Protein Alignment Atx2 and atxn2l

DIOPT Version :9

• Sequence 1: NP_732033.1
• Gene: Atx2 / 41883
• FlyBaseID: FBgn0041188
• Length: 1084
• Species: Drosophila melanogaster
• Sequence 2: XP_005163856.1
• Gene: atxn2l / 324525
• ZFINID: ZDB-GENE-030131-3246
• Length: 1004
• Species: Danio rerio
• Alignment Length: 1249
• Identity: 322/1249 - (25%)
• Similarity: 460/1249 - (36%)
• Gaps: 441/1249 - (35%)

  Fly    10 RPTGGGASGGISRYNSNDNSLRPTNNKAGAGGGNGGAAVRPSA-----QGVYNNTFFMHSATALV 69
            |.|..|.||.::......||.||.      .|.|..:...||.     :|||||:..:|..||:|
Zfish    14 RKTSNGTSGSMASSVPGSNSNRPN------PGRNRNSVKTPSQSPPVFEGVYNNSRMLHFLTAVV 72

  Fly    70 GSVVEVRLRSGNIYEGVFRTFSGNFDIALELPACIKSKNLPEEG---------------KVPKHI 119
            ||..:|.:::|::|||:|:|.|...::|::  |..|.||  |||               ::...:
Zfish    73 GSRCDVMVKNGSLYEGIFKTLSSRCELAVD--AVHKVKN--EEGDGGGGGGTAVHPRKEEITDTM 133

  Fly   120 IFPADTVVTIVAKDFDSQYATAGAFQTDGAI-SDKCNGARPDEKELEPWDSG-ANGD-IDIELDS 181
            ||....:||::.:|.|..|||...| ||.|| |.:.||.. .||.|:.||.| :||: .|::.|:
Zfish   134 IFGPSDLVTMICRDVDLNYATRDTF-TDSAIGSSRLNGDH-REKVLQRWDGGDSNGENFDLDADT 196

  Fly   182 AANGWDPNEMFRKNENTFGVTSTFDDSLASYTVPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRD 246
             |||||.:||||.||.|:||.||:|.||:.|||||::|.|..|::.||:|.:||.|||.:...|.
Zfish   197 -ANGWDASEMFRFNEETYGVKSTYDSSLSMYTVPLERGSSEGFRQREARAARLANEIEASSQYRH 260

  Fly   247 RLDLENGD---EEALFAAVERPSTEQDQRGDRGDRERNDRDREREERDRDRDRDRGNKPRGAGDF 308
            |:.|||.:   :|..|:||.|                 ||:||..||:|.|| ..|....|:
Zfish   261 RVALENDEGRTDEDKFSAVVR-----------------DREREAAERERGRD-SPGFSSAGS--- 304

  Fly   309 QLRETMSSDRYITKQTRSITGPQLSHVGMSSQGSGRDRDTRGDGSMMMQSGGGSGQGGSTQSTAA 373
              ||    .:||..|.     .:...:|:|.:|.      || |::.......:..|.|:.|..
Zfish   305 --RE----GKYIPPQR-----AREREMGVSGRGE------RG-GAVSTLPNRTNRPGPSSSSPR- 350

  Fly   374 LMLAGGLKGVGPAPSANASADSSSKYSGGSMVKRKTVPQGGKVMRNNVPTGGSNVSVSQGGNGNS 438
                       |.||||:.|                           :|....|.|:|..| |.|
Zfish   351 -----------PLPSANSQA---------------------------LPPTDRNSSLSVRG-GFS 376

  Fly   439 VGQNKGGYQPSMGMPSQYSYQGNSQ------IMHGSSQYRNQSHMGGANKLNGDSNANTNKPLPQ 497
            ..|::.. .|:...||:   .|:|.      :.|..|..::.|.:  |..:||.|..:.......
Zfish   377 THQSQSS-TPTQSRPSE---PGHSSPPSPHTLSHSLSHPQSLSDV--ARPVNGVSPKSQRTGQTN 435

  Fly   498 RQMRQYQGSQSNSSLNYGGEPQSLGKP----VHGSHGGHPGQNSNSPPLQTAGPQQQQQQQQQQQ 558
            |.||.   |.|:||......|:....|    :.||:        ..|..:..||.........:.
Zfish   436 RNMRT---SNSHSSPTVSRSPKPDAPPQDPLLTGSY--------LDPSSKPVGPTPLFPVDVNEI 489

