Protein Alignment Atx2 and atxn2

DIOPT Version :9

• Sequence 1: NP_732033.1
• Gene: Atx2 / 41883
• FlyBaseID: FBgn0041188
• Length: 1084
• Species: Drosophila melanogaster
• Sequence 2: NP_001121821.1
• Gene: atxn2 / 569210
• ZFINID: ZDB-GENE-060526-217
• Length: 1112
• Species: Danio rerio
• Alignment Length: 1231
• Identity: 318/1231 - (25%)
• Similarity: 462/1231 - (37%)
• Gaps: 341/1231 - (27%)

  Fly     3 NNSKRKTRPTGGGASGGISRYNSNDNSLRPTNNKAGAGGGNG-GAAVRPSAQGVYNNTFFMHSAT 66
            :||........|||.||:.|.|            .|.|..|. |.:...:..|||.|...:|..|
Zfish    16 SNSGAAAASGTGGAGGGVGRQN------------MGRGRNNAKGPSTAVAFNGVYANMRMVHVLT 68

  Fly    67 ALVGSVVEVRLRSGNIYEGVFRTFSGNFDIALELP--ACIKSKNLPEEGKVPKHIIFPADTVVTI 129
            ::||:..|:::::|.||||||:|:....||.|:..  ..::....|....:.:.|||.:..||.:
Zfish    69 SVVGTKCELKVKNGLIYEGVFKTYGPECDIVLDAAHRKSVEPNAGPRREDIVESIIFKSSDVVVV 133

  Fly   130 VAKDFDSQYATAGAFQTDGAISDKCNGARPDEKELEPWD------SGANGDIDIELDSAANGWDP 188
            ..||.|..||....| ||.|:|.:.||.. .||:|||||      ||:...:|.:|   :|||||
Zfish   134 HFKDVDLNYAKKDNF-TDSAVSARVNGEH-KEKDLEPWDGGEQHISGSMESLDTDL---SNGWDP 193

  Fly   189 NEMFRKNENTFGVTSTFDDSLASYTVPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRDRLDLENG 253
            :|||:.||.|:||.||:|.||:||||||::.:|.||.:.||:|.:||.|||.:.|.:.|:.|||.
Zfish   194 DEMFKYNEETYGVKSTYDSSLSSYTVPLERDNSEEFLKREARASQLAEEIEASATYKARVALEND 258

  Fly   254 D--EEALFAAVERPSTEQDQRGDRGDRERNDRDREREERDRDRDRDRGNKPRGAGDFQLRETMSS 316
            |  ||..:.||.           ||:||.:..:||
Zfish   259 DRSEEEKYTAVV-----------RGERELHSLNRE------------------------------ 282

  Fly   317 DRYITKQTRSITGPQLSHVGMSSQGSGRDRDTRGDGSMMMQSGGG---SGQGGSTQSTAALMLAG 378
            ::||....|:      ...|| |.|:||....|     ::|...|   ...|....:|....:..
Zfish   283 NKYIPPSQRN------REAGM-SWGAGRQVSPR-----LVQCSSGPPTPRSGPHDYNTIDQRVVN 335

  Fly   379 GLKGVGPAPSANASADS--SSKYSGG---SMVKR---KTVPQGGKVMRNNVP--------TGG-- 425
            |  |..|.||...|..|  .|:|..|   |:..|   .|.|......|.:.|        |.|
Zfish   336 G--GAQPWPSRCPSPSSRPPSRYQSGPTNSLPPRAATPTRPPSRPPSRPSRPLSHPSAHGTSGPL 398

  Fly   426 SNVSVSQGGNG--------------NSVGQNKGGYQPSMGMPSQYSYQGNSQIMHGSSQYRNQSH 476
            ||:.......|              :.|...:||..|    ||.|..||.|..:......|| |.
Zfish   399 SNMPKRLSSEGPPRMSPKSQRTPRPHRVASCRGGGPP----PSDYMSQGASVEVSAPPPTRN-SP 458

  Fly   477 MGG--ANKLNGDSNANTNKPLPQRQMRQYQGSQSNSSLNYGGEPQSLGKPVH---------GSHG 530
            .||  ::.::|     .::|...|| ....|...|||..  ..||:...||.         ....
Zfish   459 SGGTWSSVVSG-----AHRPRSPRQ-NSIGGEAPNSSCL--SSPQAGTVPVDSVTASTTATSPTA 515

