DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and adamts9

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_001244125.1 Gene:adamts9 / 100333407 ZFINID:ZDB-GENE-070814-6 Length:1643 Species:Danio rerio


Alignment Length:1508 Identity:468/1508 - (31%)
Similarity:675/1508 - (44%) Gaps:316/1508 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   218 TSTDHEPPDGLDDLDEE--------------EHSA-------------------FVMPTKVYNYS 249
            :|..|...:|.::.|.|              ||:|                   ||.|...||..
Zfish    89 SSEGHNSVEGEEEEDTEYQHCFYKGHVNAGQEHTAVISLCSGLLGTFRSPEGEFFVEPLHSYNSE 153

  Fly   250 LSEAD-----LIYE---SKRNSDINSFLKESA-----SAFAM--------------TG------- 280
            ..|.:     ::|.   ||:..|.::..:.||     .|:.:              ||       
Zfish   154 HYEEEHIKPHVVYRKDASKKTVDDSAACETSAKLQEFGAYEIVTPARLNEVGEQLPTGVHFKRRK 218

  Fly   281 -----TYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHN-HSMTHIRILKEGEEHPGPETE 339
                 |..|:|:....||..|.::.||:..:|.|..::.|:.. :::|.:....||......|.:
Zfish   219 RSTDPTTANISHHWTSPHAYYQISAFGQDYYLNLTLESGFIAPVYTVTILGASSEGHNSVEGEED 283

  Fly   340 AEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEV------LHR 398
            .:.|.:|  |||.|:|.........:|||.|:.|..::..|...::|::..:|:..      .|.
Zfish   284 EDTEYQH--CFYKGHVNAGQEHTAVISLCSGLLGTFRSPEGEFFVEPLHSYNSERYEEEHIKPHV 346

  Fly   399 VFRK------------------SQRNARH-------AVSKFELGLDDFMSKL----EQVQEEEQK 434
            |:||                  ::.|.||       :.|.....|:...|:|    |.......:
Zfish   347 VYRKDASKKTVDDSAACETSGHTEPNRRHRNRLKRKSPSSMLSDLETLNSRLFPFSENKHNSANE 411

  Fly   435 SKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSI 499
            |...|.:|:.:.:......|   ||::..|:.|.:.||.:||.|||.||||||||:.|.||||.|
Zfish   412 SSDSKPHRRSKRFLSYPRFV---EVMVVADSKMVEHHGSNLQHYILTLMSIVSSIYKDPSIGNLI 473

  Fly   500 RILLVRLISLPN-INDQTHSSNEM--LKHFCQFINQSGY-------ERDTAMLITREPICGSVPG 554
            .|::|:|:.:.| ::..|.|.|..  ||:||.:.....:       ..|||:||||:.||.:  .
Zfish   474 NIVIVKLVIIKNELDGPTISFNAQATLKNFCIWQQSQNHPDDNHPSHHDTAILITRQDICRA--R 536

  Fly   555 KICHMLGLAELGTVCSS-SSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKV 618
            ..|..||||||||||.. .||||.:|.||.||||:||||||:.||.|||.:||.....:...   
Zfish   537 DKCDTLGLAELGTVCDPYRSCSINEDNGLSTAFTIAHELGHVFNMPHDDSNKCKEDGVKNQQ--- 598

  Fly   619 LHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSC-LETSVGAHIPYG-TERLPGEIYSLDAQC 681
             |:|:..:..:.:||.||||||.:::|||:.....| |:..|..  ||. :::|||:|||::.||
Zfish   599 -HVMAPTLNYYTNPWMWSKCSRKYITEFLDTGYGECLLDEPVSR--PYSLSQQLPGQIYSVNKQC 660

  Fly   682 QLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGY 746
            :|.||.....||...:|:||||....| ....|.:.::||||||.|....| |:.|.|:..:|.|
Zfish   661 ELIFGPGTQVCPYMTQCRRLWCTSPDG-VQRGCRTQHMPWADGTDCAPGKH-CKHGLCIHKEHEY 723

  Fly   747 GRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMD 811
             ..|.|.||.|:||..||.|||||::.:.||||:|||.||||||.|.|.|:||||:..|.....|
Zfish   724 -VPVEGAWGVWSPFGTCSRTCGGGIKIAVRECNRPVPRNGGKYCVGRRMKFRSCNSEPCSKQKKD 787

  Fly   812 PREQQCYAMNGRNMNIPGVNPDTKWVPKYE----KDACKLFCRMDMKVTYFMLKSMVTDGTSCAV 872
            .||:||.:.:||:.||.|:.|:.:|||||.    ||.||||||:.....|:.|:..|||||.|..
Zfish   788 FREEQCASFDGRHFNINGLPPNVRWVPKYSGILMKDRCKLFCRVAGSTAYYQLRDRVTDGTQCGP 852

  Fly   873 DSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLY 937
            |:.|.||.|:||.||||:.|||.|:.||||||.|.|.:|..|.|...:.: .|.|          
Zfish   853 DTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKPVAGTFNIVH-YGYN---------- 906

  Fly   938 YVTRIPKGASNIIITQRGY----PDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAG-VTMQYTGS 997
            .|.|||.||:||.:.|..|    .|.|::.|::.|...||||.|:.:...:.|..| ..::|:||
Zfish   907 VVVRIPSGATNIDVRQHSYSGKAEDDNYLALSNSRGEYLLNGDFVVSMFKREVRVGNAVIEYSGS 971