  Fly   559 QQQQQQQPPQQQQHQNIQPQGQNTQPARQVRTRDNQMQELRQFGQDFQLAPSNTSPPQQQQQQQQ 623
            ..:::.:.|       :.||...:.....|:.|....:|||:||..|:|
Zfish   490 LSKERMESP-------VGPQEGKSNKIPSVQQRSQISEELRKFGNTFRL---------------- 531

  Fly   624 QQQQHQVQQQQQRALQQSASPPQQQQQQQQQQQHVVLHQVPQTHLHQAALSQPHYVPQQQPQQAP 688
                                                                     ||.|:..|
Zfish   532 ---------------------------------------------------------QQNPKTLP 539

  Fly   689 LPQQQHVPHHMQQKAQQQQLVETQHQHVQKQHQSQPQVQQPPPQLLQDPSQQPLPIYHTMPPPQT 753
            ....|..|.|..|                                 .||:          .|.:.
Zfish   540 TESTQANPAHNTQ---------------------------------TDPA----------APTEA 561

  Fly   754 SPVVVTSPVLLEQPPPQPMPVVQQQQTQQLATPK-PEVSPAPPSSNTTTPTGIA--STPTAGVIA 815
            .|.          ||..|...:..::..:...|: |..|..||:::.:.|:||.  :.|..|..|
Zfish   562 KPA----------PPTTPNTELSAEERSRETNPEGPVTSTPPPATSISAPSGIGMQNPPAEGQTA 616

  Fly   816 SA-------GSEKTTPAAPTPTSNSATVPTGTAATAGGATGTTPVVKKHVLNPSAKPFTP-RGP- 871
            .|       |||...|.||..:.                 |.|..|||..|||:||.|.| :.|
Zfish   617 GAPQPARTPGSEDGKPEAPERSE-----------------GMTDQVKKSTLNPNAKEFNPTKAPL 664

  Fly   872 ------STPNPSRPHTPQTPVPMTNIYTTTGGHVPP-----AANQPIYV----MQPQHPFPPQTH 921
                  :||.|.|| ||.:|..:.......|....|     .:..||.:    :|||.|:...|.
Zfish   665 SMVKPSATPTPPRP-TPPSPTVVLQTQPGQGAVYNPQYLSYVSQVPIQIQGHSVQPQIPYSYMTA 728

  Fly   922 PQAGQPPRLR----------RSNYPPMAASQMHVSASAATGQPLITAGPIPQFIQYG-------H 969
            ...|:.||.:          .|:.|||      :.|::|.|.||:.:...|.::||.       |
Zfish   729 VSQGKYPRTKGSVVTPRPDHSSSAPPM------IQAASAAGPPLVASPYPPSYLQYNQVIPAMPH 787

  Fly   970 APHQQQFQSHTYAPMQM-------------RVYPDQ------PQQLQFMTQT---------PQ-S 1005
            .|..|.:......|..:             ..||.|      |||..:..|:         || |
Zfish   788 YPGHQVYSMLQGGPRMLGSGGHPQALGPPGPQYPGQTEGPSAPQQGMYAPQSFSHHSGSIHPQPS 852

  Fly  1006 TTPSPGQPHQQFHPPPQPSPAG-GGPQP----------AFTPP-------TQAATYQLM------ 1046
            :||:..||..| ||.|.|..:| .||||          |.|||       :..|:|.|.
Zfish   853 STPTGSQPPPQ-HPAPSPGQSGQSGPQPQSLYHSGPLSAPTPPNLPPGHSSPQASYSLQGYSLPG 916

  Fly  1047 ---CVHPQSLLA--------------NH---YFPPPT------------PQH---PQQNQQQY-- 1074
               ..||.|.|.              :|   :.|||.            |||   |||...|:
Zfish   917 HQPLPHPYSSLGQLTQAHVPGALSGPHHTGGHGPPPVMLLHAAPQQGSGPQHGPPPQQGAHQHFT 981

  Fly  1075 ----QIVMQQHQPQ 1084
                |:.:|.|.||
Zfish   982 YLGPQVPVQAHNPQ 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atx2	NP_732033.1	SM-ATX	61..128	CDD:291131	24/81 (30%)
atxn2l	XP_005163856.1	SM-ATX	63..142	CDD:291131	24/82 (29%)
		LsmAD	213..275	CDD:284215	29/61 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595196
Domainoid	1	1.000	64	1.000	Domainoid score	I10144
eggNOG	1	0.900	-	-		E1_COG5180
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3537
OMA	1	1.010	-	-		QHG49273
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		otm26071
orthoMCL	1	0.900	-	-		OOG6_108744
Panther	1	1.100	-	-	LDO	PTHR12854
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.880