DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Act88F and Actl9b

DIOPT Version :9

Sequence 1:	NP_524367.1	Gene:	Act88F / 41885	FlyBaseID:	FBgn0000047	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001013915.1	Gene:	Actl9b / 292516	RGDID:	1359476	Length:	411	Species:	Rattus norvegicus

Alignment Length:	371	Identity:	156/371 - (42%)
Similarity:	233/371 - (62%)	Gaps:	11/371 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LVIDNGSGMCKAGFAGDDAPRAVFPSIVG-RPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPI 72
            :|||.|:|:||.||||...|..:..:||| :|:.:..| ...:.:.::| ||...|..|||.:|:
  Rat    47 VVIDMGTGICKMGFAGQTRPTYIVRNIVGCQPKRRTTM-EQPKMEMFIG-EAAHARPELTLMHPV 109

  Fly    73 EHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAI 137
            .:||:.:|:..|.||.|...|:||:..::||:|.|:.|.||.:||||:.::.||:.:|||:|||.
  Rat   110 RNGIVVDWEAAEFIWRHILENDLRLDTQDHPLLFTDPPFNPASNREKLVEVAFESLHSPAIYVAS 174

  Fly   138 QAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGFALPHAILRLDLAGRDLTDYLM-KILTERGYSF 201
            |:|||:||:||..|:|:|:|.|||:|||:::|:.||..|.|:||||..||.:|. |||..   ||
  Rat   175 QSVLSVYANGRVNGLVVDTGHGVSYTVPVFQGYNLPSGIQRMDLAGHYLTKFLAEKILRS---SF 236

  Fly   202 TTTAE-REIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPEALFQ- 264
            ....| .:.:.:||::.|||||||::|.  ........:..:|||||:||:|.|.|:|||.||.
  Rat   237 AVKKEDMDTMENIKQQYCYVALDFQKEQ--GRPDEKFRRCLKLPDGQMITVGKELFQCPELLFHP 299

  Fly   265 PSFLGMESCGIHETVYNSIMKCDVDIRKDLYANSVLSGGTTMYPGIADRMQKEITALAPSTIKIK 329
            |...|..|.|:...|.:|:.....::|.|:..|.:|.||::::.|...|.:.|:.........:.
  Rat   300 PDTSGPSSLGLPSMVEHSLSTVPQELRADMEQNVLLCGGSSLFTGFEGRFKTELLRRLGPEAHVV 364

  Fly   330 IIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKC 375
            ::|...|..||||||||||||..||..|:.:::|:|.||.||.|||
  Rat   365 VVAQANRNLSVWIGGSILASLCAFQTRWVLREQYEEHGPDIVLRKC 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act88F	NP_524367.1	PTZ00281	1..376	CDD:173506	156/371 (42%)
Actl9b	NP_001013915.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		NBD_sugar-kinase_HSP70_actin	45..410	CDD:302596	154/369 (42%)
		Actin	47..411	CDD:278451	156/371 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010