Protein Alignment AdamTS-A and LOC100001991

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: XP_001341878.1
• Gene: LOC100001991 / 100001991
• -ID: -
• Length: 927
• Species: Danio rerio
• Alignment Length: 1098
• Identity: 330/1098 - (30%)
• Similarity: 486/1098 - (44%)
• Gaps: 269/1098 - (24%)

  Fly   268 FLKESASAF--------AMTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHI 324
            |.:.||..|        .:||.......:..:..|.:.|:.|||...|.|..|::|: :.::...
Zfish    12 FAETSARLFETEEIVPVQLTGRSGGRVAKRSETQPSFRLSAFGRNFTLNLTPDSTFI-SPALKVY 75

  Fly   325 RILKEGEEHPGP----------ETEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSF 379
            |:..:.:|....          :||....:...||||:|:|:....|:||||||.|:.|...:..
Zfish    76 RVKVKPQEKSTSNLTDLYQSLNQTEETGTEFLKGCFYTGFVDSSEDSVVSVSLCRGILGSFISDG 140

  Fly   380 GALLIQPVN-----RTSSDEVLH----RVFRKSQRNARHAVSKFELGLDDFMSKLEQVQEEEQKS 435
            ...||:|.:     :....|.||    |.|.||.:     |||          :|..::.:.|.|
Zfish   141 KEYLIEPKSFGLGTKGKLTEQLHVIKRRRFAKSSQ-----VSK----------QLSDMRADLQNS 190

  Fly   436 KSRKLNRKKRHYADVDNQVYT---LEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGN 497
            :.:..:|::|.       |.|   :|.|:..|.|:..|:|::::.|:|.|||:.:.::...||.|
Zfish   191 RIQMPSRRRRF-------VSTPRFIETLVVGDASLTHFYGDEIKHYMLTLMSVAAQVYKHPSIKN 248

  Fly   498 SIRILLVRLISL------PNINDQTHSSN--EMLKHFC---QFINQSGYER----DTAMLITREP 547
            ||.|:||:::.:      |:|     |||  ..|:.||   |..|.|.:..    |||:|.|||.
Zfish   249 SINIVLVKMLIVEDEEVGPSI-----SSNGGVALRSFCAWQQLFNPSSHRHPEHYDTAILFTRED 308

  Fly   548 ICGSVPGKICHMLGLAELGTVCSSS-SCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVT 611
            |||.   :.|..||:|::||:|.:. |||:::|.||..|:|.||||||:|:|.|||...|.....
Zfish   309 ICGH---QSCETLGVADVGTMCDTKRSCSVIEDNGLQAAYTTAHELGHVLSMPHDDTKSCEQLFG 370

  Fly   612 RQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL----ETSVGAHIPYGTERLPG 672
            ....:   |||:.|.........||.||..:|:||.:.....||    ||:|.  :|  || |||
Zfish   371 HLGED---HIMAPVFTQLSKTSPWSPCSALYVTEFFDNGHGDCLLDAPETTVA--LP--TE-LPG 427

  Fly   673 EIYSLDAQCQLSFGNDFGYCP---TDEECKRLWCNRTSGNSNEQCASSN--LPWADGTPCGSSGH 732
            ..||||.|||..||.:|.:||   :.|.|:||||.: .|.|  .|.:.|  |||||||.||:: .
Zfish   428 LTYSLDRQCQQIFGEEFSHCPNTSSSEVCERLWCQQ-EGQS--MCTTRNGSLPWADGTSCGTN-R 488

  Fly   733 WCQRGKCVSNKHGYGRQ--VNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRK 795
            .|....|:|::.....|  |:||||.|..:.|||.:|||||..|.||||:|.|:||||||.|.|.
Zfish   489 TCLNSVCMSSEDVLRPQPAVDGGWGEWGSWQPCSRSCGGGVMFSYRECNRPSPQNGGKYCVGQRV 553

