Protein Alignment Atx2 and atxn2

DIOPT Version :10

• Sequence 1: NP_732033.1
• Gene: Atx2 / 41883
• FlyBaseID: FBgn0041188
• Length: 1084
• Species: Drosophila melanogaster
• Sequence 2: XP_002937742.3
• Gene: atxn2 / 100490147
• XenbaseID: XB-GENE-920190
• Length: 1082
• Species: Xenopus tropicalis
• Alignment Length: 1184
• Identity: 283/1184 - (23%)
• Similarity: 425/1184 - (35%)
• Gaps: 324/1184 - (27%)

  Fly     1 MNNNSKRKTRPTGGG--ASGGISRYNSNDNSLRPTNNKAGAGGGNG-GAAVRPSAQGVYNNTFFM 62
            |...:....:|.||.  |:|| .|.|            .|.|..:| |.....|..|:|.|...:
 Frog     3 MKQQAGNNRKPGGGSVPAAGG-GRQN------------MGRGRSSGKGPPQSISFDGIYANMRLV 54

  Fly    63 HSATALVGSVVEVRLRSGNIYEGVFRTFSGNFDIALELPACIKSKNL--PEEGKVPKHIIFPADT 125
            |..|::|||..||.:::|:||||||:|:|...|:.|:......::::  |:...:...|:|.:..
 Frog    55 HILTSVVGSKCEVFVKNGSIYEGVFKTYSPKCDLVLDAAHKKTTESIVGPKREDIVDSILFKSSD 119

  Fly   126 VVTIVAKDFDSQYATAGAFQTDGAISDKCNGARPDEKELEPWDSGAN-----GDIDIELDS---- 181
            .|.:..||.|..||....| ||..|:.:.||.. .||:||||:.|.|     ..:..||||
 Frog   120 FVMVQFKDMDVNYARRDGF-TDSGIASRLNGEH-KEKDLEPWNGGENLISSASTVSEELDSLETD 182

  Fly   182 AANGWDPNEMFRKNENTFGVTSTFDDSLASYTVPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRD 246
            .:||||||||||.||..:||.||:|.||:||||||::.:|.|:.:.||:|.::|.|||::...:.
 Frog   183 VSNGWDPNEMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEYLKREARAAQIAEEIESSSQYKA 247

  Fly   247 RLDLENGD--EEALFAAVERPSTEQDQRGDRGDRERNDRDREREERDRDRDRDRGNKPRGAGDFQ 309
            |:.|||.:  ||..:.||:|...|      |.....|.|:
 Frog   248 RVALENDERSEEEKYTAVQRSLME------REGHSLNTRE------------------------- 281

  Fly   310 LRETMSSDRYITKQTRSITGPQLSHVGMSSQGSGRDRDTR----GDGSMMMQSGGGSGQGGSTQS 370
                   ::||....|:      ....:.:..|||....|    |.|.:..::|..|........
 Frog   282 -------NKYIPPVQRN------KDAMLWTTHSGRQTSARIGQSGSGPIPSRTGSHSSDYSPNAG 333

  Fly   371 TAALMLAGGLKGVGPAPSANASADSSSKYSGGSMVKRKTVPQGGKVMRNNVPTGGSNVSVSQGGN 435
            ....::.||:....|.||  .|:...|:|..|.    .::|.     |...||...:...|:...
 Frog   334 ADQRVINGGVPWPSPCPS--PSSRPPSRYQSGP----NSLPP-----RAATPTRPPSRPPSRPSR 387

  Fly   436 GNSVGQNKGGYQPSMGMPSQYSYQGNSQIMHGSSQYRNQSHM---GGANKLNGDSNANTNKP--- 494
            ..|.....|...|...||.:.|.:|..: |...:|...::|.   |......|....:.|:|
 Frog   388 PPSHPSAHGSPAPVSTMPKRMSSEGPPR-MSPKAQRHPRTHRVSNGRGTICGGLEFVSRNEPGEV 451

  Fly   495 LPQRQMRQYQGSQSNSSLNYGGEPQSLGKPVH-------GSHGGHPGQNSNSPPLQTAGPQQQQQ 552
            ..|...|......:.||:..|  .|.|....|       |||.  ||.|.:||...|..|
 Frog   452 SAQPVARNSSSGGTWSSVVSG--VQRLSPKTHRPRSPRLGSHA--PGSNVSSPQPSTVPP----- 507

