DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and adamts13

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_002663267.4	Gene:	adamts13 / 100320289	ZFINID:	ZDB-GENE-070814-7	Length:	1498	Species:	Danio rerio

Alignment Length:	1144	Identity:	307/1144 - (26%)
Similarity:	475/1144 - (41%)	Gaps:	232/1144 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 HSMVSVSLC-GGMTGYIKTSFGALLIQPVNRTSSDEVLHRVFRKSQRNARHAVSKFELGLDDFM- 422
            |:...:.:| |.:.|.|::....|.|:||.....|            |.:........|:...:
Zfish   137 HTRTLLPVCYGKLQGLIQSGEMRLYIRPVLEQHID------------NLKDLTMDLPPGVPHLLI 189

  Fly   423 SKLEQVQEEEQKSKSR-KLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIV 486
            ::...|:...::.||: :|.|     :.:.::|..||:.:.|...:.:.|.:|.:.|||..::|.
Zfish   190 TQTLPVRTRLKQPKSQFRLRR-----SPLRSEVTYLELAVVVGPDVYEVHRQDTERYILTNLNIA 249

  Fly   487 SSIFADASIGNSIRILLVRLISL----PNINDQTHSSNEMLKHFCQF---INQSG----YERDTA 540
            |.:..|.::|.:||:.|||:|.|    |:|....:.::. ||..|::   :|...    ...|..
Zfish   250 SELLRDVTLGANIRVHLVRMIILTEPEPDIQISENITSS-LKSVCEWGQKVNPDADSDPLHADLL 313

  Fly   541 MLITREPICGSVPGKICHMLGLAELGTVCSSS-SCSIVQDTGLPTAFTMAHELGHILNMNHDD-D 603
            :.|||..:.  :|.....:.|:.:.|.|||:. :|.|.:|||.....|:|||:||...:|||. |
Zfish   314 LYITRFDLV--LPNGNKLVRGVTQFGGVCSTQWNCVITEDTGFDLGITIAHEIGHSFGINHDGID 376

  Fly   604 DKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLE--TSVGAHIPYG 666
            :.|         :....:|:|..|.:....:||:|||..:..|.......|::  ..:|..:
Zfish   377 NTC---------SSSGFMMASDGGYNSVDLTWSQCSRAQLYSFFRAGKAECVQDVPVLGGSV--- 429

  Fly   667 TERLPGEIYSLDAQCQLSFGNDFGYCP-TDEE---CKRLWCNRTSGNSNEQCASSNLPWADGTPC 727
            .:..||..|.:|.||:::||:....|. |:|:   |:.|.|: .:...:..|....:|..|||.|
Zfish   430 QDWRPGLFYGVDDQCRIAFGSSATACSFTNEDMTTCRVLSCH-INPQDHSSCTRLLVPLLDGTEC 493

  Fly   728 GSSGHWCQRGKCVS-NKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCT 791
            |.| .||.:|:||| :..|....|:|.|..|:.|:|||.|||||:...||:||.|....||..|.
Zfish   494 GPS-QWCLKGRCVSPSTSGSSMMVHGSWSAWSDFSPCSRTCGGGITHRRRQCNNPRSAFGGTICK 557

  Fly   792 GSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTK----WVPKYEKDA----CKLF 848
            |...:...||...|....::...:||.|.:.:.::   |:.|:|    |:|.....:    |||.
Zfish   558 GQNTEAELCNLQLCDSTQLEFMARQCSATDQQPLS---VSTDSKSMYTWIPAISYSSGDSQCKLM 619

  Fly   849 CRMDMKVTYFMLK--SMVTDGTSCAVD------SFDKCVNGICRPAGCDNELNSIAKLDKCGVCE 905
            ||  .:...||:.  |...|||.|..|      |...|::|.|:..|||..|:|....|.||||.
Zfish   620 CR--SREQDFMVSRGSQFIDGTRCESDNPVPHGSISACLSGKCQLFGCDGALHSGKVEDVCGVCG 682

