DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6125 and SUL1

DIOPT Version :9

Sequence 1:	NP_732032.1	Gene:	CG6125 / 41882	FlyBaseID:	FBgn0038337	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_009853.3	Gene:	SUL1 / 852597	SGDID:	S000000498	Length:	859	Species:	Saccharomyces cerevisiae

Alignment Length:	633	Identity:	180/633 - (28%)
Similarity:	289/633 - (45%)	Gaps:	115/633 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KRNGRNRSSGEATGGQPQATVATIYD--PGCEEKEKYTAQNGDDYYGQAHTVDLDVASKYSKPKE 76
            :.|.:..||.:..|.........:||  |..||    :.....:||.  |::..::.:|    ..
Yeast    45 EENWKVNSSKQKFGVTKNELSDVLYDSIPAYEE----STVTLKEYYD--HSIKNNLTAK----SA 99

  Fly    77 AHWLVRRIFFLSWITSYDREQAFADLIAGITLGLTIIPQSIAYAALAGLSSEYGLYSAFIGSIIY 141
            ..:||.....:.|...|:....:|||:||||:|..::|||::||.:|.||.||||||:|||:.||
Yeast   100 GSYLVSLFPIIKWFPHYNFTWGYADLVAGITVGCVLVPQSMSYAQIASLSPEYGLYSSFIGAFIY 164

  Fly   142 VFFGTIPQVSIGPTSLMAILTLQFCAD-------------KPVQVVIVLAFLAGLVELAMGVFQL 193
            ..|.|...|.|||.::|::.|.:..|:             .|: :...|..|.|:|...:|:.:|
Yeast   165 SLFATSKDVCIGPVAVMSLQTAKVIAEVLKKYPEDQTEVTAPI-IATTLCLLCGIVATGLGILRL 228

  Fly   194 GFIVSFIPAPVTKAFTSGTALIVVFAQIKNLLGVR----------------IKGFPSIGDFFTNI 242
            ||:|..|.......|.:|:|..:::.||..|:|..                :|..|:     |.:
Yeast   229 GFLVELISLNAVAGFMTGSAFNIIWGQIPALMGYNSLVNTREATYKVVINTLKHLPN-----TKL 288

  Fly   243 RPTDAAMGISCMVVLLSLR--------LLSQVNFKQDTPVTRRLKKILWYISISRNALV-VFFTG 298
               ||..|:..:|:|...:        .|:...::....|..|||...:|....|||:| |.||.
Yeast   289 ---DAVFGLIPLVILYVWKWWCGTFGITLADRYYRNQPKVANRLKSFYFYAQAMRNAVVIVVFTA 350

  Fly   299 LLVFIWVKKSSIEAVPFALSSKVSSAMPTI---KLPPFAFEYQNRTYVFTDILHELGSGIVVVPI 360
            :...|...|||.:. |.::...|.|.:..:   |:|             ..:|..:.|.|....|
Yeast   351 ISWSITRNKSSKDR-PISILGTVPSGLNEVGVMKIP-------------DGLLSNMSSEIPASII 401

  Fly   361 VAVLANVAIAKAF--VKDGNLDASQEMLTLGLCNIAGSFFSAMPTCGAFTRSAVSQASGVRTPMA 423
            |.||.::||:|:|  :.|..:...||::.:|:.|:.|:||.:.|..|:|:|||:.....||||.:
Yeast   402 VLVLEHIAISKSFGRINDYKVVPDQELIAIGVTNLIGTFFHSYPATGSFSRSALKAKCNVRTPFS 466

  Fly   424 GIYTGLIVLSALSILTPYFQYIPKASLSAVLIAAVI-FMIDLAPVKELWQTNKKDFFSWVGSFII 487
            |::||..||.||..||..|.:||||:||||:|.||. .:.........|:||..|..|::.:..|
Yeast   467 GVFTGGCVLLALYCLTDAFFFIPKATLSAVIIHAVSDLLTSYKTTWTFWKTNPLDCISFIVTVFI 531

  Fly   488 CLVAGVELGLLFGIVLSMVFILLRLGNP--KFEVTLKQHESTYYVHIVPQSDVYYTGVDALRSEL 550
            .:.:.:|.|:.|.:..|...:||:...|  ||   |.:.|....::...|.|     :||:.|.
Yeast   532 TVFSSIENGIYFAMCWSCAMLLLKQAFPAGKF---LGRVEVAEVLNPTVQED-----IDAVISS- 587

  Fly   551 RGACRLYHNDFPVVLD-----------------CARFMQFDATFSEML 581
                    |:.|..|:                 ..:::.||..:|..|
Yeast   588 --------NELPNELNKQVKSTVEVLPAPEYKFSVKWVPFDHGYSREL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6125	NP_732032.1	sulP	87..620	CDD:273284	165/558 (30%)
		HCO3_cotransp	108..462	CDD:304903	127/397 (32%)
		STAS	530..608	CDD:294402	12/69 (17%)
SUL1	NP_009853.3	SUL1	102..784	CDD:223732	167/566 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341582
Domainoid	1	1.000	211	1.000	Domainoid score	I497
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I705
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		mtm9191
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
TreeFam	1	0.960	-	-
	11	10.850