DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and adamts17

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_004912721.1	Gene:	adamts17 / 100380150	XenbaseID:	XB-GENE-6460749	Length:	1131	Species:	Xenopus tropicalis

Alignment Length:	1234	Identity:	330/1234 - (26%)
Similarity:	511/1234 - (41%)	Gaps:	230/1234 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 VMPTKVYNYSLSEADLIYESK----RNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQY-NLN 299
            |:|..|:.   ::.||.|..:    |||      ::..|....||.|         |...| .|.
Frog    24 VIPKVVWP---ADTDLPYRGEGPNYRNS------RKPRSVLGDTGNY---------PDILYIQLP 70

  Fly   300 VFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHSMVS 364
            :..|.|:|.|::|      |.......:.|.:...|...:.:.....| |||:|.|.:...|..|
Frog    71 LASRNLYLNLQRD------HHFLAPGFVVEEKTRDGNTIKRQTLLDEL-CFYTGQVLNHSSSFAS 128

  Fly   365 VSLCGGMTGYIKTSFGALLIQPVNRTSSDE------------------VLHRVFRKSQRNARHAV 411
            :|.|.|:||||......|:|||:|.|:..:                  :.|.....::||. |.|
Frog   129 ISTCAGLTGYIHVGEEQLMIQPINSTAESKFPLSGREHIIRRKRSVPSISHIQLNGARRNC-HVV 192

  Fly   412 SKFELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-EDL 475
            |.               ::::|:.:....:.:.|..|...|:.:|:|.|:..|:.|.|:|| |..
Frog   193 SG---------------KKKKQRKREEGEDWRGRRNAIRLNEEHTVETLVVADSDMVQYHGAEAA 242

  Fly   476 QPYILILMSIVSSIFADASIGNSIRILLVRLI---SLPNINDQTHSSNEMLKHFCQFINQSGYER 537
            |.:||.:|::|.::|...|:|..:.|.:.:|:   |.|......|.....|:.||.:.|:....:
Frog   243 QRFILTVMNMVYNLFQHQSLGIKVNIRVTKLVLLHSRPARLSIGHHGERSLESFCHWQNEEHGSK 307

  Fly   538 ----------------DTAMLITREPICGSVPGKICHMLGLAELGTVCSSS-SCSIVQDTGLPTA 585
                            |.|:.:||...|.. ..:.|..:|:|.||..||:. .|.:.:|.||..|
Frog   308 YLGNNQVPGAKDDIPVDVAVFMTRTDFCVH-KDEPCDTVGIAYLGGACSAKRKCVLAEDNGLNLA 371

  Fly   586 FTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSS--VMGIHMHPWSWSKCSRHFVSEFLE 648
            ||:||||||.:.|:||||.   |....::     ||||.  |.|......|||.|||..:..||:
Frog   372 FTVAHELGHNMGMSHDDDH---PSCAGRS-----HIMSGEWVKGRSPSDLSWSTCSRDDLENFLK 428

  Fly   649 KTDKSCL-----ETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEE--CKRLWCNRT 706
            ....|||     .:.....:|:   :|||..||...|||:.||::..:|...|.  |..||| ..
Frog   429 SKVSSCLLVTDPRSHYAVRLPH---KLPGMHYSASEQCQILFGSNATFCKNMEHLMCAGLWC-LV 489

  Fly   707 SGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGV 771
            .|:|:  |.:...|..|||.||:. .||:.|:|| .|....:.|:|.|..|:.::.||.|||.|.
Frog   490 EGDSS--CKTKLDPPLDGTECGAD-KWCRAGECV-GKTPIPQHVDGDWSAWSSWSMCSRTCGTGA 550

  Fly   772 QESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCY----AMNGRNMNIPGVNP 832
            :..:|:|:.|.|..||:.|.|:..::..|....||.|....|:.||.    :.|.:...:..|..
Frog   551 RFRQRKCDNPPPGPGGRSCRGASVEHMVCENLPCPKGVSSFRDHQCQSHDRSSNKKKSPLTAVII 615

  Fly   833 DTKWVPKYEKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAK 897
            |.:        .|:|||....:.|..::...|.|||.|.....|.||:|.|:..|||..:.|.||
Frog   616 DDR--------PCELFCTPVGRDTPVLMADRVLDGTPCGPYEIDLCVHGRCQKIGCDGIIGSSAK 672

