Protein Alignment Atx2 and atxn2

DIOPT Version :9

• Sequence 1: NP_732033.1
• Gene: Atx2 / 41883
• FlyBaseID: FBgn0041188
• Length: 1084
• Species: Drosophila melanogaster
• Sequence 2: XP_002937742.3
• Gene: atxn2 / 100490147
• XenbaseID: XB-GENE-920190
• Length: 1082
• Species: Xenopus tropicalis
• Alignment Length: 1184
• Identity: 283/1184 - (23%)
• Similarity: 425/1184 - (35%)
• Gaps: 324/1184 - (27%)

  Fly     1 MNNNSKRKTRPTGGG--ASGGISRYNSNDNSLRPTNNKAGAGGGNG-GAAVRPSAQGVYNNTFFM 62
            |...:....:|.||.  |:|| .|.|            .|.|..:| |.....|..|:|.|...:
 Frog     3 MKQQAGNNRKPGGGSVPAAGG-GRQN------------MGRGRSSGKGPPQSISFDGIYANMRLV 54

  Fly    63 HSATALVGSVVEVRLRSGNIYEGVFRTFSGNFDIALELPACIKSKNL--PEEGKVPKHIIFPADT 125
            |..|::|||..||.:::|:||||||:|:|...|:.|:......::::  |:...:...|:|.:..
 Frog    55 HILTSVVGSKCEVFVKNGSIYEGVFKTYSPKCDLVLDAAHKKTTESIVGPKREDIVDSILFKSSD 119

  Fly   126 VVTIVAKDFDSQYATAGAFQTDGAISDKCNGARPDEKELEPWDSGAN-----GDIDIELDS---- 181
            .|.:..||.|..||....| ||..|:.:.||.. .||:||||:.|.|     ..:..||||
 Frog   120 FVMVQFKDMDVNYARRDGF-TDSGIASRLNGEH-KEKDLEPWNGGENLISSASTVSEELDSLETD 182

  Fly   182 AANGWDPNEMFRKNENTFGVTSTFDDSLASYTVPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRD 246
            .:||||||||||.||..:||.||:|.||:||||||::.:|.|:.:.||:|.::|.|||::...:.
 Frog   183 VSNGWDPNEMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEYLKREARAAQIAEEIESSSQYKA 247

  Fly   247 RLDLENGD--EEALFAAVERPSTEQDQRGDRGDRERNDRDREREERDRDRDRDRGNKPRGAGDFQ 309
            |:.|||.:  ||..:.||:|...|      |.....|.|:
 Frog   248 RVALENDERSEEEKYTAVQRSLME------REGHSLNTRE------------------------- 281

  Fly   310 LRETMSSDRYITKQTRSITGPQLSHVGMSSQGSGRDRDTR----GDGSMMMQSGGGSGQGGSTQS 370
                   ::||....|:      ....:.:..|||....|    |.|.:..::|..|........
 Frog   282 -------NKYIPPVQRN------KDAMLWTTHSGRQTSARIGQSGSGPIPSRTGSHSSDYSPNAG 333

  Fly   371 TAALMLAGGLKGVGPAPSANASADSSSKYSGGSMVKRKTVPQGGKVMRNNVPTGGSNVSVSQGGN 435
            ....::.||:....|.||  .|:...|:|..|.    .::|.     |...||...:...|:...
 Frog   334 ADQRVINGGVPWPSPCPS--PSSRPPSRYQSGP----NSLPP-----RAATPTRPPSRPPSRPSR 387

  Fly   436 GNSVGQNKGGYQPSMGMPSQYSYQGNSQIMHGSSQYRNQSHM---GGANKLNGDSNANTNKP--- 494
            ..|.....|...|...||.:.|.:|..: |...:|...::|.   |......|....:.|:|
 Frog   388 PPSHPSAHGSPAPVSTMPKRMSSEGPPR-MSPKAQRHPRTHRVSNGRGTICGGLEFVSRNEPGEV 451

  Fly   495 LPQRQMRQYQGSQSNSSLNYGGEPQSLGKPVH-------GSHGGHPGQNSNSPPLQTAGPQQQQQ 552
            ..|...|......:.||:..|  .|.|....|       |||.  ||.|.:||...|..|
 Frog   452 SAQPVARNSSSGGTWSSVVSG--VQRLSPKTHRPRSPRLGSHA--PGSNVSSPQPSTVPP----- 507

