Protein Alignment AdamTS-A and adamts12

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: XP_017946319.2
• Gene: adamts12 / 100380018
• XenbaseID: XB-GENE-959575
• Length: 1569
• Species: Xenopus tropicalis
• Alignment Length: 1687
• Identity: 414/1687 - (24%)
• Similarity: 626/1687 - (37%)
• Gaps: 503/1687 - (29%)

  Fly   181 LRSAHKGQEELPQSTHPLANSPPATPATLHPRRLDNDTSTDHEPPDGLDDLDEEEHSAF--VMPT 243
            ||.:|....|.|...:.:..:.|...|..|..||..|  ..|....|.:.||.....||  |.|.
 Frog     8 LRPSHAMYAERPACRYFIFCTFPLLLAICHGTRLHRD--NPHSLHKGQEHLDHSLPLAFEVVEPV 70

  Fly   244 KV------YNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNL--NV 300
            ||      .:|:|       :.:|        |.|.::.|:  .||       ..|..:||  |:
 Frog    71 KVDEKGNFLSYNL-------QHRR--------KRSVASQAI--HYR-------IHHKTHNLFFNL 111

  Fly   301 FGRQLHLVLRQDASFV---HNHSMTHIRILKE-GEEHPGPETEAEAEQRHLGCFYSGYVEDDPHS 361
            ..|...|    ..:|:   .|.:.:|.||..: |.   |......|::.|:|           ..
 Frog   112 TFRDGFL----SDNFILERRNGNSSHARISPQLGN---GCHLIGTAQRAHVG-----------GG 158

  Fly   362 MVSVSLCGGMTGYIKTSFGALLIQP---VNRTSSDEVLHRVFRKS--QRNARHAVSKFELGLDDF 421
            :.::|:|.|:.|:.:...|...|:|   ..:.|.....|.::::.  .||.|    :..:...||
 Frog   159 VAAISVCNGLAGFFRLPDGDYFIEPFHGATQVSGKPHQHIIYQRDSPHRNRR----ELPISTGDF 219

  Fly   422 M-----SKLEQVQEEEQKSKSRK-LNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-EDLQPYI 479
            .     ||....||.:::...|| ||.:|.....|..:.: :|.|:..|..|..:|| .:::.||
 Frog   220 CAVNDNSKSVLQQERQREEWERKHLNGRKISQRSVSKERW-VETLVVADTKMIAYHGSNNVESYI 283

  Fly   480 LILMSIVSSIFADASIGNSIRILLVRLISLPNINDQ---THSSNEMLKHFCQF---INQSG---- 534
            ..:|::|:.:|.|.:|||:|.|.:||||.|....:.   .|::::.|..||::   ||...
 Frog   284 FTIMNMVTGLFHDPNIGNAIHIKVVRLILLEEEEEGLKIVHNADQTLASFCKWQKSINPKSDAHP 348

  Fly   535 YERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNM 598
            ...|.|:|:||:.||.| ....|..|||:.|..:|. |.||:|.:|||||.|||:||||||...:
 Frog   349 AHHDVAVLLTRKDICAS-KNSPCETLGLSHLSGMCQPSKSCNINEDTGLPLAFTIAHELGHSFGI 412

  Fly   599 NHDDDDKCMPYVTRQNNNKVL-----HIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETS 658
            .||.          |.|:..:     :|||..:..:..|.:||.||:.:::.||::....||:
 Frog   413 QHDG----------QGNDCEIAGRNPYIMSRQLQYNTSPLTWSPCSKEYITRFLDRGWGFCLD-- 465

  Fly   659 VGAHIPYGTER-----LPGEIYSLDAQCQLSFGNDFGYC-PTDEECKRLWCNRTSGNSNEQCASS 717
               .:|...:.     .||.:|.::.||||.:|.:..:| ..|..|:.|||     :....|.|.
 Frog   466 ---DVPAKKDLKPPIIAPGVLYDVNHQCQLQYGPNATFCEEVDNVCQTLWC-----SVKNSCRSK 522

