DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6125 and SLC26A4

DIOPT Version :9

Sequence 1:	NP_732032.1	Gene:	CG6125 / 41882	FlyBaseID:	FBgn0038337	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_000432.1	Gene:	SLC26A4 / 5172	HGNCID:	8818	Length:	780	Species:	Homo sapiens

Alignment Length:	740	Identity:	168/740 - (22%)
Similarity:	289/740 - (39%)	Gaps:	230/740 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LSWITSYD-REQAFADLIAGITLGLTIIPQSIAYAALAGLSSEYGLYSAFIGSIIYVFFGTIPQV 150
            |.|:..|. :|...:|:|:|::.||....|.:|||.||.:...|||||||...:.|..|||...:
Human    72 LEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHI 136

  Fly   151 SIGPTSLMAIL----TLQFCADK-------------------------PVQVVIVLAFLAGLVEL 186
            |:||..:::::    .|....|:                         .|.:...|..|.|:::|
Human   137 SVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQL 201

  Fly   187 AMGVFQLGFIVSFIPAPVTKAFTSGTALIVVFAQIKNLLGVRIKG--------------FPSIGD 237
            ..|..|:||||.::..|:...||:..|..|:.:|:|.:|.|..|.              |.:|||
Human   202 IFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGD 266

  Fly   238 FFTNIRPTDAAMGISCMVVLLSLRLLSQVNFKQDTPVTRRLKKILWY----ISISRNALVVFFTG 298
              ||:  .|...|:..:||.::::.|:. .|:...||...::.|:..    ||...|....:..|
Human   267 --TNL--ADFTAGLLTIVVCMAVKELND-RFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAG 326

  Fly   299 LLVFIWVKKSSIEAVPFALSSKVSSAMPTIKLPPFAFEYQNRTYVFTDILHELGSGIVVVPIVAV 363
            :          ::::|       ...:|. :|||.:        :|:::|    :....:.:||.
Human   327 I----------VKSIP-------RGFLPP-ELPPVS--------LFSEML----AASFSIAVVAY 361

  Fly   364 LANVAIAKAFVK--DGNLDASQEMLTLGLCNIAGSFFSAMPTCGAFTRSAVSQASGVRTPMAGIY 426
            ...|::.|.:..  |..:|.:||.:..|:.||...|||......|.:|:||.:::|.:|.:|||.
Human   362 AIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGII 426

  Fly   427 TGLIVLSALSILTPYFQYIPKASLSAVLIAAV--IFMIDLAPVKELWQTNKKDFFSWVGSFIICL 489
            :..||:.|:..|....:.:.|:.|:||:||.:  :|| .|..:..||:.||.|...||.:.|:.:
Human   427 SAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFM-QLCDIPRLWRQNKIDAVIWVFTCIVSI 490

  Fly   490 VAGVELGLLFGIVLSMVFILLRLGNP--------------KFEVTLKQHESTYYVHIVP-QSDVY 539
            :.|::||||.|::..::.::||:..|              |.....|..|....|.|:. .|.::
Human   491 ILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIF 555

  Fly   540 YTGVDALRSELRG-----ACRLYHN---------------------------------------- 559
            |..||..:..::.     |.|:|:.
Human   556 YGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDED 620

  Fly   560 -------DFP---------------------------VVLDCARFMQFDATFSEMLISVAKE--- 587
                   |.|                           :||||......|......|..:.||
Human   621 IEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQR 685

  Fly   588 ----------------------------------MASHDVLLILQNMSLKVQQ----MLPVMGNV 614
                                              :..||.:|.||| .:|.|:    :|..:..:
Human   686 IDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQN-QVKSQEGQGSILETITLI 749

  Fly   615 RFCQEDSQL------SSHLQVEKEA 633
            :.|::..:|      ...|.|:.||
Human   750 QDCKDTLELIETELTEEELDVQDEA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6125	NP_732032.1	sulP	87..620	CDD:273284	163/719 (23%)
		HCO3_cotransp	108..462	CDD:304903	105/404 (26%)
		STAS	530..608	CDD:294402	27/198 (14%)
SLC26A4	NP_000432.1	sulP	70..725	CDD:273284	154/688 (22%)
		STAS_SulP_like_sulfate_transporter	536..722	CDD:132913	21/185 (11%)
		Snf7	<583..654	CDD:304451	2/70 (3%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910