DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AdamTS-A and adamts12

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:XP_021332071.1 Gene:adamts12 / 100003937 ZFINID:ZDB-GENE-070705-471 Length:1500 Species:Danio rerio


Alignment Length:1525 Identity:396/1525 - (25%)
Similarity:582/1525 - (38%) Gaps:430/1525 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   223 EPPDGLDDLDEE----EHSAFVM--PTKV------YNYSLSEADLIYESKRNSDINSFLKESASA 275
            ||.....|.::|    :||.|.:  |.||      .:|:||........||  |:||        
Zfish    27 EPDYLFPDTEQEHFVKQHSEFYVDHPEKVNGEGKFISYALSHHFTRRRQKR--DLNS-------- 81

  Fly   276 FAMTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEA 340
             |....|             |.||..||:|.|.|..:.:.:.|..:.        |:..|...|.
Zfish    82 -AERRVY-------------YKLNYRGRELTLNLTTNDNLLSNEFIV--------EKRNGSLAEK 124

  Fly   341 EAEQRHLG-CFYSGYVEDD-PHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSD----EVLHRV 399
            ..:....| |...|.|.|| ..:..::|.|.|:.|.:....|.|||:||...|.:    :..|.:
Zfish   125 WPQSSDSGSCHLIGTVTDDNVQATAAISTCEGLRGLLNLPEGPLLIEPVRGRSPNLTHPQHPHVL 189

  Fly   400 FRKS------QRNARHAVSKFELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYT-- 456
            ::.|      ||.:..|..:...|:.|.....:||:::.:..:...::|..|...:...::..  
Zfish   190 YQSSTWSRFRQRRSIDAHQQSPCGVKDSSGYFQQVEQDRELWERESVDRNHRPDPERPRRISPRS 254

  Fly   457 ------LEVLIAVDNSMKQFHGE-DLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNIND 514
                  :|.::..|:.:..:||. .::.||..:|::|:.||.||||||:|.|:|||||.|.....
Zfish   255 ISRERWVETMVVGDSKLVDYHGSGSVESYIFTIMNMVAGIFHDASIGNAIHIVLVRLILLHGEEK 319

  Fly   515 Q---THSSNEMLKHFCQFINQSGYERDT-------AMLITREPICGSVPGKICHMLGLAELGTVC 569
            .   .|.::..|..||.:......:.||       |:||||:.:|..: .:.|..|||:.|..:|
Zfish   320 GLKIIHHADTTLTSFCTWQKNLNPQSDTHPAHHDVAILITRKDVCAGM-NQPCETLGLSHLSGMC 383

  Fly   570 S-SSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPW 633
            . ..||:|.:|:|||.|||:||||||...:.||.......:|.:|.     .|||..:.....|.
Zfish   384 QPHRSCNINEDSGLPVAFTIAHELGHSFGIQHDGQGNDCEFVGKQP-----FIMSRQLQYDSSPL 443

  Fly   634 SWSKCSRHFVSEFLEKTDKSCLE--------TSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFG 690
            :||.||:.:::.||::....||:        ::.||        .||..|:...||||.:|.:..
Zfish   444 TWSSCSKEYITRFLDRGWGFCLDDRPSKRDLSTPGA--------APGVRYTPQHQCQLQYGPNAT 500

  Fly   691 YCPTDEE-CKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGR---QVN 751
            :|...|. |:.|||     :.|..|.|......|||.||.. .||..|:||.    .|:   .|:
Zfish   501 FCSEVENVCQILWC-----SVNGSCRSKLDSPIDGTRCGPE-KWCISGECVI----VGKLPETVH 555

  Fly   752 GGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQ 816
            ||||||:.::.||.|||.|||.:.||||||.||.|||||||.||:||.|||..|.......||.|
Zfish   556 GGWGPWSSWSHCSRTCGAGVQTADRECNQPKPEFGGKYCTGERKRYRVCNTKLCVRKHPSFREMQ 620

  Fly   817 CYAMNGRNMNIPGVNPDTKWVP-KYEKDACKLFCR-MDMKVTYFMLKSMVTDGTSCAVDSFDK-- 877
            |...|    .:|..|...:|:| ......|:|.|: :|...:..||.: |||||.|.:::..:  
Zfish   621 CSEFN----TVPYHNELYQWIPVSSPSRPCELHCKPVDENFSEKMLDA-VTDGTPCFMNNNSRNI 680

  Fly   878 CVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRI 942
            ||||:|:..|||..:||.||.|.||||.|...||..|..|.:..:..|..|          :..|
Zfish   681 CVNGVCKEVGCDFGINSNAKEDSCGVCLGDGSTCETVKENFVEQDGFGYMD----------LVLI 735

  Fly   943 PKGASNIIITQRGYPDQNFIVL-TDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNT 1006
            |.||.:|.| |......||:.: ..|.|...|||.::..:..::...|....|..|.::   .|.
Zfish   736 PAGARDIYI-QEVEEAGNFLAMRASDSDEYYLNGNYIIQWNGEYEAGGTKFNYERSGNI---ENL 796

