DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6125 and Slc26a4

DIOPT Version :9

Sequence 1:	NP_732032.1	Gene:	CG6125 / 41882	FlyBaseID:	FBgn0038337	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_035997.1	Gene:	Slc26a4 / 23985	MGIID:	1346029	Length:	780	Species:	Mus musculus

Alignment Length:	755	Identity:	167/755 - (22%)
Similarity:	300/755 - (39%)	Gaps:	235/755 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KEAHWLVRRIF-FLSWITSYD-REQAFADLIAGITLGLTIIPQSIAYAALAGLSSEYGLYSAFIG 137
            |.|..:|:.:. .|.|:..|. :|...:|:|:|::.||....|.:|||.||.:..::||||||..
Mouse    59 KRAFGVVKTLLPILDWLPKYRVKEWLLSDIISGVSTGLVGTLQGMAYALLAAVPVQFGLYSAFFP 123

  Fly   138 SIIYVFFGTIPQVSIGPTSLMAIL---------------------------TLQFCADKPVQVVI 175
            .:.|..|||...:|:||..:::::                           ||........:|::
Mouse   124 ILTYFVFGTSRHISVGPFPVVSLMVGSVVLSMAPDDHFLVPSGNGSALNSTTLDTGTRDAARVLL 188

  Fly   176 --VLAFLAGLVELAMGVFQLGFIVSFIPAPVTKAFTSGTALIVVFAQIKNLLGVRIKG------- 231
              .|..|.|:::|..|..|:||||.::..|:...||:..|..|:.:|:|.:|.|..|.
Mouse   189 ASTLTLLVGIIQLVFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGILSI 253

  Fly   232 -------FPSIGDFFTNIRPTDAAMGISCMVVLLSLRLLSQVNFKQDTPVTRRLKKILWY----I 285
                   |.:|||  |||  .|...|:..::|.::::.|:. .||...||...::.|:..    |
Mouse   254 IYTLIEIFQNIGD--TNI--ADFIAGLLTIIVCMAVKELND-RFKHRIPVPIPIEVIVTIIATAI 313

  Fly   286 SISRNALVVFFTGLLVFIWVKKSSIEAVPFALSSKVSSAMPTIKLPPFAFEYQNRTYVFTDILHE 350
            |...|....:..|:          ::::|   |..:...:|::.|             |:|:|
Mouse   314 SYGANLEKNYNAGI----------VKSIP---SGFLPPVLPSVGL-------------FSDML-- 350

  Fly   351 LGSGIVVVPIVAVLANVAIAKAFV--KDGNLDASQEMLTLGLCNIAGSFFSAMPTCGAFTRSAVS 413
              :....:.:||....|::.|.:.  .|..:|.:||.:..|:.|:...|||......|.:|:||.
Mouse   351 --AASFSIAVVAYAIAVSVGKVYATKHDYVIDGNQEFIAFGISNVFSGFFSCFVATTALSRTAVQ 413

  Fly   414 QASGVRTPMAGIYTGLIVLSALSILTPYFQYIPKASLSAVLIAAV--IFMIDLAPVKELWQTNKK 476
            :::|.:|.:||:.:.:||:.|:..|....:.:.|:.|:||:||.:  :|| .:..|..||:.||.
Mouse   414 ESTGGKTQVAGLISAVIVMVAIVALGRLLEPLQKSVLAAVVIANLKGMFM-QVCDVPRLWKQNKT 477

  Fly   477 DFFSWVGSFIICLVAGVELGLLFGIVLSMVFILLRLGNPKF-------------EVT----LKQH 524
            |...||.:.|:.::.|::||||.|::.:::.::||:..|.:             .:|    |::.
Mouse   478 DAVIWVFTCIMSIILGLDLGLLAGLLFALLTVVLRVQFPSWNGLGSVPSTDIYKSITHYKNLEEP 542

  Fly   525 ESTYYVHIVPQSDVYYTGVDALRSELRG-----ACRLY--------------------------- 557
            |....:..  .|.::|..||..:..:..     |.|:|
Mouse   543 EGVKILRF--SSPIFYGNVDGFKKCINSTVGFDAIRVYNKRLKALRRIQKLIKKGQLRATKNGII 605

  Fly   558 -----------------------------------HNDFPV------------VLDCARFMQFDA 575
                                               :::.||            ||||......|.
Mouse   606 SDIGSSNNAFEPDEDVEEPEELNIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAVSFLDV 670

  Fly   576 TFSEMLISVAKE-------------------------------------MASHDVLLILQNMSLK 603
            .....|..:.||                                     :..||.:|.||| .:|
Mouse   671 VGVRSLRMIVKEFQRIDVNVYFALLQDDVLEKMEQCGFFDDNIRKDRFFLTVHDAILHLQN-QVK 734

  Fly   604 VQQ----MLPVMGNVRFCQEDSQL------SSHLQVEKEA 633
            .::    :|..:..:|.|::...|      :..|.|:.||
Mouse   735 SREGQDSLLETVARIRDCKDPLDLMEAEMNAEELDVQDEA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6125	NP_732032.1	sulP	87..620	CDD:273284	159/721 (22%)
		HCO3_cotransp	108..462	CDD:304903	103/404 (25%)
		STAS	530..608	CDD:294402	24/197 (12%)
Slc26a4	NP_035997.1	sulP	70..725	CDD:273284	150/692 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810