DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and adamts12

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:XP_017946319.2 Gene:adamts12 / 100380018 XenbaseID:XB-GENE-959575 Length:1569 Species:Xenopus tropicalis


Alignment Length:1687 Identity:414/1687 - (24%)
Similarity:626/1687 - (37%) Gaps:503/1687 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 LRSAHKGQEELPQSTHPLANSPPATPATLHPRRLDNDTSTDHEPPDGLDDLDEEEHSAF--VMPT 243
            ||.:|....|.|...:.:..:.|...|..|..||..|  ..|....|.:.||.....||  |.|.
 Frog     8 LRPSHAMYAERPACRYFIFCTFPLLLAICHGTRLHRD--NPHSLHKGQEHLDHSLPLAFEVVEPV 70

  Fly   244 KV------YNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNL--NV 300
            ||      .:|:|       :.:|        |.|.::.|:  .||       ..|..:||  |:
 Frog    71 KVDEKGNFLSYNL-------QHRR--------KRSVASQAI--HYR-------IHHKTHNLFFNL 111

  Fly   301 FGRQLHLVLRQDASFV---HNHSMTHIRILKE-GEEHPGPETEAEAEQRHLGCFYSGYVEDDPHS 361
            ..|...|    ..:|:   .|.:.:|.||..: |.   |......|::.|:|           ..
 Frog   112 TFRDGFL----SDNFILERRNGNSSHARISPQLGN---GCHLIGTAQRAHVG-----------GG 158

  Fly   362 MVSVSLCGGMTGYIKTSFGALLIQP---VNRTSSDEVLHRVFRKS--QRNARHAVSKFELGLDDF 421
            :.::|:|.|:.|:.:...|...|:|   ..:.|.....|.::::.  .||.|    :..:...||
 Frog   159 VAAISVCNGLAGFFRLPDGDYFIEPFHGATQVSGKPHQHIIYQRDSPHRNRR----ELPISTGDF 219

  Fly   422 M-----SKLEQVQEEEQKSKSRK-LNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-EDLQPYI 479
            .     ||....||.:::...|| ||.:|.....|..:.: :|.|:..|..|..:|| .:::.||
 Frog   220 CAVNDNSKSVLQQERQREEWERKHLNGRKISQRSVSKERW-VETLVVADTKMIAYHGSNNVESYI 283

  Fly   480 LILMSIVSSIFADASIGNSIRILLVRLISLPNINDQ---THSSNEMLKHFCQF---INQSG---- 534
            ..:|::|:.:|.|.:|||:|.|.:||||.|....:.   .|::::.|..||::   ||...    
 Frog   284 FTIMNMVTGLFHDPNIGNAIHIKVVRLILLEEEEEGLKIVHNADQTLASFCKWQKSINPKSDAHP 348

  Fly   535 YERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNM 598
            ...|.|:|:||:.||.| ....|..|||:.|..:|. |.||:|.:|||||.|||:||||||...:
 Frog   349 AHHDVAVLLTRKDICAS-KNSPCETLGLSHLSGMCQPSKSCNINEDTGLPLAFTIAHELGHSFGI 412

  Fly   599 NHDDDDKCMPYVTRQNNNKVL-----HIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETS 658
            .||.          |.|:..:     :|||..:..:..|.:||.||:.:::.||::....||:  
 Frog   413 QHDG----------QGNDCEIAGRNPYIMSRQLQYNTSPLTWSPCSKEYITRFLDRGWGFCLD-- 465

  Fly   659 VGAHIPYGTER-----LPGEIYSLDAQCQLSFGNDFGYC-PTDEECKRLWCNRTSGNSNEQCASS 717
               .:|...:.     .||.:|.::.||||.:|.:..:| ..|..|:.|||     :....|.|.
 Frog   466 ---DVPAKKDLKPPIIAPGVLYDVNHQCQLQYGPNATFCEEVDNVCQTLWC-----SVKNSCRSK 522

