DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atx2 and Atxn2

DIOPT Version :9

Sequence 1:NP_732033.1 Gene:Atx2 / 41883 FlyBaseID:FBgn0041188 Length:1084 Species:Drosophila melanogaster
Sequence 2:NP_033151.2 Gene:Atxn2 / 20239 MGIID:1277223 Length:1286 Species:Mus musculus


Alignment Length:1235 Identity:307/1235 - (24%)
Similarity:448/1235 - (36%) Gaps:399/1235 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 RPTGGG---------ASGGISRYNSNDNSLRP-TNNKAGAGGGNGG---------AAVRP--SAQ 53
            |..|||         ||..::..:.......| .::.|.||||..|         ...:|  |..
Mouse   166 RKPGGGLLSSPGAAPASAAVTSASVVPAPAAPVASSSAAAGGGRPGLGRGRNSSKGLPQPTISFD 230

  Fly    54 GVYNNTFFMHSATALVGSVVEVRLRSGNIYEGVFRTFSGNFDIALEL--PACIKSKNLPEEGKVP 116
            |:|.|...:|..|::|||..||::::|.||||||:|:|...|:.|:.  ....:|.:.|:..::.
Mouse   231 GIYANVRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIM 295

  Fly   117 KHIIFPADTVVTIVAKDFDSQYATAGAFQTDGAISDKCNGARPDEKELEPWDSG---ANGDIDIE 178
            :.::|.....|.:..||.||.||...|| ||.|:|.|.||.. .||:|||||:|   |:.::::|
Mouse   296 ESVLFKCSDFVVVQFKDTDSSYARRDAF-TDSALSAKVNGEH-KEKDLEPWDAGELTASEELELE 358

  Fly   179 LDSAANGWDPNEMFRKNENTFGVTSTFDDSLASYTVPLDKGDSLEFKEAEAKAEKLAAEIENNPT 243
            .| .:||||||:|||.||..:||.||:|.||:||||||::.:|.||.:.||:|.:||.|||::..
Mouse   359 ND-VSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQ 422

  Fly   244 CRDRLDLENGD--EEALFAAVERPSTEQDQRGDRGDRERNDRDREREERDRDRDRDRGNK--PRG 304
            .:.|:.|||.|  ||..:.||:|..::::..|.      |.||               ||  |.|
Mouse   423 YKARVALENDDRSEEEKYTAVQRNCSDREGHGP------NTRD---------------NKYIPPG 466

  Fly   305 AGDFQLRETMSSDRYITKQTRSITGPQLSHVGMSSQGSGRDRDTR----GDGSMMMQSGGGSGQG 365
            ..:   ||.:                        |.||||....|    |.|||..::...:...
Mouse   467 QRN---REVL------------------------SWGSGRQSSPRMGQPGPGSMPSRAASHTSDF 504

  Fly   366 GSTQSTAALMLAGGLKGVGPAPSANASADSSSKYSGGSMVKRKTVPQGGKVMRNNVPTGGSNVSV 430
            .....:...::.||:....|.||  .|:...|:|..|.    .::|.     |...||...:...
Mouse   505 NPNAGSDQRVVNGGVPWPSPCPS--PSSRPPSRYQSGP----NSLPP-----RAATPTRPPSRPP 558

  Fly   431 SQGGNGNSVGQNKGGYQPSMGMPSQYSYQGNSQIMHGSSQYRNQSHMGGANKLNGDSNANTNKPL 495
            |:.....|.....|...|...||.:.|.:|..::                            .|.
Mouse   559 SRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRM----------------------------SPK 595

  Fly   496 PQRQMRQYQGSQSNSSLNYGGEPQSLGKPVHGSHGGHPGQNSNSPPLQTAGPQQQQQQQQQQQQQ 560
            .||..|.::.|....|::.|.|                 ..|::||.:.|.|...:         
Mouse   596 AQRHPRNHRVSAGRGSMSSGLE-----------------FVSHNPPSEAAAPPVAR--------- 634

  Fly   561 QQQQQPPQQQQHQNIQPQGQNTQPARQVRTRDNQMQELRQFGQDFQLAPSNT---SPPQQQQQQQ 622
                                 |.||                |..:....|..   ||        
Mouse   635 ---------------------TSPA----------------GGTWSSVVSGVPRLSP-------- 654