  Fly   553 QQQQQQQQQQQQQPPQQQQHQNIQPQGQNTQPARQVRTRDNQMQELRQFGQDFQLAPSNTSPPQQ 617
            :............|.....::.:.|         ....:|:::|:.||           .||...
 Frog   508 ESVSMPVPAASPTPASPASNRAVTP---------SCEAKDSRLQDQRQ-----------NSPAAC 552

  Fly   618 QQQQQQQQQQHQVQQQQQRALQQSASPPQQQQQQQQQQQHVVLHQVPQTHLHQAALSQPHYVPQQ 682
            ::..:|.:....       ..:...||...:|::|...
 Frog   553 RENSKQSESSCS-------KTENKVSPMASEQRKQLDD--------------------------- 583

  Fly   683 QPQQAPLPQQQHVPHHMQQKAQQQQLVETQHQHVQKQHQSQPQVQQPPPQLLQDPSQQPLPIYHT 747
                                              .|:.::..::|         ||..|..:.|
 Frog   584 ----------------------------------LKKFKNDFRLQ---------PSSSPEALDH- 604

  Fly   748 MPPPQTSPVVVTSPVLLEQPPPQPMPVVQQQQTQQLATPKPEVSPAPPSSNTTTPTGIASTPTAG 812
                    :.:.:...:|:|..   ||.::.......:.....|.|..|:|::.|:..:.:|:
 Frog   605 --------LTIKNRDSVEKPRD---PVKEKVDANNKESTSESSSNATTSNNSSKPSSPSISPS-- 656

  Fly   813 VIASAGSEKTTPAAPTPTSNSATVPTGTAATAGGA-----------TGTTPVVKKHVLNPSAKPF 866
             |.|:|||.  ...|..||..       ..|:|.:           ......|:|..|||:||.|
 Frog   657 -IISSGSEH--KRGPEVTSQG-------VQTSGPSKQDRDDKDDRKENAAEQVRKSTLNPNAKEF 711

  Fly   867 TPRGPSTPNPSRPHTPQTPVPMTNIYTTTGGHVPPAANQPIYV------------------MQPQ 913
            .||..:.|.||.  ||.:|.|.|....:..||..|.   |:|.                  :||.
 Frog   712 NPRSYAQPKPST--TPTSPRPQTQPSPSVVGHQQPT---PVYTQPVCFAPNMMYPVPVSPGVQPL 771

  Fly   914 HPFPPQTHP-------QAGQPPRLRRSNYPPMAASQMHVSAS----AATGQPLITAGPI--PQFI 965
            :..|..|.|       :||:.|     |.|.....|.|.:..    :|.|.|::...|.  .|::
 Frog   772 YSIPMTTMPVNQAKTYRAGKVP-----NMPQQRQDQHHQNTMMHPVSAAGPPIVATPPAYSAQYV 831

  Fly   966 QYG-----------HAPHQQQFQSHTYAPM-----QMRVYPDQPQQLQFMTQTPQSTTPSPGQPH 1014
            .|.           |..|.|....|.|:|:     :|...|...|.....:...|..||.  |.|
 Frog   832 AYSPQQFPNQPLMQHVQHYQSQHPHVYSPVIQGNTRMMAPPSHAQAGLVSSSAAQYATPE--QTH 894

  Fly  1015 ----------QQF-HPPPQPSPAGGGPQPAFTPPTQAATYQLMCVHPQSLLANHYFPPPTPQHPQ 1068
                      ||: ||.....|....|||:.||     |.|....|..|    |..|.|...|..
 Frog   895 TMYVSTSSLAQQYAHPNAALHPHPPHPQPSATP-----TGQQQSQHGGS----HPAPSPVQHHQH 950

  Fly  1069 QNQQQYQIVMQQHQ 1082
            |..|...:..||.|
 Frog   951 QASQALHLANQQQQ 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atx2	NP_732033.1	SM-ATX	61..132	CDD:464173	22/72 (31%)
		dermokine	<400..>542	CDD:455732	36/154 (23%)
		PHA03247	<749..1032	CDD:223021	81/351 (23%)
atxn2	XP_002937742.3	SM-ATX	53..126	CDD:464173	22/72 (31%)
		LsmAD	200..261	CDD:461998	28/60 (47%)
		PHA03247	<364..746	CDD:223021	97/526 (18%)
		PRK12323	<450..591	CDD:481241	32/237 (14%)
		PAT1	826..>1082	CDD:401645	39/150 (26%)