  Fly   718 NLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPV 782
            ....||||.||.| .||..|||: |.....:.:|||||.|||::.||.|||.|.:.:.|:||.|.
 Frog   523 LDSAADGTRCGES-KWCFNGKCI-NVGTTPQTINGGWGAWTPWSHCSRTCGAGAENAERKCNNPQ 585

  Fly   783 PENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE-KDACK 846
            |:.|||||||.||:||.||...||......||.||...|    .:|..|...:|:|.|. ::.|:
 Frog   586 PKFGGKYCTGERKRYRICNIQPCPKDYPSFREMQCTEFN----TVPYKNELYQWIPIYNTENPCE 646

  Fly   847 LFCRMDMKVTYFMLKSMVTDGTSC--AVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRND 909
            |.||.............|.|||.|  ...|.|.|:||||:..|||.|::|.|..|:||:|.|...
 Frog   647 LHCRSSSGNFANKFLDAVIDGTPCFERNKSRDVCINGICKKVGCDYEIDSNATEDRCGICLGDGS 711

  Fly   910 TCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIII---TQRGYPDQNFIVL-TDDRDN 970
            :|..:......::..|..|          |..|||||.:|.|   .:.|    ||:.| ::|...
 Frog   712 SCQTIKKVFNQTDGFGYVD----------VGLIPKGARDIKIEEVEEAG----NFLALRSEDPGK 762

  Fly   971 ELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVL 1035
            ..|||.::..:..::..||....|..::   :..|.|.|...:..:.:|::..:.:|..|     
 Frog   763 YYLNGAYIIQWNGEYKVAGTIFHYQRNN---DTENITASGPTNESIWIQLLFQEHNPGVR----- 819

  Fly  1036 LSYSYTIDKPPDYEAEVE-IYRWEMQAPSNCDSLC-EGRSHRLPACISTTQGVKVAPQFCDKSAM 1098
              |.|.|.|..:.|.|:| :|.|.....::|.:.| .|..|::..|::..:|| |...|||:...
 Frog   820 --YEYVIQKDVNLENEIESVYTWRYGGWTDCSATCGTGVQHQISRCVNKKRGV-VKNTFCDQEMQ 881

  Fly  1099 PKIDDRACNT-DCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDV 1162
            |....:.||| :|.....|....:||..||..|.:::|..|::|..:.:.:         |:.:.
 Frog   882 PITRQKKCNTKECPPRWWVGQWQQCSTTCGPTGEKKRTVLCLKTSGSDEEA---------LRSED 937

  Fly  1163 AYH-------EECREG--C---WVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDD--------L 1207
            .:|       ..|...  |   |.:|.||.||.:||.|.:.|...|..:|....|.        |
 Frog   938 CHHLTKPKVYLSCNRDILCPSDWTVSNWSECSVTCGGGVRTRNITCAKNNDEPCDSSKKPNSKAL 1002

  Fly  1208 C---------------------------------------------------------------- 1208
            |                                                                
 Frog  1003 CGLQQCYVQKTLPKPPIKYNYRKKIIKKKSGDPKRRIFLPNKNHRVQTTTGLPRVFMSTSSTNSS 1067

  Fly  1209 ----------------------------------NPRTKPHLN-----------TLIG------- 1221
                                              |.:.|.|:|           |.:|       
 Frog  1068 SPSVKSIKEDFQINEIPNSTHFNIDYKYNFVLVENNKRKVHVNATSISPSVSNRTKVGNMETGTE 1132

  Fly  1222 -ICNTESCPTY------------------------------------------------------ 1231
             |...:|.|.:                                                      
 Frog  1133 SIAEKDSPPIFTTTRRPEELTSKYQLLTEQPQSQTESGNMRGSTVDPNGDYDTDINFIIESRSKR 1197

