DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atx2 and ATXN2

DIOPT Version :9

Sequence 1:NP_732033.1 Gene:Atx2 / 41883 FlyBaseID:FBgn0041188 Length:1084 Species:Drosophila melanogaster
Sequence 2:NP_001359503.1 Gene:ATXN2 / 6311 HGNCID:10555 Length:1155 Species:Homo sapiens


Alignment Length:1219 Identity:288/1219 - (23%)
Similarity:427/1219 - (35%) Gaps:371/1219 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 NSKRKTRP------TGGGASGGISRYNSNDNSLRPTNNKAGAGGGNGGAAVRPSAQGVYNNTFFM 62
            :|...|.|      |.||...|:.| ..|.|...|.:.              .|..|:|.|...:
Human    60 SSSSATAPSSVVAATSGGGRPGLGR-GRNSNKGLPQST--------------ISFDGIYANMRMV 109

  Fly    63 HSATALVGSVVEVRLRSGNIYEGVFRTFSGNFDIALEL--PACIKSKNLPEEGKVPKHIIFPADT 125
            |..|::|||..||::::|.||||||:|:|...|:.|:.  ....:|.:.|:..::.:.|:|....
Human   110 HILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESILFKCSD 174

  Fly   126 VVTIVAKDFDSQYATAGAFQTDGAISDKCNGARPDEKELEPWDSG---ANGDIDIELDSAANGWD 187
            .|.:..||.||.||...|| ||.|||.|.||.. .||:|||||:|   ||.:::...:..:||||
Human   175 FVVVQFKDMDSSYAKRDAF-TDSAISAKVNGEH-KEKDLEPWDAGELTANEELEALENDVSNGWD 237

  Fly   188 PNEMFRKNENTFGVTSTFDDSLASYTVPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRDRLDLEN 252
            ||:|||.||..:||.||:|.||:||||||::.:|.||.:.||:|.:||.|||::...:.|:.|||
Human   238 PNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALEN 302

  Fly   253 GD--EEALFAAVERPSTEQDQRGDRGDRERNDRDREREERDRDRDRDRGNK--PRGAGDFQLRET 313
            .|  ||..:.||:|.|:                     ||:......|.||  |.|         
Human   303 DDRSEEEKYTAVQRNSS---------------------EREGHSINTRENKYIPPG--------- 337

  Fly   314 MSSDRYITKQTRSITGPQLSHVGMSSQGSGRDRDTRGDGSMMMQSGGGSGQGGSTQSTAAL---- 374
                    ::.|.:.          |.||||....|     |.|.|.||....||..|:..    
Human   338 --------QRNREVI----------SWGSGRQNSPR-----MGQPGSGSMPSRSTSHTSDFNPNS 379

  Fly   375 -----MLAGGLKGVGPAPSANASADSSSKYSGGSMVKRKTVPQGGKVMRNNVPTGGSNVSVSQGG 434
                 ::.||:....|.||  .|:...|:|..|.    .::|.     |...||...:...|:..
Human   380 GSDQRVVNGGVPWPSPCPS--PSSRPPSRYQSGP----NSLPP-----RAATPTRPPSRPPSRPS 433

  Fly   435 NGNSVGQNKGGYQPSMGMPSQYSYQGNSQIMHGSSQYRNQSHMGGANKLNGDSNANTNKPLPQRQ 499
            ...|.....|...|...||.:.|.:|..::                            .|..||.
Human   434 RPPSHPSAHGSPAPVSTMPKRMSSEGPPRM----------------------------SPKAQRH 470

  Fly   500 MRQYQGSQSNSSLNYGGEPQSLGKPVHGS---------HGG--------------------HPGQ 535
            .|.::.|....|::.|.|..|...|...:         .||                    .|.|
Human   471 PRNHRVSAGRGSISSGLEFVSHNPPSEAATPPVARTSPSGGTWSSVVSGVPRLSPKTHRPRSPRQ 535