  Fly   623 QQQQQHQVQQQQQRALQQSASPPQQQQQQQQQQQHVVLHQVPQTHLHQA-ALSQPHYVPQQQPQQ 686
               :.|:.:..:|.::..|.|.|             ||.. ||..:..| |:|.|  ||...|..
Mouse   655 ---KTHRPRSPRQSSIGNSPSGP-------------VLAS-PQAGIIPAEAVSMP--VPAASPTP 700

  Fly   687 A-PLPQQQHVPHHMQQKAQQQQLVETQHQHVQKQHQSQPQVQQPPPQLLQDPSQQPLPIYHTMPP 750
            | |...:...|.           :|.:...:|.|.|:.|.           .|::.:....|.|.
Mouse   701 ASPASNRALTPS-----------IEAKDSRLQDQRQNSPA-----------GSKENVKASETSPS 743

  Fly   751 PQTSPVVVTSPVLLE-----------------QPPPQPMPVVQ-------QQQTQQLATPKPEVS 791
            ...:.....|||:.|                 ||......:.|       .::::.|...|.|.|
Mouse   744 FSKADNKGMSPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLSKNREGEKSRDLIKDKTEAS 808

  Fly   792 -------PAPPSSNTTTPTGIASTPTAGVIASAGSEKTTPAAPTPTS-NSATVPTGTAATAGGAT 848
                   .:..|||.|                :||.||...:.:|:. ::|....|...|:.|..
Mouse   809 AKDSFIDSSSSSSNCT----------------SGSSKTNSPSISPSMLSNAEHKRGPEVTSQGVQ 857

  Fly   849 GTTPV-----------------VKKHVLNPSAKPFTPRGPSTPNPSRPHTPQTPVPMTNIYTTTG 896
            .::|.                 |:|..|||:||.|.||..|.|.||.  ||.:|.|......:..
Mouse   858 TSSPACKQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFSQPKPST--TPTSPRPQAQPSPSMV 920

  Fly   897 GHVPPAANQPIYV------------------MQPQHPFPPQTHP-------QAGQPPRLRRSNYP 936
            ||..||   |:|.                  :||.:|.|....|       :||:.|     |.|
Mouse   921 GHQQPA---PVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVP-----NMP 977

  Fly   937 PMAASQMHVSA----SAATGQPLITAGPI--PQFIQYG-----------HAPHQQQFQSHTYAPM 984
            .....|.|.|.    ::|.|.|::...|.  .|::.|.           |.||.|....|.|:|:
Mouse   978 QQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPV 1042

  Fly   985 -----QMRVYP--DQP-------------QQLQFMTQTP-----QSTTP------SPGQPHQQF- 1017
                 :|...|  .||             :|...|...|     :.|:|      |.|...||: 
Mouse  1043 IQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYA 1107

  Fly  1018 HPPPQPSPAGGGPQPAFTPPTQAATYQLMCVHPQSLLANHYFPPPTPQHPQQNQQQYQIVMQQHQ 1082
            ||.....|....|||:.||     |.|....|..|    |..|.|...|..|..|...:...|.|
Mouse  1108 HPNAALHPHTPHPQPSATP-----TGQQQSQHGGS----HPAPSPVQHHQHQAAQALHLASPQQQ 1163

  Fly  1083  1082
            Mouse  1164  1163

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atx2NP_732033.1 SM-ATX 61..128 CDD:291131 21/68 (31%)
Atxn2NP_033151.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..85
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..178 4/11 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 197..224 7/26 (27%)
SM-ATX 237..306 CDD:291131 21/68 (31%)
LsmAD 378..439 CDD:284215 31/60 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..925 142/713 (20%)
PAM2 880..896 CDD:284542 9/15 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1111..1191 18/62 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 66 1.000 Domainoid score I9911
eggNOG 1 0.900 - - E1_COG5180
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 209 1.000 Inparanoid score I3669
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001866
OrthoInspector 1 1.000 - - otm43645
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12854
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2220
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
99.040

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