DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and LOC100001991

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_001341878.1	Gene:	LOC100001991 / 100001991	-ID:	-	Length:	927	Species:	Danio rerio

Alignment Length:	1098	Identity:	330/1098 - (30%)
Similarity:	486/1098 - (44%)	Gaps:	269/1098 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 FLKESASAF--------AMTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHI 324
            |.:.||..|        .:||.......:..:..|.:.|:.|||...|.|..|::|: :.::...
Zfish    12 FAETSARLFETEEIVPVQLTGRSGGRVAKRSETQPSFRLSAFGRNFTLNLTPDSTFI-SPALKVY 75

  Fly   325 RILKEGEEHPGP----------ETEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSF 379
            |:..:.:|....          :||....:...||||:|:|:....|:||||||.|:.|...:..
Zfish    76 RVKVKPQEKSTSNLTDLYQSLNQTEETGTEFLKGCFYTGFVDSSEDSVVSVSLCRGILGSFISDG 140

  Fly   380 GALLIQPVN-----RTSSDEVLH----RVFRKSQRNARHAVSKFELGLDDFMSKLEQVQEEEQKS 435
            ...||:|.:     :....|.||    |.|.||.:     |||          :|..::.:.|.|
Zfish   141 KEYLIEPKSFGLGTKGKLTEQLHVIKRRRFAKSSQ-----VSK----------QLSDMRADLQNS 190

  Fly   436 KSRKLNRKKRHYADVDNQVYT---LEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGN 497
            :.:..:|::|.       |.|   :|.|:..|.|:..|:|::::.|:|.|||:.:.::...||.|
Zfish   191 RIQMPSRRRRF-------VSTPRFIETLVVGDASLTHFYGDEIKHYMLTLMSVAAQVYKHPSIKN 248

  Fly   498 SIRILLVRLISL------PNINDQTHSSN--EMLKHFC---QFINQSGYER----DTAMLITREP 547
            ||.|:||:::.:      |:|     |||  ..|:.||   |..|.|.:..    |||:|.|||.
Zfish   249 SINIVLVKMLIVEDEEVGPSI-----SSNGGVALRSFCAWQQLFNPSSHRHPEHYDTAILFTRED 308

  Fly   548 ICGSVPGKICHMLGLAELGTVCSSS-SCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVT 611
            |||.   :.|..||:|::||:|.:. |||:::|.||..|:|.||||||:|:|.|||...|.....
Zfish   309 ICGH---QSCETLGVADVGTMCDTKRSCSVIEDNGLQAAYTTAHELGHVLSMPHDDTKSCEQLFG 370

  Fly   612 RQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL----ETSVGAHIPYGTERLPG 672
            ....:   |||:.|.........||.||..:|:||.:.....||    ||:|.  :|  || |||
Zfish   371 HLGED---HIMAPVFTQLSKTSPWSPCSALYVTEFFDNGHGDCLLDAPETTVA--LP--TE-LPG 427

  Fly   673 EIYSLDAQCQLSFGNDFGYCP---TDEECKRLWCNRTSGNSNEQCASSN--LPWADGTPCGSSGH 732
            ..||||.|||..||.:|.:||   :.|.|:||||.: .|.|  .|.:.|  |||||||.||:: .
Zfish   428 LTYSLDRQCQQIFGEEFSHCPNTSSSEVCERLWCQQ-EGQS--MCTTRNGSLPWADGTSCGTN-R 488

  Fly   733 WCQRGKCVSNKHGYGRQ--VNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRK 795
            .|....|:|::.....|  |:||||.|..:.|||.:|||||..|.||||:|.|:||||||.|.|.
Zfish   489 TCLNSVCMSSEDVLRPQPAVDGGWGEWGSWQPCSRSCGGGVMFSYRECNRPSPQNGGKYCVGQRV 553

  Fly   796 KYRSCNTHQCPPG-SMDPREQQCYAMNGRNMNIPGVNPDTK-WVPKYE----KDACKLFCRMDMK 854
            .|:|||...|... ....||:||...|  |.|...::.:.| |:|||.    :|.||||||....
Zfish   554 NYQSCNKQACENNRGKSFREEQCEKYN--NPNHFDIHGNVKQWIPKYAGVSLRDRCKLFCRARGS 616

  Fly   855 VTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLL 919
            ..:.:....|.|||.|..|:...||.|.|..||||.|::|..|||||.||.|...:|..::|:.
Zfish   617 SEFRVFAPKVIDGTPCGPDTTSFCVQGQCIKAGCDLEIDSSKKLDKCAVCGGNGQSCRIISGSF- 680

  Fly   920 VSNLLGLNDGNEPNKTLY-Y--VTRIPKGASNIIITQRGY----PDQNFIVLTDDRDNELLNGKF 977
                         ||.:: |  :..||.||:||.|.|:.:    .|.:::.:..:..|.:|||.|
Zfish   681 -------------NKVVHGYRDIVTIPSGATNINIKQQSHGSIPHDGHYLAVRRENGNYILNGNF 732

  Fly   978 -LKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIIS--LDVSPSKRQDTVLLSYS 1039
             :.|........|..::|:|||:.:|::.:..  :|...:.:|::|  .:..|.|.:.|..:..|
Zfish   733 SVSTVEQHIPVLGAVLKYSGSSTTLERLQSFR--QLQEPITIQLLSTAAESIPPKVKYTFYIPKS 795

  Fly  1040 YTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDR 1104
            ....||.|                                      .|:|.:......:|:
Zfish   796 MAFSKPKD--------------------------------------KKIAGKLIHPFGVPQ---- 818

  Fly  1105 ACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECR 1169

Zfish   819 ----------------------------------------------------------------- 818

  Fly  1170 EGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKS 1234
               |:.||||.|||:||:|..:|...| ..|:....:.||...:|   :.|..|....||.
Zfish   819 ---WISSEWSECSKTCGSGWSRRNVEC-KDNAGFYSNHCNKDLRP---SDIRPCADLPCPI---- 872

  Fly  1235 PNALAVSNWVIGEWGECNEWC---EKTRSVSCSHPYG-----IGCGSRK-PKDVRKCC 1283
                    |.||.|..|::.|   |:.|.:.|....|     ..|...| |:.|.:.|
Zfish   873 --------WQIGPWSSCSQTCGHGERQRKILCIDYTGKTVEPENCDPAKMPESVSEKC 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	31/122 (25%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	79/218 (36%)
		Reprolysin	457..655	CDD:279729	78/213 (37%)
		Salp15	<696..745	CDD:288931	22/50 (44%)
		TSP1	754..806	CDD:214559	30/51 (59%)
		ADAM_spacer1	937..1042	CDD:283607	29/114 (25%)
		TSP1	1172..1229	CDD:214559	19/56 (34%)
		GON	1495..1687	CDD:285848
LOC100001991	XP_001341878.1	Pep_M12B_propep	40..165	CDD:279848	34/125 (27%)
		Reprolysin	206..415	CDD:279729	80/219 (37%)
		ZnMc_ADAMTS_like	206..412	CDD:239801	79/216 (37%)
		ADAM_CR	425..495	CDD:301627	35/73 (48%)
		TSP1	512..564	CDD:214559	30/51 (59%)
		ADAM_spacer1	674..793	CDD:283607	31/134 (23%)
		TSP1	822..871	CDD:214559	18/52 (35%)
		TSP1	873..915	CDD:214559	12/41 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10808
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24937
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820