DRSC/TRiP Functional Genomics Resources

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Protein Alignment Act88F and POTEB3

DIOPT Version :9

Sequence 1:NP_524367.1 Gene:Act88F / 41885 FlyBaseID:FBgn0000047 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_997238.2 Gene:POTEB3 / 102724631 HGNCID:51240 Length:581 Species:Homo sapiens


Alignment Length:281 Identity:55/281 - (19%)
Similarity:95/281 - (33%) Gaps:86/281 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 GSGMCKAGFAG--DDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGIL-TLK------ 69
            |||....|.:|  ||:......|.:|:..|.......|...|.||.........: ||:      
Human    37 GSGKSNMGTSGDHDDSFMKTLRSKMGKCCHHCFPCCRGSGTSNVGTSGDHDNSFMKTLRSKMGKW 101

  Fly    70 ----YPIEHGI----ITNW-----------------DDMEKIWHHTFYNELRVAPEEHPVLLTEA 109
                :|...|.    :..|                 :|::|:....::.  :|..::..|:|.:.
Human   102 CCHCFPCCRGSGKSNVGTWGDYDDSAFMEPRYHVRREDLDKLHRAAWWG--KVPRKDLIVMLRDT 164

  Fly   110 PLNPKANREKMTQIMFETFNS-----------------------PAMYVAIQ-----AVLSLYAS 146
            .:| |.:::|.|.:...:.|.                       .|:..|:|     .||.|...
Human   165 DMN-KRDKQKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEH 228

  Fly   147 GRTTGIVLDSGDGVSHTVPIYEGFALPHAILRLDLAGRD--------LTDYLMKILTERGYSFTT 203
            |....|..:.|:...|.....|...:..|:|   |.|.|        ||..|:.:..::      
Human   229 GADGNIQDEYGNTALHYAIYNEDKLMAKALL---LYGADIESKNKCGLTPLLLGVHEQK------ 284

  Fly   204 TAEREIVRD-IKEKLCYVALD 223
               :::|:. ||:|....|||
Human   285 ---QQVVKFLIKKKANLNALD 302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Act88FNP_524367.1 PTZ00281 1..376 CDD:173506 55/281 (20%)
POTEB3NP_997238.2 Ank_4 143..193 CDD:290365 8/52 (15%)
ANK 167..292 CDD:238125 25/137 (18%)
ANK 1. /evidence=ECO:0000255 172..201 3/28 (11%)
ANK repeat 174..203 CDD:293786 2/28 (7%)
Ank_2 177..269 CDD:289560 17/94 (18%)
ANK repeat 205..236 CDD:293786 8/30 (27%)
ANK 2. /evidence=ECO:0000255 205..234 7/28 (25%)
ANK 233..357 CDD:238125 19/82 (23%)
ANK repeat 238..269 CDD:293786 8/33 (24%)
ANK 3. /evidence=ECO:0000255 238..267 8/31 (26%)
Ank_2 243..335 CDD:289560 17/72 (24%)
ANK repeat 271..302 CDD:293786 8/39 (21%)
ANK 4. /evidence=ECO:0000255 271..300 7/37 (19%)
ANK repeat 304..335 CDD:293786
ANK 5. /evidence=ECO:0000255 304..333
ANK 6. /evidence=ECO:0000255 337..366
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..494
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100127
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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