DRSC/TRiP Functional Genomics Resources

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Protein Alignment Act88F and POTEB

DIOPT Version :9

Sequence 1:NP_524367.1 Gene:Act88F / 41885 FlyBaseID:FBgn0000047 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_001264233.1 Gene:POTEB / 100996331 HGNCID:33734 Length:544 Species:Homo sapiens


Alignment Length:255 Identity:53/255 - (20%)
Similarity:94/255 - (36%) Gaps:71/255 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 GSGMCKAGFAG--DDAPRAVFPSIVGR------PRHQGVMVGMGQKDSYVGDEAQSKRGILTLKY 70
            |||....|.:|  ||:......|.:|:      |..:|  .|.....:: ||...|  ..:..:|
Human    37 GSGTSNVGTSGDHDDSFMKTLRSKMGKWCCHCFPCCRG--SGKSNVGTW-GDYDDS--AFMEPRY 96

  Fly    71 PIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNS----- 130
            .:..      :|::|:....::.  :|..::..|:|.:..:| |.:::|.|.:...:.|.     
Human    97 HVRR------EDLDKLHRAAWWG--KVPRKDLIVMLRDTDMN-KRDKQKRTALHLASANGNSEVV 152

  Fly   131 ------------------PAMYVAIQ-----AVLSLYASGRTTGIVLDSGDGVSHTVPIYEGFAL 172
                              .|:..|:|     .||.|...|....|..:.|:...|.....|...:
Human   153 QLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTALHYAIYNEDKLM 217

  Fly   173 PHAILRLDLAGRD--------LTDYLMKILTERGYSFTTTAEREIVRD-IKEKLCYVALD 223
            ..|:|   |.|.|        ||..|:.:..::         :|:|:. ||:|....|||
Human   218 AKALL---LYGADIESKNKCGLTPLLLGVHEQK---------QEVVKFLIKKKANLNALD 265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Act88FNP_524367.1 PTZ00281 1..376 CDD:173506 53/255 (21%)
POTEBNP_001264233.1 ANK 130..255 CDD:238125 26/137 (19%)
ANK 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00023 135..167 3/31 (10%)
ANK repeat 137..166 CDD:293786 2/28 (7%)
ANK 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00023 168..200 8/31 (26%)
ANK repeat 168..199 CDD:293786 8/30 (27%)
ANK 196..320 CDD:238125 20/82 (24%)
ANK 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00023 201..233 8/34 (24%)
ANK repeat 201..232 CDD:293786 8/33 (24%)
ANK 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00023 234..266 11/41 (27%)
ANK repeat 234..265 CDD:293786 9/39 (23%)
ANK 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00023 267..299
ANK repeat 267..298 CDD:293786
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..457
SMC_N <412..>542 CDD:330553
CCDC144C 489..>542 CDD:317340
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100127
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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