  Fly   531 GHPGQNSNSPPLQTAGPQQQQQQQQQQQQQQQQQQPPQQQQHQNIQPQGQNTQPARQV------- 588
            .:|..|..:.|::.|         ::.:..:.:|..|...: :|::|...:...||.:
Zfish   516 ANPATNLEASPIEEA---------KESRVLETRQNSPNANK-ENVKPIEASPGIARSIGKGSPSM 570

  Fly   589 -RTRDNQMQELRQFGQDFQLAPSN----------TSPPQQQQQQQQQQQQHQ-------VQQQQQ 635
             .....|:..|::|...|:|.||:          |.||:...::.:.|...:       ::...:
Zfish   571 ASDHRKQIDNLKKFSAAFRLQPSSSSDPGFEAMGTKPPRDLGEKPKDQAAEKGSVDSTGLKASTE 635

  Fly   636 RALQQSASPPQQQQQQQQQQQHVVLHQVPQTHLHQAA----LSQPHYVPQQ--------QPQQAP 688
            .::.:..|.|                 |..|.....|    ||....||:|        |..|..
Zfish   636 SSISEETSSP-----------------VSVTSAGSKAGTPSLSPSSAVPEQKRGPDVTSQGVQTT 683

  Fly   689 LPQQQHVPHHMQQKAQQQQLVETQHQHVQKQ------HQSQPQVQQPPPQ-----LLQDPSQQPL 742
            .|....|.....:|..:...|.   :.|:|.      .:..|:|...||:     .|..|..||.
Zfish   684 SPLANAVTKDKDEKEDKNDPVA---ESVRKSTLNPNAKEFNPRVFCSPPKPATTPTLTRPQGQPS 745

  Fly   743 PIYHTMPPP--------QTSPVVVTSPVLLEQPPPQ---PMPVVQQQQTQQLATPKPEVSPA--- 793
            |......||        |..|:...||.:  |||..   .:|.:...||:...:.|.:..|.
Zfish   746 PSIVVQQPPTVYGQTMFQMYPLTPVSPGV--QPPAMYHVQVPHMTMSQTKSYRSGKVQNMPQQRP 808

  Fly   794 ----PPSSNTTTPTGIASTPTAGVIASAGSEKTTPAAPTPTSNSATVPTGTAATAGGATGTTPVV 854
                ||.::|...:..|:.|..             .||:|..::..........|     :.|:|
Zfish   809 DQHHPPGTSTMMHSATAAGPPI-------------VAPSPAYSTQYFTCSPQQFA-----SQPLV 855

  Fly   855 K---------KHVLNP----SAKPFTPRGPSTPNPSRPHTPQTPVPMTNIYTTTGGHVPPA---A 903
            :         :||.:|    ||:..||  |:...||...:..|... ...:|..|.:.|..   .
Zfish   856 QQMPHYQSQAQHVFSPVIQGSARMITP--PTHAQPSLVSSSTTQYG-EQTHTMYGKNFPSTMTKL 917

  Fly   904 NQPIY--VMQPQHPFPPQT---HPQAGQPPRLRRSNYPPMAASQMHVSASAATGQPLITAGPIPQ 963
            |:|.|  .:..|.|.|..|   |||..||                   ::..||||       .|
Zfish   918 NKPTYSTPIPQQFPHPSSTLHPHPQHPQP-------------------SATPTGQP-------QQ 956

  Fly   964 FIQYG--H-APHQQQFQSH--TYAPMQMRVYPDQPQQLQF---MTQTPQSTTPSPGQPHQQFHPP 1020
            ..|:|  | ||...|.|.|  ..|.....::...|||.|.   :..||.|.||.|.
Zfish   957 GTQHGGSHPAPSPVQHQQHQAAAAAAAQAIHLGNPQQQQMYSALAATPPSMTPGPN--------- 1012

  Fly  1021 PQPSPAGGGPQPAFTPPTQAATYQLMCVHPQSLLANHYFPPPTPQHPQQNQQQYQIVMQQH 1081
            ||      .||.:| |..|.|.|    :|||     |.:.|....|.||...|..:|...|
Zfish  1013 PQ------SPQASF-PSAQQAVY----IHPQ-----HGYNPNHMAHVQQAHMQSGMVPPHH 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atx2	NP_732033.1	SM-ATX	61..128	CDD:291131	21/68 (31%)
atxn2	NP_001121821.1	SM-ATX	62..131	CDD:291131	20/68 (29%)
		LsmAD	204..265	CDD:284215	32/60 (53%)
		PAM2	708..724	CDD:284542	3/15 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10144
eggNOG	1	0.900	-	-		E1_COG5180
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3537
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		otm26071
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12854
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	10.040