Protein Alignment CG6125 and SLC26A5

DIOPT Version :10

• Sequence 1: NP_732032.1
• Gene: CG6125 / 41882
• FlyBaseID: FBgn0038337
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_945350.1
• Gene: SLC26A5 / 375611
• HGNCID: 9359
• Length: 744
• Species: Homo sapiens
• Alignment Length: 728
• Identity: 164/728 - (22%)
• Similarity: 301/728 - (41%)
• Gaps: 191/728 - (26%)

  Fly    61 HTVDL---DVASKYSK-----PKEAHWLVRRIFFL-----SWITSYD-REQAFADLIAGITLGLT 111
            ||.|.   .:|.|..:     ||:    :|.|.::     .|:.:|. :|....||::||:.|:.
Human    33 HTKDKVPDSIADKLKQAFTCTPKK----IRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVL 93

  Fly   112 IIPQSIAYAALAGLSSEYGLYSAFIGSIIYVFFGTIPQVSIGPTSLMAIL----TLQFCADK--- 169
            .:||.:|:|.||.:...:||||:|...|:|.|.||...:||||.::::::    .::...|.
Human    94 QLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVI 158

  Fly   170 ----------------PVQVVIVLAFLAGLVELAMGVFQLGFIVSFIPAPVTKAFTSGTALIVVF 218
                            .|:|.:.:..|:|:::..:||.:.||:..::..|:.:.||:..|:.|..
Human   159 PGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFT 223

  Fly   219 AQIKNLLGVRIKGFPSIGDFFTNIRPTDA-----------AMGISCMV--VLLSLRLLSQVNFKQ 270
            :.:|.|.||:.|.:..|   |:.:..|.|           ::|:..||  :||..:..:: .||:
Human   224 SMLKYLFGVKTKRYSGI---FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNE-RFKE 284

  Fly   271 DTPVTRRLKKILWYISISRNALVVFFTGLLVFIWVKKS-SIEAVPFALSSKVSSAMPTIKLPPFA 334
            ..|....|:..          .||..||:.....:|:| :::.|         ..:|...|||..
Human   285 KLPAPIPLEFF----------AVVMGTGISAGFNLKESYNVDVV---------GTLPLGLLPPAN 330

  Fly   335 FEYQNRTYVFTDILHELGSGIVVVPIVAVLANVAIAKAFV-KDG-NLDASQEMLTLGLCNIAGSF 397
            .:        |.:.|.:....:.:.||.....:::||... |.| .:|.:||::.|||||..||.
Human   331 PD--------TSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSL 387

  Fly   398 FSAMPTCGAFTRSAVSQASGVRTPMAGIYTGLIVLSALSILTPYFQYIPKASLSAVLIAAV--IF 460
            |.......:.:||.|.:.:|.:|.:||....|::|..:......|:.:|:|.|||::|..:  :|
Human   388 FQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMF 452

  Fly   461 MIDLAPVKELWQTNKKDFFSWVGSFIICLVAGVELGLLFGIVLSMVFILLRLGNPKFEVTLKQHE 525
            | ..:.:...|:|:|.:...|:.:|:..|..|::.||:..::::::.::.|..:|.::|..|..|
Human   453 M-QFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPE 516

  Fly   526 STYYVHI--------VP-------QSDVYYTGVDALRSEL---------------RGACRLYHND 560
            :..|:.|        :|       .:.:||...|...:.|               |.|.|.|..:
Human   517 TDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKE 581

  Fly   561 -------------------------------------------FP---------------VVLDC 567
                                                       ||               |:||.
Human   582 VGNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDF 646

  Fly   568 ARFMQFDATFSEMLISVAKEMASHDVLLILQNMSLKVQQML--------PVMGNVRFCQ-EDSQL 623
            .:....|:...:.|..:.||.....:.:.|...|.:|...|        |.:..:.|.. .|:.|
Human   647 TQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAVL 711

  Fly   624 SSHLQ---VEKEA 633
            .|.|:   .|:||
Human   712 GSQLREALAEQEA 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6125	NP_732032.1	PRK11660	87..620	CDD:481320	148/676 (22%)
SLC26A5	NP_945350.1	PRK11660	66..709	CDD:481320	148/674 (22%)
		Involved in motor function. /evidence=ECO:0000250|UniProtKB:Q9JKQ2	158..168		0/9 (0%)
		Extended region for STAS domain. /evidence=ECO:0000250|UniProtKB:Q9EPH0	505..718		34/212 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..744		3/7 (43%)