  Fly  1232 ------------------TKSP---------------NALAVSN--------------------- 1242
                              |:||               |.:::||                     
 Frog  1198 HKGKTNQNQNHPGTNLNQTESPTNSSILINQTPLSTYNTVSISNTEGNSTRNNQDWRDVAPTASA 1262

  Fly  1243 -------------------------------------------------WVIGEWGECNEWC--- 1255
                                                             |::|.|.||:..|   
 Frog  1263 QPSFLQVTTSNTPENSTWKVNNASNRYLLNYTHYENGTGLNFNVSKEVYWIVGNWSECSTSCGLG 1327

  Fly  1256 EKTRSVSCSHPYGIGCGSRKPKDVRKCCHIK-----YTSDWTDCSVQCGEGVKRKKQSCTRVYKP 1315
            ...|.|.||..:...|...|..|..:.||::     .|.|||.||..|..|.|.::..|.     
 Frog  1328 AMWRPVDCSTEFDDDCKHIKKPDPARRCHLRPCARWETGDWTKCSKNCQGGFKTREVQCV----- 1387

  Fly  1316 DVPGTRKRRVYVDESYCIS-RKVHRPKLRTTTKSCRINCKWNASDWRRCPADCSEEYQTRDVRCE 1379
            |:...|..|.:    :|.| .|.....:...|:.|   ..|.|..|..|...|....:.|.|.|.
 Frog  1388 DIRENRPLRPF----HCQSPGKNPEQNVSCNTEPC---LSWLAKPWSECSKTCGGGIRQRQVLCP 1445

  Fly  1380 SFQGDGVEDKHCDAKKRPSKRRICNN--CVRRQSRVISQCN--CEGVEKRRDF-CFNSHKGRIA- 1438
            .      ||: ||.||.|.....||:  |.|.......:|:  |.|..:||.. |.|:|..... 
 Frog  1446 K------EDR-CDWKKIPPVSLPCNDEPCTRWNISSWMECSVPCGGGTQRRTVECINTHNNSTVH 1503

  Fly  1439 ---CP-TRARVERHSCTPPPHCRRRSAIGSSISSRPRGTGVSSSRSLNSIGGSRNRGTPRSC 1496
               |. |.|:..:......|.|:|.:   ...:.:.....|:..|::.|||....:.....|
 Frog  1504 QDLCQRTEAKPRQTQECNQPECQRNA---EDPACKRDKMSVNFCRTVKSIGRCSVKSIQTQC 1562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 24/116 (21%)
ZnMc_ADAMTS_like 455..655 CDD:239801 74/216 (34%)
Reprolysin 457..655 CDD:279729 74/214 (35%)
Salp15 <696..745 CDD:288931 19/48 (40%)
TSP1 754..806 CDD:214559 29/51 (57%)
ADAM_spacer1 937..1042 CDD:283607 27/108 (25%)
TSP1 1172..1229 CDD:214559 24/184 (13%)
GON 1495..1687 CDD:285848 1/2 (50%)
adamts12XP_017946319.2 Pep_M12B_propep 65..200 CDD:396235 37/176 (21%)
ZnMc_ADAMTS_like 258..465 CDD:239801 75/218 (34%)
ADAM_CR_2 480..544 CDD:407643 27/69 (39%)
ADAM_CR 527..688 CDD:417715 73/166 (44%)
TSP1 557..609 CDD:214559 29/51 (57%)
ADAM_spacer1 714..825 CDD:368694 29/134 (22%)
TSP1_ADAMTS 840..894 CDD:408800 16/54 (30%)
TSP1_ADAMTS 898..952 CDD:408800 12/62 (19%)
TSP1_ADAMTS 960..1008 CDD:408800 15/47 (32%)
TSP1_ADAMTS 1312..1360 CDD:408800 15/47 (32%)
TSP1_ADAMTS 1363..1418 CDD:408800 17/63 (27%)
TSP1_ADAMTS 1421..1467 CDD:408800 17/52 (33%)
TSP1_ADAMTS 1470..1525 CDD:408800 12/54 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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