  Fly   553 QQQQQQQQQQQQQPPQQQQHQNIQPQGQNTQPARQVRTRDNQMQELRQFGQDFQLAPSNTSPPQQ 617
            :............|.....::.:.|         ....:|:::|:.||           .||...
 Frog   508 ESVSMPVPAASPTPASPASNRAVTP---------SCEAKDSRLQDQRQ-----------NSPAAC 552

  Fly   618 QQQQQQQQQQHQVQQQQQRALQQSASPPQQQQQQQQQQQHVVLHQVPQTHLHQAALSQPHYVPQQ 682
            ::..:|.:....       ..:...||...:|::|...
 Frog   553 RENSKQSESSCS-------KTENKVSPMASEQRKQLDD--------------------------- 583

  Fly   683 QPQQAPLPQQQHVPHHMQQKAQQQQLVETQHQHVQKQHQSQPQVQQPPPQLLQDPSQQPLPIYHT 747
                                              .|:.::..::|         ||..|..:.|
 Frog   584 ----------------------------------LKKFKNDFRLQ---------PSSSPEALDH- 604

  Fly   748 MPPPQTSPVVVTSPVLLEQPPPQPMPVVQQQQTQQLATPKPEVSPAPPSSNTTTPTGIASTPTAG 812
                    :.:.:...:|:|..   ||.::.......:.....|.|..|:|::.|:..:.:|:
 Frog   605 --------LTIKNRDSVEKPRD---PVKEKVDANNKESTSESSSNATTSNNSSKPSSPSISPS-- 656

  Fly   813 VIASAGSEKTTPAAPTPTSNSATVPTGTAATAGGA-----------TGTTPVVKKHVLNPSAKPF 866
             |.|:|||.  ...|..||..       ..|:|.:           ......|:|..|||:||.|
 Frog   657 -IISSGSEH--KRGPEVTSQG-------VQTSGPSKQDRDDKDDRKENAAEQVRKSTLNPNAKEF 711

  Fly   867 TPRGPSTPNPSRPHTPQTPVPMTNIYTTTGGHVPPAANQPIYV------------------MQPQ 913
            .||..:.|.||.  ||.:|.|.|....:..||..|.   |:|.                  :||.
 Frog   712 NPRSYAQPKPST--TPTSPRPQTQPSPSVVGHQQPT---PVYTQPVCFAPNMMYPVPVSPGVQPL 771

  Fly   914 HPFPPQTHP-------QAGQPPRLRRSNYPPMAASQMHVSAS----AATGQPLITAGPI--PQFI 965
            :..|..|.|       :||:.|     |.|.....|.|.:..    :|.|.|::...|.  .|::
 Frog   772 YSIPMTTMPVNQAKTYRAGKVP-----NMPQQRQDQHHQNTMMHPVSAAGPPIVATPPAYSAQYV 831

  Fly   966 QYG-----------HAPHQQQFQSHTYAPM-----QMRVYPDQPQQLQFMTQTPQSTTPSPGQPH 1014
            .|.           |..|.|....|.|:|:     :|...|...|.....:...|..||.  |.|
 Frog   832 AYSPQQFPNQPLMQHVQHYQSQHPHVYSPVIQGNTRMMAPPSHAQAGLVSSSAAQYATPE--QTH 894

  Fly  1015 ----------QQF-HPPPQPSPAGGGPQPAFTPPTQAATYQLMCVHPQSLLANHYFPPPTPQHPQ 1068
                      ||: ||.....|....|||:.||     |.|....|..|    |..|.|...|..
 Frog   895 TMYVSTSSLAQQYAHPNAALHPHPPHPQPSATP-----TGQQQSQHGGS----HPAPSPVQHHQH 950

  Fly  1069 QNQQQYQIVMQQHQ 1082
            |..|...:..||.|
 Frog   951 QASQALHLANQQQQ 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atx2	NP_732033.1	SM-ATX	61..128	CDD:291131	21/68 (31%)
atxn2	XP_002937742.3	SM-ATX	53..126	CDD:405176	22/72 (31%)
		PBP1	139..>290	CDD:227507	66/189 (35%)
		LsmAD	200..261	CDD:399606	28/60 (47%)
		PHA03247	<364..746	CDD:223021	97/526 (18%)
		PRK14971	<450..591	CDD:237874	32/237 (14%)
		PHA03378	<702..944	CDD:223065	69/262 (26%)
		KLF1_2_4_N	<935..1046	CDD:425360	11/34 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9783
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3333
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		otm48809
Panther	1	1.100	-	-	O	PTHR12854
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.150