  Fly   906 GRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVT--RIPKGASNIIITQRGYPDQNFIVLTDDR 968
            |...|||      |:||........|      |||  .:|..||.:.:........:..||.:|:
Zfish   683 GNGSTCH------LISNTYSGGKAGE------YVTFLTLPLNASQVHVFNTRSIFTHLAVLLNDK 735

  Fly   969 DNELLNGK--FLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQ 1031
            .....|||  ...|||                |.:|:...||...|:.|.:.|...|.:|.....
Zfish   736 YVVSGNGKPGLSNTYP----------------SPLEKSLITYKLYLTPDHLPQTEELYISGPVTD 784

  Fly  1032 DTVL-----------------LSYSYTIDKPPDYEAEVEIY---RWEMQAPSNCDSLCEGRSHRL 1076
            ...|                 :||.|..|     :..|||.   :|               |..:
Zfish   785 KIHLQVYRKYGQEYGDLTNPNISYQYYSD-----DVIVEIASKGKW---------------STTI 829

  Fly  1077 PAC-ISTTQGVKVAPQFC-DKSAMPKIDDRACNT--------------DCRLNLTVTSISECSAA 1125
            .|| ::..:|::...|.| |...:..:.|..|::              ||.....|:...|||..
Zfish   830 SACSVTCGRGIQKIYQHCVDLVTLEHLKDELCSSLPRSSDLLQPCFLPDCPPRWQVSEPGECSTV 894

  Fly  1126 CGELGTREKTYACVQTFTNMQRSN-----------------IVDMSYCKLKFDV---------AY 1164
            ||. |..::...||: |.|.....                 :||:  |.||:|.         |.
Zfish   895 CGP-GEAQRKVFCVR-FHNKSYLEVDQNLCSQPKPPEYVPCVVDV--CPLKWDTENETQLIHRAS 955

  Fly  1165 HEECREGCWVLSEWS----TCSKSCGTGSQQREAHCYLHNSR--VSDDLCNPRTKPHLNT---LI 1220
            |...|.....:..||    .|||:||.||||.:..|..|.||  |.:.||:|.|||..:|   .|
Zfish   956 HGMVRSKIVPVYVWSPRTGECSKTCGNGSQQVQFSCVDHKSRLEVPETLCDPTTKPAQDTQPCRI 1020

  Fly  1221 GICNTESCP--TYTKSPNALAVSNWVIGEWGECNEWCEKTRSVSCSHPYGIG---CGS-RKPKDV 1279
            .:|    .|  .|.:.|.:::....:......|::..|:...   ::...:|   |.| .||.:|
Zfish  1021 SLC----LPIWRYIQGPCSVSCGGGIAKRVLFCSQRMEENDG---NNDLVVGETACDSVPKPPEV 1078

  Fly  1280 RKC----CHIKY-TSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHR 1339
            .:|    |..:: ..|..||||.||.||..:...|.: |:..|...      |:|..|.|.....
Zfish  1079 VECNTEKCKARWQVGDQGDCSVTCGMGVALRSVQCVQ-YEGGVERD------VEEEKCESETKPP 1136

  Fly  1340 PKLRTTTKSCRINCKWNASDWRRCPADCSEEYQTRDVRC 1378
            ..:...|:.|..|  |:..||.:|...|....|:|.|.|
Zfish  1137 VTVPCFTQVCSFN--WDVHDWSKCSVSCGYGIQSRAVSC 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	9/34 (26%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	60/212 (28%)
		Reprolysin	457..655	CDD:279729	60/210 (29%)
		Salp15	<696..745	CDD:288931	18/52 (35%)
		TSP1	754..806	CDD:214559	22/51 (43%)
		ADAM_spacer1	937..1042	CDD:283607	28/125 (22%)
		TSP1	1172..1229	CDD:214559	25/65 (38%)
		GON	1495..1687	CDD:285848
adamts13	XP_002663267.4	Reprolysin	219..423	CDD:279729	61/215 (28%)
		ZnMc_ADAMTS_like	219..420	CDD:239801	61/212 (29%)
		TSP1	520..572	CDD:214559	22/51 (43%)
		TSP1	966..1023	CDD:214559	24/56 (43%)
		TSP1	1154..1205	CDD:214559	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920