DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6125 and Prestin

DIOPT Version :9

Sequence 1:	NP_732032.1	Gene:	CG6125 / 41882	FlyBaseID:	FBgn0038337	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	123/546 - (22%)
Similarity:	230/546 - (42%)	Gaps:	121/546 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LSWITSYD-REQAFADLIAGITLGLTIIPQSIAYAALAGLSSEYGLYSAFIGSIIYVFFGTIPQV 150
            |.|:..|. |.....|:|||.|:.:..||..:||..|||:|:..|||.|....:.|:|.||...:
  Fly    84 LQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHI 148

  Fly   151 SIGPTSLMAILTLQF---------------------------------------CADK------- 169
            |||..::.:::|.:.                                       .||.
  Fly   149 SIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTIS 213

  Fly   170 ---------------PVQVVIVLAFLAGLVELAMGVFQLGFIVSFIPAPVTKAFTSGTALIVVFA 219
                           .::|...||...|:|.|.|...:||.:.|.:..|:...||:..|..||.|
  Fly   214 PFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTA 278

  Fly   220 QIKNLLGV---RIKG----FPSIGDFFTNIRPTDAAMGISCMVVLLSLRLLSQVNFKQDTPVTRR 277
            |:|::||:   |.||    ..::.|....:..|:......||.|:..:.:.:::       :..|
  Fly   279 QLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEI-------LKPR 336

  Fly   278 L-KKILWYISISRNALVVFFTGLLVFIWVK---KSSIEAVPFALSSKVSSAMPTIKLPPFAFEYQ 338
            | ||..:.:...   |::...|.|:..|..   ..::..|     .|:.|.:|...||..
  Fly   337 LSKKCRFPLPAE---LIMVIGGTLISKWFNLYVDYNVNPV-----GKIPSGLPEPVLPRL----- 388

  Fly   339 NRTYVFTDILHELGSGIVVVPIVAVLANVAIAKAFVKDGNLDA--SQEMLTLGLCNIAGSFFSAM 401
                   |::.::....:.:.||.....:::...|.|....:.  :||:..:|:.|:.|..||.:
  Fly   389 -------DLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCI 446

  Fly   402 PTCGAFTRSAVSQASGVRTPMAGIYTGLIVLSALSILTPYFQYIPKASLSAVLIAAV--IFMIDL 464
            |...:.:||.:...:|..:.:|.:.:..:|:..|..:.|:|..:|:..|:.|:|.|:  :|| ..
  Fly   447 PMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFM-QA 510

  Fly   465 APVKELWQTNKKDFFSWVGSFIICLVAGVELGLLFGIVLSMVFILLR--------LG----NPKF 517
            ..:|:..:..|.:.|:|:.:|:..::..:::|||.||.:|::.:.::        ||    .|..
  Fly   511 KELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGI 575

  Fly   518 EVTLKQHESTYYVHIVPQSDVY-YTG 542
            .:.|.||.:...   ||:..:: |:|
  Fly   576 YMDLNQHRNAMQ---VPEVRIFRYSG 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6125	NP_732032.1	sulP	87..620	CDD:273284	123/546 (23%)
		HCO3_cotransp	108..462	CDD:304903	92/429 (21%)
		STAS	530..608	CDD:294402	4/14 (29%)
Prestin	NP_649024.1	sulP	82..731	CDD:273284	123/546 (23%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439037
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
	6	5.840