  Fly   718 NLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPV 782
            ....||||.||.| .||..|||: |.....:.:|||||.|||::.||.|||.|.:.:.|:||.|.
 Frog   523 LDSAADGTRCGES-KWCFNGKCI-NVGTTPQTINGGWGAWTPWSHCSRTCGAGAENAERKCNNPQ 585

  Fly   783 PENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE-KDACK 846
            |:.|||||||.||:||.||...||......||.||...|    .:|..|...:|:|.|. ::.|:
 Frog   586 PKFGGKYCTGERKRYRICNIQPCPKDYPSFREMQCTEFN----TVPYKNELYQWIPIYNTENPCE 646

  Fly   847 LFCRMDMKVTYFMLKSMVTDGTSC--AVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRND 909
            |.||.............|.|||.|  ...|.|.|:||||:..|||.|::|.|..|:||:|.|...
 Frog   647 LHCRSSSGNFANKFLDAVIDGTPCFERNKSRDVCINGICKKVGCDYEIDSNATEDRCGICLGDGS 711

  Fly   910 TCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIII---TQRGYPDQNFIVL-TDDRDN 970
            :|..:......::..|..|          |..|||||.:|.|   .:.|    ||:.| ::|...
 Frog   712 SCQTIKKVFNQTDGFGYVD----------VGLIPKGARDIKIEEVEEAG----NFLALRSEDPGK 762

  Fly   971 ELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVL 1035
            ..|||.::..:..::..||....|..::   :..|.|.|...:..:.:|::..:.:|..|
 Frog   763 YYLNGAYIIQWNGEYKVAGTIFHYQRNN---DTENITASGPTNESIWIQLLFQEHNPGVR----- 819

  Fly  1036 LSYSYTIDKPPDYEAEVE-IYRWEMQAPSNCDSLC-EGRSHRLPACISTTQGVKVAPQFCDKSAM 1098
              |.|.|.|..:.|.|:| :|.|.....::|.:.| .|..|::..|::..:|| |...|||:...
 Frog   820 --YEYVIQKDVNLENEIESVYTWRYGGWTDCSATCGTGVQHQISRCVNKKRGV-VKNTFCDQEMQ 881

  Fly  1099 PKIDDRACNT-DCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDV 1162
            |....:.||| :|.....|....:||..||..|.:::|..|::|..:.:.:         |:.:.
 Frog   882 PITRQKKCNTKECPPRWWVGQWQQCSTTCGPTGEKKRTVLCLKTSGSDEEA---------LRSED 937

  Fly  1163 AYH-------EECREG--C---WVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDD--------L 1207
            .:|       ..|...  |   |.:|.||.||.:||.|.:.|...|..:|....|.        |
 Frog   938 CHHLTKPKVYLSCNRDILCPSDWTVSNWSECSVTCGGGVRTRNITCAKNNDEPCDSSKKPNSKAL 1002

  Fly  1208 C---------------------------------------------------------------- 1208
            |
 Frog  1003 CGLQQCYVQKTLPKPPIKYNYRKKIIKKKSGDPKRRIFLPNKNHRVQTTTGLPRVFMSTSSTNSS 1067

  Fly  1209 ----------------------------------NPRTKPHLN-----------TLIG------- 1221
                                              |.:.|.|:|           |.:|
 Frog  1068 SPSVKSIKEDFQINEIPNSTHFNIDYKYNFVLVENNKRKVHVNATSISPSVSNRTKVGNMETGTE 1132

  Fly  1222 -ICNTESCPTY------------------------------------------------------ 1231
             |...:|.|.:
 Frog  1133 SIAEKDSPPIFTTTRRPEELTSKYQLLTEQPQSQTESGNMRGSTVDPNGDYDTDINFIIESRSKR 1197

  Fly  1232 ------------------TKSP---------------NALAVSN--------------------- 1242
                              |:||               |.:::||
 Frog  1198 HKGKTNQNQNHPGTNLNQTESPTNSSILINQTPLSTYNTVSISNTEGNSTRNNQDWRDVAPTASA 1262

