DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6125 and SLC26A6

DIOPT Version :9

Sequence 1:	NP_732032.1	Gene:	CG6125 / 41882	FlyBaseID:	FBgn0038337	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_075062.2	Gene:	SLC26A6 / 65010	HGNCID:	14472	Length:	759	Species:	Homo sapiens

Alignment Length:	640	Identity:	159/640 - (24%)
Similarity:	288/640 - (45%)	Gaps:	127/640 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 DYY------GQAHTVDLDVASKY-SKPKEAHW--------------LVRRIFFLSWITSYD-REQ 97
            ||:      .|.|   |:...:: |.|:...|              |::.:..|.|:..|. |:.
Human    28 DYHMERPLLNQEH---LEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDW 89

  Fly    98 AFADLIAGITLGLTIIPQSIAYAALAGLSSEYGLYSAFIGSIIYVFFGTIPQVSIGPTSLMAI-- 160
            ...||::|:::.:..:||.:|||.||||...:||||:|....||..|||...:|:|..::|::
Human    90 LLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMV 154

  Fly   161 ------LTLQFCADK----------PVQVVIVLAFLAGLVELAMGVFQLGFIVSFIPAPVTKAFT 209
                  |..|...|.          .|||...|:.|.||.::.:|:...||:|:::..|:.:.:|
Human   155 GSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYT 219

  Fly   210 SGTALIVVFAQIKNLLGVRIKGFPS-IGDFFTNIR-------------PTDAAMGISCMVV-LLS 259
            :..|:.|..:|:|.:.|:.:..... :...:|.:.             .|.|..|:..:|| ||:
Human   220 TAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLN 284

  Fly   260 LRLLSQVNFKQDTPVTRRLKKILWYISISRNALVVFFTGLLVFIWVKKSSIEAVPFALSSKVSSA 324
            .:|..|:    ..|:...|..::....||      :..||       |...|.       .|...
Human   285 DKLQQQL----PMPIPGELLTLIGATGIS------YGMGL-------KHRFEV-------DVVGN 325

  Fly   325 MPTIKLPPFAFEYQNRTYVFTDILHELGSGIVVVPIVAVLANVAIAKAF-VKDG-NLDASQEMLT 387
            :|...:||.|    ..|.:|:.:   :||...:. :|.....:::.|.| ::.| .:|::||::.
Human   326 IPAGLVPPVA----PNTQLFSKL---VGSAFTIA-VVGFAIAISLGKIFALRHGYRVDSNQELVA 382

  Fly   388 LGLCNIAGSFFSAMPTCGAFTRSAVSQASGVRTPMAGIYTGLIVLSALSILTPYFQYIPKASLSA 452
            |||.|:.|..|...|...:.:||.|.:::|..:.:||..:.|.:|..:..|...|..:|||.|:|
Human   383 LGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAA 447

  Fly   453 VLIAAVIFMI-DLAPVKELWQTNKKDFFSWVGSFIICLVAGVELGLLFGIVLSMVFILLRLGNPK 516
            ::|..:..|: .|:.::.||:.|:.|...|:.:|...::..::|||:..::.|::.:::|...|.
Human   448 IIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPH 512

  Fly   517 FEVTLKQHESTYYVHIVPQSDVYYTGVD-ALRSELRGACRLYHNDFPVVLDCARFMQFDATFSEM 580
            :.| |.|         ||.:|:|....: :...|:||. :::.:...|....|.|      :|:.
Human   513 YSV-LGQ---------VPDTDIYRDVAEYSEAKEVRGV-KVFRSSATVYFANAEF------YSDA 560

  Fly   581 LISVAKEMASHDV-LLILQNMS-LKVQQMLPVMGNVRFCQEDSQLSSHLQVEKEA 633
            |    |:....|| .||.|... ||.|:.|.:          .||....::.|:|
Human   561 L----KQRCGVDVDFLISQKKKLLKKQEQLKL----------KQLQKEEKLRKQA 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6125	NP_732032.1	sulP	87..620	CDD:273284	146/572 (26%)
		HCO3_cotransp	108..462	CDD:304903	100/388 (26%)
		STAS	530..608	CDD:294402	21/80 (26%)
SLC26A6	NP_075062.2	sulP	76..738	CDD:273284	150/589 (25%)
		HCO3_cotransp	<299..451	CDD:304903	45/179 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..657
		STAS_SulP_like_sulfate_transporter	<656..735	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810