  Fly  1007 TYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTID--KPPDYEAEVEIYRWEMQAPSNCDSLC 1069
            |.:...:..:::|::..:::|.       :.|.|||.  :|...|.....|.|:..|.::|.:.|
Zfish   797 TSAGPTTEPVMIQLLFQELNPG-------VKYEYTIKRRRPLGNEILEPEYIWKHGAWTDCSTTC 854

  Fly  1070 E-GRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNT-DCRLNLTVTSISECSAACGELGTR 1132
            . |..|:...|.....|| |....||.|..|....|.|.: ||.....|.....||:.||..|.:
Zfish   855 GLGEQHQPVRCFEPEVGV-VEENLCDPSTRPDDKHRKCKSRDCPARWWVGGWQTCSSTCGSTGVK 918

  Fly  1133 EKTYACVQTFTNMQRSNIVDMSYCK--LK--------FDVAYHEECREGCWVLSEWSTCSKSCGT 1187
            ::|..||:|....:|  ::....||  ||        .||....|     |.:..||.||:||..
Zfish   919 KRTILCVRTVAGEER--VLHPGDCKQLLKPKPAVPCNRDVPCGSE-----WTVGNWSECSQSCDG 976

  Fly  1188 GSQQREAHCYLHN-SRVSDDLCNPRTKPHLNTLIGICNTESC----------------------- 1228
            |.:.|...|.... ||     |||.|:|....|   ||.:||                       
Zfish   977 GIKSRMVKCVAKQPSR-----CNPATRPRSTIL---CNLQSCSSTNRWTGPRFRPRKIPTQPPGT 1033

  Fly  1229 ------------------------------------------------PT--------------- 1230
                                                            ||               
Zfish  1034 QTTQYSPTITPPNTSTPITTQSNTSPTSDIIHEDDKDFILVKKNNVAVPTITEDEEGSTDLQPPD 1098

  Fly  1231 ---------------------YTKSPNALAVSN-------------------------------- 1242
                                 :|..|..:.:|:                                
Zfish  1099 KSYTPGYDYIEDPERIREDDLFTSKPEEVLISSVQPITMSAPVSTTKPAITTTIRTQYDGHLATH 1163

  Fly  1243 ----------------------------------------------------------------- 1242
                                                                             
Zfish  1164 ACAKTSLYEFNSTPKPTLSHLNTLSSQVTVPTVKILRKALQTLKVPNKSNVLKAARLKLQMTTIT 1228

  Fly  1243 -----------------WVIGEWGECNEWC---EKTRSVSCSHPYGIGCGS-RKPKDVRKC---- 1282
                             |.:|.|.:|:..|   ...||||||......|.| :||:..|:|    
Zfish  1229 DDDDGNLNAQIVSKNAFWKVGNWSDCSTSCGLGAVWRSVSCSSKQEEDCASVKKPEPARRCNLRP 1293

  Fly  1283 CHIKYTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRP--KLRTT 1345
            |.:..|.:|:.|...|...:|.::..|.     |....|..|.:    :|.:.. |:|  .|...
Zfish  1294 CAVWKTGNWSKCPEGCVTDMKYREVQCI-----DTQNRRPLRPF----HCQALS-HKPPSSLPCN 1348

  Fly  1346 TKSCRINCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICN--NCVR 1408
            |..|   .:|..|.|..|...|....:.|.|.|.       |::||:...:|:....|:  .|..
Zfish  1349 TLPC---LQWMHSPWGECSKSCGHGVKERLVYCP-------ENQHCNVTLKPNSTESCHLQPCAG 1403

  Fly  1409 RQSRVISQC--NC-EGVEKRRDFCFNSHKG 1435
            ..:...|||  :| .||:||...|.|...|
Zfish  1404 WATEAWSQCSRSCGGGVQKRAVRCINEESG 1433

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 29/113 (26%)
ZnMc_ADAMTS_like 455..655 CDD:239801 72/219 (33%)
Reprolysin 457..655 CDD:279729 72/209 (34%)
Salp15 <696..745 CDD:288931 18/49 (37%)
TSP1 754..806 CDD:214559 34/51 (67%)
ADAM_spacer1 937..1042 CDD:283607 23/105 (22%)
TSP1 1172..1229 CDD:214559 22/128 (17%)
GON 1495..1687 CDD:285848
adamts12XP_021332071.1 Pep_M12B_propep 51..190 CDD:307618 43/170 (25%)
ZnMc_ADAMTS_like 259..466 CDD:239801 73/212 (34%)
ADAM_CR 529..689 CDD:326582 75/169 (44%)
TSP1 558..609 CDD:214559 34/50 (68%)
ADAM_spacer1 715..825 CDD:310520 27/130 (21%)
TSP1 960..1011 CDD:214559 22/63 (35%)
TSP_1 1358..1401 CDD:326556 12/49 (24%)
TSP1 1404..1458 CDD:214559 11/30 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 83 1.000 Domainoid score I8312
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100241
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.720

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