  Fly   898 LDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNK----------------TLYY-VTRIPKG 945
            .|:||:|.|...||..|.|:.  ::..|:...:...|                |.|. ...||.|
Frog   673 EDRCGICNGDGKTCKVVKGDF--NHTKGMVTSSHCKKVSTCVMTKAKAVAKCFTCYIEAAVIPAG 735

  Fly   946 ASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSW 1010
            |..|.:.: ..|..:|:.|.|. ..:.:|..:....|.:|..||.|::|. ...:.|:::.....
Frog   736 ARRIRVVE-DKPAHSFLALKDS-IKKSINSDWKIELPGEFQIAGTTIRYV-RRGLWEKISAKGPT 797

  Fly  1011 KLSRDLIVQIISLDVSPSKRQDTVLLSYSYTI------DKPPDYEAEVE-IYRWEMQAPSNCDSL 1068
            |....|:|.:.        ......:.|.|||      ::.|:.|.:.: :|.|.......|...
Frog   798 KTPLHLMVLLF--------HDQNYGIHYEYTIPVNQSSEQKPEPEKQPDPMYMWTHSGWEGCSVQ 854

  Fly  1069 CEGRSHRLPACISTTQGVK-----VAPQFCDKSAMPKIDDRACNT-DCRLNLTVTSISECSAACG 1127
            |.|...|  ..:|.|:.|.     |....|..::.|....|.||. .|:......:.::||:.|
Frog   855 CGGGERR--TVVSCTKIVNKTMVIVNDSLCLHTSRPVPQVRKCNVHPCQSRWVAGTWNQCSSTC- 916

  Fly  1128 ELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECR-EGC---WVLSEWSTCSKSCGTG 1188
            :.|.:.:...||....|....|..|. || |....|..:.|. :.|   |..||||.||..||.|
Frog   917 DRGFQLREVTCVFQLQNGTFVNTQDF-YC-LGPKPATRQICEGQDCLSIWEASEWSKCSSDCGRG 979

  Fly  1189 SQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNE 1253
            :::|...|  .||:   ..|:..|:|...        |.|..||      ....|..|:|.:|:.
Frog   980 TKKRRISC--SNSK---GKCDSATRPRAE--------EECEDYT------GCYEWKTGDWSKCSS 1025

  Fly  1254 WCEK---TRSVSCSHP----YGIGCG-SRKPKDVRKCCHIKYTSDWTDCSVQCGEGVKRKKQSCT 1310
            .|.|   :|.|.|.|.    :|..|. ..||...|: ||.:..:|..:.:......:......||
Frog  1026 TCGKGLQSRVVQCMHKVTGRHGNECAIISKPVAYRQ-CHQEACNDKVNANTITSPRLAALTYKCT 1089

  Fly  1311 RVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINCKWNASDWRRCPADCSEEYQTR 1374
                             .:.:.:..:|.|.|     ..|: :.:|    ::||...|.:.|..:
Frog  1090 -----------------GDQWTVYCRVIREK-----NLCQ-DMRW----YQRCCQTCRDFYANK 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	32/108 (30%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	72/222 (32%)
		Reprolysin	457..655	CDD:279729	71/220 (32%)
		Salp15	<696..745	CDD:288931	20/50 (40%)
		TSP1	754..806	CDD:214559	17/51 (33%)
		ADAM_spacer1	937..1042	CDD:283607	23/105 (22%)
		TSP1	1172..1229	CDD:214559	19/59 (32%)
		GON	1495..1687	CDD:285848
adamts17	XP_004912721.1	Pep_M12B_propep	22..168	CDD:366707	45/168 (27%)
		ZnMc_ADAMTS_like	221..436	CDD:239801	73/223 (33%)
		ADAM_CR_2	453..520	CDD:375321	27/70 (39%)
		TSP1	533..585	CDD:214559	17/51 (33%)
		ADAM_spacer1	726..822	CDD:368694	24/106 (23%)
		TSP1	964..1008	CDD:214559	19/56 (34%)
		TSP1	1015..1067	CDD:214559	17/52 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920