  Fly   536 NS--NSP--------------------PLQTAGP-----------QQQQQQQQQQQQQQQQQQPP 567
            ||  |:|                    |:..|.|           ....:.:..:.|.|:|..|.
Human   536 NSIGNTPSGPVLASPQAGIIPTEAVAMPIPAASPTPASPASNRAVTPSSEAKDSRLQDQRQNSPA 600

  Fly   568 QQQQHQNIQP--------QGQNTQPARQVRTRDNQMQELRQFGQDFQLAPSNT------------ 612
            ..:  :||:|        :.:|...:..|.....|:.:|::|..||:|.||:|            
Human   601 GNK--ENIKPNETSPSFSKAENKGISPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLNKNR 663

  Fly   613 ----------------------------------------------------------------- 612
                                                                             
Human   664 EGEKSRDLIKDKIEPSAKDSFIENSSSNCTSGSSKPNSPSISPSILSNTEHKRGPEVTSQGVQTS 728

  Fly   613 SPPQQQQQQQQQQQQHQVQQQQQRALQQSA--------------SPPQQQQQQQQQQQHVVLHQV 663
            ||..:|::..:::::...:|.::..|..:|              :.|...:.|.|....:|.||.
Human   729 SPACKQEKDDKEEKKDAAEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQ 793

  Fly   664 PQTHLHQAALSQPHYV------PQQQP----QQAPLPQQQ-------HVPHHMQQKAQQQQLVET 711
            |.....|.....|:.:      |..||    ...|:|..|       .||:..||:       :.
Human   794 PTPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQR-------QD 851

  Fly   712 QHQHVQKQHQSQ---PQVQQPPP------------QLLQDPSQQPLPIYHTMPPPQTSPVVVTSP 761
            ||......|.:.   |.:...||            |....|..|.:|.|.:..|...|||:..:.
Human   852 QHHQSAMMHPASAAGPPIAATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNA 916

  Fly   762 VLLEQPPPQPMP-VVQQQQTQQLA---TPKPEVSPAPPSSNTTTPTGIASTPTAGVIASAGSEKT 822
            .:: .||....| :|....||..|   |......|..|.:..|:|:...:..|..:.........
Human   917 RMM-APPTHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNA 980

  Fly   823 TPAAPTPTSNSATVPTGTAATAGGATGTTPVVKKHVLNPSAKP----------------FTPRGP 871
            |....||....:..|||...:..|.:...|...:|..:.:|:.                ..|..|
Human   981 TLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPP 1045

  Fly   872 STPNPSRPHTPQT--PVPMTNIYTTTGGHVPPAANQPIYVMQPQHPFPPQTHPQAGQPPRLRRSN 934
            |....|...:||.  |.....::|....||     ||.|...|.....||.|.|:|..|....::
Human  1046 SMTPASNTQSPQNSFPAAQQTVFTIHPSHV-----QPAYTNPPHMAHVPQAHVQSGMVPSHPTAH 1105

  Fly   935 YP-------PMAASQMHVSASAATGQPLITAGPIPQFIQYG-HAPHQQQ 975
            .|       |....|..::.||....|:.|....|...... .|.||||
Human  1106 APMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQ 1154

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atx2NP_732033.1 SM-ATX 61..128 CDD:291131 22/68 (32%)
ATXN2NP_001359503.1 SM-ATX 105..181 CDD:373069 24/75 (32%)
PBP1 194..>339 CDD:227507 71/183 (39%)
LsmAD 249..310 CDD:369058 31/60 (52%)
PRK12323 <408..599 CDD:237057 37/227 (16%)
PAM2 750..765 CDD:336618 2/14 (14%)
PHA03247 <769..1087 CDD:223021 71/330 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 67 1.000 Domainoid score I9826
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 215 1.000 Inparanoid score I3623
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001866
OrthoInspector 1 1.000 - - otm41597
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12854
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2220
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
77.180

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