DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and adamtsl5

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_002932288.1	Gene:	adamtsl5 / 100379976	XenbaseID:	XB-GENE-5867327	Length:	525	Species:	Xenopus tropicalis

Alignment Length:	462	Identity:	134/462 - (29%)
Similarity:	190/462 - (41%)	Gaps:	71/462 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   754 WGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCY 818
            |..|..::|||.|||||.....|.|  .:.:.|...|.|..::|:.|||..||.|..|.|..||.
Frog    57 WSVWHSWSPCSRTCGGGAAVRTRTC--LIRDQGSPMCPGEMRQYQVCNTQDCPSGVADFRHFQCS 119

  Fly   819 AMNGRNMNIPGVNPDTKWVPKYE-KDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGI 882
            |.|.:    |.:....:|||.|. :..|:|.|..:.:..|:.. ..|.|||||..|....|:||.
Frog   120 AYNKK----PLMGNYFRWVPFYSGQSDCELSCLAEGQNFYYNF-GRVLDGTSCHSDYDGLCINGQ 179

  Fly   883 CRPAGCDNELNSIAKLDKCGVCEGRNDTC---HEV-TGNLLVSNLLGLNDGNEPNKTLYYVTRIP 943
            |...|||..|.|..|.|.||||.|:|.:|   |.| |.....|.|.|.|:          ||.||
Frog   180 CLKIGCDLILGSEEKTDICGVCGGKNISCRHYHNVYTTKYPPSGLFGYNE----------VTMIP 234

  Fly   944 KGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTY 1008
            .||:||.:|.|   ..|::.|.:...:.::||.:..:||..:..||..:.|..::...|...:
Frog   235 TGATNIKVTDR---SNNYLALRNRNYHYVINGNWAISYPGVYNVAGTKVHYKRAADNQETFES-- 294

  Fly  1009 SWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRS 1073
            ....|.||.:.::.       .:..:.:.|.|.:  |.||..:.:..|..:|.        .|..
Frog   295 QGPTSEDLHIMVLF-------TEQNLGIEYEYWL--PKDYYIQHQRDRSSLQE--------YGEV 342

  Fly  1074 HRLPACISTTQGV-KVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSI--SECSAACGELGTRE-- 1133
            ...|...||||.. |...|........:...|....:...|....||  |:| ..|.::..|:
Frog   343 SVPPTHPSTTQPTPKTTAQILTHHIKKQPQARLQRENTEWNQVKESIENSKC-GKCKKVKGRQNK 406

  Fly  1134 -KTYACVQTFTNMQR---SNIVDMSYCKLKFDV----AYHEEC----REGCWVLSEWSTCSKSCG 1186
             |.| |.:.|....|   ...|....|   :|:    .|....    ||..||.   :||  .|.
Frog   407 VKQY-CQKDFVFRGRVLSKKTVGKETC---YDIQVVMTYKNNFPILRREYIWVP---NTC--DCP 462

  Fly  1187 TGSQQRE 1193
            ..|::||
Frog   463 YMSEKRE 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559	19/51 (37%)
		ADAM_spacer1	937..1042	CDD:283607	25/104 (24%)
		TSP1	1172..1229	CDD:214559	8/22 (36%)
		GON	1495..1687	CDD:285848
adamtsl5	XP_002932288.1	TSP1	57..107	CDD:214559	19/51 (37%)
		ADAM_spacer1	220..322	CDD:368694	29/125 (23%)
		NTR_like	408..511	CDD:382999	19/71 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910