  Fly  1243 -------------------------------------------------WVIGEWGECNEWC--- 1255
                                                             |::|.|.||:..|
 Frog  1263 QPSFLQVTTSNTPENSTWKVNNASNRYLLNYTHYENGTGLNFNVSKEVYWIVGNWSECSTSCGLG 1327

  Fly  1256 EKTRSVSCSHPYGIGCGSRKPKDVRKCCHIK-----YTSDWTDCSVQCGEGVKRKKQSCTRVYKP 1315
            ...|.|.||..:...|...|..|..:.||::     .|.|||.||..|..|.|.::..|.
 Frog  1328 AMWRPVDCSTEFDDDCKHIKKPDPARRCHLRPCARWETGDWTKCSKNCQGGFKTREVQCV----- 1387

  Fly  1316 DVPGTRKRRVYVDESYCIS-RKVHRPKLRTTTKSCRINCKWNASDWRRCPADCSEEYQTRDVRCE 1379
            |:...|..|.:    :|.| .|.....:...|:.|   ..|.|..|..|...|....:.|.|.|.
 Frog  1388 DIRENRPLRPF----HCQSPGKNPEQNVSCNTEPC---LSWLAKPWSECSKTCGGGIRQRQVLCP 1445

  Fly  1380 SFQGDGVEDKHCDAKKRPSKRRICNN--CVRRQSRVISQCN--CEGVEKRRDF-CFNSHKGRIA- 1438
            .      ||: ||.||.|.....||:  |.|.......:|:  |.|..:||.. |.|:|.....
 Frog  1446 K------EDR-CDWKKIPPVSLPCNDEPCTRWNISSWMECSVPCGGGTQRRTVECINTHNNSTVH 1503

  Fly  1439 ---CP-TRARVERHSCTPPPHCRRRSAIGSSISSRPRGTGVSSSRSLNSIGGSRNRGTPRSC 1496
               |. |.|:..:......|.|:|.:   ...:.:.....|:..|::.|||....:.....|
 Frog  1504 QDLCQRTEAKPRQTQECNQPECQRNA---EDPACKRDKMSVNFCRTVKSIGRCSVKSIQTQC 1562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	23/107 (21%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	74/216 (34%)
		ADAMTS_CR_2	671..740	CDD:465496	27/69 (39%)
		TSP1	754..806	CDD:214559	29/51 (57%)
		ADAMTS_CR_3	815..911	CDD:437068	35/98 (36%)
		TSP1	1172..1229	CDD:214559	24/184 (13%)
		TSP1_ADAMTS	1243..1282	CDD:465950	13/41 (32%)
		TSP1_ADAMTS	1355..1405	CDD:465950	16/49 (33%)
		GON	1493..1687	CDD:462559	1/4 (25%)
adamts12	XP_017946319.2	Pep_M12B_propep	65..200	CDD:460254	37/176 (21%)
		ZnMc_ADAMTS_like	258..465	CDD:239801	75/218 (34%)
		ADAMTS_CR_2	480..544	CDD:465496	27/69 (39%)
		TSP1	557..609	CDD:214559	29/51 (57%)
		ADAMTS_CR_3	615..713	CDD:437068	37/101 (37%)
		ADAMTS_spacer1	715..824	CDD:461796	29/132 (22%)
		TSP1_ADAMTS	840..894	CDD:465950	16/54 (30%)
		TSP1_ADAMTS	898..952	CDD:465950	12/62 (19%)
		TSP1_ADAMTS	960..1008	CDD:465950	15/47 (32%)
		TSP1_ADAMTS	1312..1360	CDD:465950	15/47 (32%)
		TSP1_ADAMTS	1363..1418	CDD:465950	17/63 (27%)
		TSP1_ADAMTS	1421..1467	CDD:465950	17/52 (33%)
		TSP1_ADAMTS	1470..1525	CDD:465950	12/54 (22%)