DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6125 and slc26a5

DIOPT Version :9

Sequence 1:	NP_732032.1	Gene:	CG6125 / 41882	FlyBaseID:	FBgn0038337	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_958881.1	Gene:	slc26a5 / 322846	ZFINID:	ZDB-GENE-030131-1566	Length:	739	Species:	Danio rerio

Alignment Length:	723	Identity:	166/723 - (22%)
Similarity:	306/723 - (42%)	Gaps:	197/723 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 YGQAHTVDLDVASKYSKPKEAHWL------------VRRIFF-----LSWITSYD-REQAFADLI 103
            :.:|: :|.::..|..|..:.:.|            |:.:.|     |:|:.||. :|..|.|::
Zfish    23 FSEAY-IDSELLHKRKKTPKPYKLRVAEHLCCSSEKVKSVVFGFLPILTWLPSYPLKEYLFGDIV 86

  Fly   104 AGITLGLTIIPQSIAYAALAGLSSEYGLYSAFIGSIIYVFFGTIPQVSIG--------------- 153
            :||:.|:..:||.:|||.||.:...:||||:|...::|.||||...:|||
Zfish    87 SGISTGVMQLPQGLAYAMLAAVPPVFGLYSSFYPVLLYTFFGTSKHISIGTFAVISLMIGGVAVR 151

  Fly   154 --PTSLM--------AILTLQFCADKPVQVVIVLAFLAGLVELAMGVFQLGFIVSFIPAPVTKAF 208
              |.|:.        .::.::....:.|:||:.|..|.|:::..:|:.:.||:..::..|:.:.|
Zfish   152 EAPDSMFMVNGTNSSLVVNIEARDSRRVEVVVALTTLVGIIQFVLGLLRFGFLAIYLTEPLVRGF 216

  Fly   209 TSGTALIVVFAQIKNLLGVRIKGFP-------SIGDFFTNIRPTDAA---MGISCMVVLLSLRLL 263
            |:..|:.|..:|:|.||||:...|.       |:.....||..|:..   :|:.|.|.|..::.|
Zfish   217 TTAAAVHVSVSQLKYLLGVKTARFNGPLSVVYSLDAVLRNIADTNIVTLIIGLGCTVFLYIIKQL 281

  Fly   264 SQVNFKQDTPVTRRLKKILWYISISRNALVVFF-TGLLVFIWVKKS-SIEAVPFALSSKVSSAMP 326
            :: .||         ||:|  |.|....:||.. ||:...:.:.:: .::.|         ..:|
Zfish   282 NE-RFK---------KKLL--IPIPGEIIVVIVSTGISYGMLMSENYGVDVV---------GKIP 325

  Fly   327 TIKLPPFAFEYQNRTYVFTDILHELGSGIVVVPIVAVLANVAIAKAF-VKDG-NLDASQEMLTLG 389
            |..|||...::.....:|.|        .|.:.:|.....:::||.| :|.| ::|.:||::.||
Zfish   326 TGLLPPKVPDFSVFPNLFAD--------AVPIAVVGFSITISLAKTFALKYGYSVDGNQELIALG 382

  Fly   390 LCNIAGSFFSAMPTCGAFTRSAVSQASGVRTPMAGIYTGLIVLSALSILTPYFQYIPKASLSAVL 454
            |||...|||.......:.:||.|.:::|..|.:||:...|:||..:..:...||.:|...|:|::
Zfish   383 LCNFVSSFFHTFVVTASMSRSLVQESTGGHTEIAGLLASLLVLLVVVAIGFVFQPLPTTVLAAII 447

  Fly   455 IAAVIFMI-DLAPVKELWQTNKKDFFSWVGSFIICLVAGVELGLLFGIVLSMVFILLRLGNPK-- 516
            :..::.|. ....:..||:.:|.:...|:.||...::.|::.||...:..:::.::.|...||
Zfish   448 MVNLLGMFKQTRDIPVLWRKSKIELAIWLVSFFASVLLGLDYGLAVAMAFAILTVIYRTQRPKNV 512

  Fly   517 -----------FEV-------------TLKQHESTYYVHIVPQSDVYY------TGV------DA 545
                       |:|             ..:.:.|.|:.:    |::|.      ||:      ||
Zfish   513 VLGQIPDTGLYFDVDEYEEAEECSGIKIFQSNSSIYFAN----SELYVKALKAKTGIDPEKLLDA 573

  Fly   546 LRSELRGACR------------LYHNDFPVVLDCAR----------------------------- 569
            .:.:|:.|.|            |...:..|:||...
Zfish   574 KKLQLKYAKRDTEGTKTVNQGSLLKKNAVVLLDMELGVTHEVLNGPQKPKHVHTNGQMTEKHIES 638

  Fly   570 ------FMQ-----------------FDATFSEMLISVAKEMASHDVLLILQNMSLKVQQMLPVM 611
                  |:|                 .|:..::.:.||.||.|:.||.::|...|   :.:|..:
Zfish   639 ESEDEFFLQRLTPIHSVILDFTPVNFIDSVGAKTIKSVIKEYATVDVKVVLAGCS---RTLLSEL 700

  Fly   612 GNVRFCQE 619
            ..::|..|
Zfish   701 RTLQFFSE 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6125	NP_732032.1	sulP	87..620	CDD:273284	159/676 (24%)
		HCO3_cotransp	108..462	CDD:304903	105/392 (27%)
		STAS	530..608	CDD:294402	25/153 (16%)
slc26a5	NP_958881.1	sulP	67..722	CDD:273284	159/678 (23%)
		LrgB	259..>366	CDD:294396	30/135 (22%)
		STAS_SulP_like_sulfate_transporter	<643..719	CDD:132913	15/69 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810