  Fly   796 KYRSCNTHQCPPG-SMDPREQQCYAMNGRNMNIPGVNPDTK-WVPKYE----KDACKLFCRMDMK 854
            .|:|||...|... ....||:||...|  |.|...::.:.| |:|||.    :|.||||||....
Zfish   554 NYQSCNKQACENNRGKSFREEQCEKYN--NPNHFDIHGNVKQWIPKYAGVSLRDRCKLFCRARGS 616

  Fly   855 VTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLL 919
            ..:.:....|.|||.|..|:...||.|.|..||||.|::|..|||||.||.|...:|..::|:.
Zfish   617 SEFRVFAPKVIDGTPCGPDTTSFCVQGQCIKAGCDLEIDSSKKLDKCAVCGGNGQSCRIISGSF- 680

  Fly   920 VSNLLGLNDGNEPNKTLY-Y--VTRIPKGASNIIITQRGY----PDQNFIVLTDDRDNELLNGKF 977
                         ||.:: |  :..||.||:||.|.|:.:    .|.:::.:..:..|.:|||.|
Zfish   681 -------------NKVVHGYRDIVTIPSGATNINIKQQSHGSIPHDGHYLAVRRENGNYILNGNF 732

  Fly   978 -LKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIIS--LDVSPSKRQDTVLLSYS 1039
             :.|........|..::|:|||:.:|::.:..  :|...:.:|::|  .:..|.|.:.|..:..|
Zfish   733 SVSTVEQHIPVLGAVLKYSGSSTTLERLQSFR--QLQEPITIQLLSTAAESIPPKVKYTFYIPKS 795

  Fly  1040 YTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDR 1104
            ....||.|                                      .|:|.:......:|:
Zfish   796 MAFSKPKD--------------------------------------KKIAGKLIHPFGVPQ---- 818

  Fly  1105 ACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECR 1169
                                                                             
Zfish   819 ----------------------------------------------------------------- 818

  Fly  1170 EGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKS 1234
               |:.||||.|||:||:|..:|...| ..|:....:.||...:|   :.|..|....||.
Zfish   819 ---WISSEWSECSKTCGSGWSRRNVEC-KDNAGFYSNHCNKDLRP---SDIRPCADLPCPI---- 872

  Fly  1235 PNALAVSNWVIGEWGECNEWC---EKTRSVSCSHPYG-----IGCGSRK-PKDVRKCC 1283
                    |.||.|..|::.|   |:.|.:.|....|     ..|...| |:.|.:.|
Zfish   873 --------WQIGPWSSCSQTCGHGERQRKILCIDYTGKTVEPENCDPAKMPESVSEKC 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	30/113 (27%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	79/218 (36%)
		ADAMTS_CR_2	671..740	CDD:465496	34/73 (47%)
		TSP1	754..806	CDD:214559	30/51 (59%)
		ADAMTS_CR_3	815..911	CDD:437068	41/100 (41%)
		TSP1	1172..1229	CDD:214559	19/56 (34%)
		TSP1_ADAMTS	1243..1282	CDD:465950	14/47 (30%)
		TSP1_ADAMTS	1355..1405	CDD:465950
		GON	1493..1687	CDD:462559
LOC100001991	XP_001341878.1	Pep_M12B_propep	24..147	CDD:460254	32/123 (26%)
		ZnMc_ADAMTS_like	206..412	CDD:239801	79/216 (37%)
		ADAMTS_CR_2	426..495	CDD:465496	34/72 (47%)
		TSP1	512..564	CDD:214559	30/51 (59%)
		ADAMTS_CR_3	<595..673	CDD:437068	34/77 (44%)
		ADAMTS_spacer1	675..793	CDD:461796	31/133 (23%)
		TSP1_ADAMTS	819..870	CDD:465950	19/54 (35%)
		TSP1_ADAMTS	873..927	CDD:465950	15/50 (30%)