|.|||...|.:
Frog   616 WSECSRKCGGGVMYQERHCNKPKPQYGGKFCQGSSRIYQLCNIQSCPPNTVDFRAQQCAEYNSK- 679

  Fly   825 MNIPGVNPDTKWVPKY-------EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGI 882
                   |...|..|:       |::.|||:|..:....:|.:.:.|.|||.|:...:|.|::|.
Frog   680 -------PFRGWYYKWKPYTRVEEENICKLYCTAEDFDFFFAMSNKVKDGTPCSTTGYDVCIDGS 737

  Fly   883 CRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYY-VTRIPKGA 946
            |...|||..|.|.|.||.||||:|.|.||....|..|          |:.....|| |..:|.||
Frog   738 CELVGCDYVLGSKATLDACGVCKGDNSTCTFYRGQYL----------NQHKTNGYYSVVTVPAGA 792

  Fly   947 SNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTY-SW 1010
            .:|.:.:... ..:::.:.:.:....|...:...:|.||.:||....|..|   .:|..:.| :.
Frog   793 RSIHVREHEV-STSYLAVRNLKKKYYLTADWTIDWPGKFSFAGTIFNYQRS---FQQPESIYAAG 853

  Fly  1011 KLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAE------VEIYRWEMQAPSNCDSLC 1069
            ..:..|:.:|:    ...|.|.   |::.||:   |:...|      .:.:.| ....|.|...|
Frog   854 PTNETLVFEIL----FQGKNQG---LTWEYTL---PNSVKENTTTIITKNFSW-FSVYSGCSVTC 907

  Fly  1070 EGRSHRLP--ACISTTQGVKVAPQFCDKSAMPKIDDRACNTD-CRLNLTVTSISECSAACGELGT 1131
             |..|.:.  .||. ...::|....|...|.|....:.||.. |....:|:..|.||.:||. |.
Frog   908 -GGGHMMAKLVCIQ-DHYIQVDSSLCALQAKPHSVPKVCNDQPCPAYWSVSEWSSCSVSCGG-GQ 969

  Fly  1132 REKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECR-EGC---WVLSEWSTCSKSCGTGSQQR 1192
            :.:...|||. |.||...:|..|.|.:. ..:..:.|. :.|   |....||.||:|||.|.::|
Frog   970 QTRQIQCVQK-TLMQTEMLVGHSQCPVS-TPSQVQACNVQDCPAEWSSGPWSQCSRSCGKGMKKR 1032

  Fly  1193 EAHCYLHNSR----VSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNE 1253
            |..|...||.    :.::||..:.||.        :||||               |:..
Frog  1033 EVFCRSMNSGKYKILPENLCPMQAKPE--------STESC---------------VLAR------ 1068

  Fly  1254 WCEKTRSVSCSHPYGIGCGSRKPKDVRKCCHIKY---TSDWTDCSVQCGEGVKRKKQSCTRVYKP 1315
             |:|                          |.|.   .|.||:||..||.|||:::..|  |.|.
Frog  1069 -CQK--------------------------HDKLQWAISAWTECSATCGPGVKKRELKC--VEKD 1104

  Fly  1316 D----VPGTRKRRVYVDESYCISRKVHRPKLRTTTKS--CRINCK------WNASDWRRCPADCS 1368
            .    :|...||        |.|.|.....|.....|  |.::..      |:||.|::|...|.
Frog  1105 SHGKLIPFPLKR--------CRSVKKVNIALEQPCNSAPCPVHTPYSTFNGWHASPWQQCSVTCG 1161

  Fly  1369 EEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICN--NCVRRQSRVISQCN-----CEGVEKRR 1426
            ...|:|.|:|..   .|.....|...::|...:.||  .|...:::..:.|.     |..| .:.
Frog  1162 GGVQSRSVQCVH---QGRPAAGCLPYQKPPTSQACNIHFCPTSETQESASCIDYYSWCSLV-PQH 1222

  Fly  1427 DFCFNSHKGRIACPTRARVERHSCT 1451
            ..|.:...|:..|.:.||.:.:..|
Frog  1223 GVCNHKFYGKQCCKSCARKKNYRDT 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	33/117 (28%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	75/211 (36%)
		Reprolysin	457..655	CDD:279729	75/209 (36%)
		Salp15	<696..745	CDD:288931	18/49 (37%)
		TSP1	754..806	CDD:214559	23/51 (45%)
		ADAM_spacer1	937..1042	CDD:283607	23/106 (22%)
		TSP1	1172..1229	CDD:214559	22/63 (35%)
		GON	1495..1687	CDD:285848
adamts18	XP_012817732.1	Pep_M12B_propep	90..229	CDD:366707	44/173 (25%)
		ZnMc_ADAMTS_like	313..512	CDD:239801	75/209 (36%)
		ADAM_CR_2	529..596	CDD:375321	26/71 (37%)
		TSP1	610..662	CDD:214559	23/51 (45%)
		ADAM_spacer1	767..879	CDD:368694	27/135 (20%)
		TSP1	953..1010	CDD:214559	17/59 (29%)
		TSP1	1012..1069	CDD:214559	23/86 (27%)
		TSP1	1077..1137	CDD:214559	21/69 (30%)
		TSP1	1151..1199	CDD:214559	13/50 (26%)
		PLAC	1209..1238	CDD:370061	6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49234
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010