  Fly   998 SSVVEQVNTTYSWKLSRDLIVQIISLD--VSPSKRQDTVLLSYSYTI---DKPPDYEAEVEIYRW 1057
            ..|||::|.|.  ::..::|:|::|:.  .:|..|       |||.|   |||       :.:.|
Zfish   972 DHVVERINCTD--RIEEEIIIQVLSVGNLYNPDVR-------YSYNIPIEDKP-------QHFFW 1020

  Fly  1058 EMQAP-SNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISE 1121
            :...| .:|..||:|...:...|...:..|.|:.|.|.....|.....:|||||.|...:...||
Zfish  1021 DAYGPWQDCSLLCQGERKKKILCNRESDRVVVSDQRCHGLPKPAAITESCNTDCELGWHIARKSE 1085

  Fly  1122 CSAACGELGTREKTYACVQTFTNMQRSNIVDMSYC----KLKFDVAYHEECREGCWVLSEWSTCS 1182
            |:|||| :|.|.....|.:......::..||..||    |.......|.:|..|.|..|.||.||
Zfish  1086 CTAACG-VGYRSLDIYCTKQSRLDGKTQKVDERYCSSQHKPNDKEVCHGDCNPGGWEYSSWSECS 1149

  Fly  1183 KSCGTGSQQREAHCYLHNSRVSDDLCNPRTK----PHLNTLIGICNTESCPTYTKSPNALAVSNW 1243
            :|||.|:::|.|.|...:.|..|..|||:.|    |        ||...||            .|
Zfish  1150 RSCGGGTRRRNAICGKSDERDDDSKCNPQEKLTAQP--------CNEFLCP------------QW 1194

  Fly  1244 VIGEWGEC-----------NEWC---EKTRSVSCSHPYGIGCGSRKPKDVRKC----CHIKYTSD 1290
            ..|:|.||           ..||   |:...|..       |.|.||:.|:.|    |.......
Zfish  1195 KTGDWSECLVTCGKGYKHRQTWCQFGEERLDVRF-------CDSSKPESVQACQQQECASWQVGP 1252

  Fly  1291 WTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVY---VDESYCISRKVHRPKLRTTTKSCRIN 1352
            |..|:..||.|.:.:...|       |.|:     |   :|::.|  ....||   |.|:.|.::
Zfish  1253 WGQCTTTCGPGYQMRAVKC-------VVGS-----YGSVMDDTEC--NAATRP---TDTQDCGLS 1300

  Fly  1353 -C--------------------KWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKR 1396
             |                    :|....|.:|.|.|.:..:.|.|.|...||...|:..|....:
Zfish  1301 QCPVTHPVAPEPKVMPHPGHKTQWRFGSWTQCSATCGKGTRMRYVSCRDQQGGVAEESACAHLPK 1365

  Fly  1397 PSKRRICNNCVRRQSRVISQCNC-----EGVEKRRDFCFNSHKGRI------------------- 1437
            |....:|:.....|.:|:....|     :|...|:..|.|.....:                   
Zfish  1366 PPASEVCSIVACGQWKVLEWTACSVSCGQGTTTRQVVCMNISDQVVELSECDLDDKPAAEQECAM 1430

  Fly  1438 -ACPTRARVERHSCTPPPHCRRRSAIGSSISSRPRG--------TGVSSSRSLNSIGGSRNR--- 1490
             .||:|:. :....:|.|..|:::|:.........|        ||...:.|....||.:.|   
Zfish  1431 PQCPSRSS-DHGGFSPNPDFRKKTALPGRTDRNRAGRLQAQQWRTGPWGACSSTCAGGFQRRVVV 1494

  Fly  1491 -----GTPRSCAD 1498
                 |.|.|..|
Zfish  1495 CQDENGYPASSCD 1507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 28/108 (26%)
ZnMc_ADAMTS_like 455..655 CDD:239801 94/211 (45%)
Reprolysin 457..655 CDD:279729 94/209 (45%)
Salp15 <696..745 CDD:288931 18/48 (38%)
TSP1 754..806 CDD:214559 32/51 (63%)
ADAM_spacer1 937..1042 CDD:283607 37/111 (33%)
TSP1 1172..1229 CDD:214559 22/60 (37%)
GON 1495..1687 CDD:285848 2/4 (50%)
adamts9NP_001244125.1 Pep_M12B_propep 35..165 CDD:279848 14/75 (19%)
Pep_M12B_propep 217..347 CDD:279848 31/131 (24%)
Reprolysin 429..638 CDD:279729 96/217 (44%)
ZnMc_ADAMTS_like 429..635 CDD:239801 95/214 (44%)
TSP1 730..782 CDD:214559 32/51 (63%)
ADAM_spacer1 892..1010 CDD:283607 41/137 (30%)
TSP1 1140..1192 CDD:214559 22/59 (37%)
TSP1 1194..1245 CDD:214559 15/57 (26%)
TSP1 1248..1303 CDD:214559 16/71 (23%)
TSP1 1324..>1352 CDD:214559 8/27 (30%)
TSP1 1377..1434 CDD:214559 7/56 (13%)
TSP1 1472..1524 CDD:214559 10/36 (28%)
TSP1 1526..1580 CDD:214559
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 124 1.000 Domainoid score I5453
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 654 1.000 Inparanoid score I761
OMA 1 1.010 - - QHG48392
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 1 1.000 - - FOG0004456
OrthoInspector 1 1.000 - - otm24937
orthoMCL 1 0.900 - - OOG6_100241
Panther 1 1.100 - - O PTHR13723
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2551
SonicParanoid 1 1.000 - - X3160
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1212.010

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