DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6125 and Slc26a1

DIOPT Version :9

Sequence 1:	NP_732032.1	Gene:	CG6125 / 41882	FlyBaseID:	FBgn0038337	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001297620.1	Gene:	Slc26a1 / 231583	MGIID:	2385894	Length:	720	Species:	Mus musculus

Alignment Length:	677	Identity:	149/677 - (22%)
Similarity:	280/677 - (41%)	Gaps:	148/677 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 AHWLVRRIF-FLSWITSYD-REQAFADLIAGITLGLTIIPQSIAYAALAGLSSEYGLYSAFIGSI 139
            |..||:.:| .:.|:..|. :|....|:::|:.:|:.::||:|||:.||||...|.||::|..::
Mouse    62 AQALVQGLFPAIHWLPQYRLKEYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANL 126

  Fly   140 IYVFFGTIPQVSIGPTSLMAILT-------LQFCADKP--------------------------- 170
            ||...||...|::|..||:.::.       ||.....|
Mouse   127 IYFLMGTSRHVNVGIFSLLCLMVGQVVDRELQLAGFDPSQDSLGPKNNDSTLNNSATTLIIGLQD 191

  Fly   171 -------VQVVIVLAFLAGLVELAMGVFQLGFIVSFIPAPVTKAFTSGTALIVVFAQIKNLLGVR 228
                   ::|...|..:|||.::.||:.:|||:.:::..|:...|..|.::.::.:|.|::|||:
Mouse   192 CRRDCYAIRVATALTLMAGLYQVLMGILRLGFVSTYLSQPLLDGFAMGASVTILTSQAKHMLGVQ 256

  Fly   229 IKGFPSIG-------DFFTNIRPT---DAAMGISCMVVLLSLRLLSQVNFKQDTPVTRRLKKILW 283
            |.....:|       ....|:...   |......|:.|||:.:.||.       ....|||
Mouse   257 IPRHQGLGMVVHTWLSLLQNVGQANICDVVTSALCLGVLLAAKELSD-------RYRHRLK---- 310

  Fly   284 YISISRNALVVFFTGLLVFIWVKKSSIEAVPFALSSKVSSAMPTIKLPPFAFEYQNRTYVFTDIL 348
             :.|.....|:....::       |....:.....|:|:..:||..:.|...:        ..|:
Mouse   311 -VPIPTELFVIVVATIV-------SHFGQLHTRFDSRVAGNIPTGFVAPQVPD--------PKIM 359

  Fly   349 HELGSGIVVVPIVAVLANVAIAKAFVKDG--NLDASQEMLTLGLCNIAGSFFSAMPTCGAFTRSA 411
            ..:....:.:.:|....::::|:.|.:..  ::.|:||:|.:|.||:..:||....|..|.:::.
Mouse   360 WRVALDAMSLALVGSAFSISLAEMFARSHGYSVSANQELLAVGCCNVLPAFFHCFATSAALSKTL 424

  Fly   412 VSQASGVRTPMAGIYTGLIVLSALSILTPYFQYIPKASLSAVLIAAVIFMI-DLAPVKELWQTNK 475
            |..|:|.:|.::.:.:..:||..|.:|.|.|..:.:..|:.:::.::...: .:..:.:||:.:.
Mouse   425 VKIATGCQTQLSSVVSAAVVLLVLLVLAPLFHDLQRCVLACIIVVSLRGALRKVKDLPQLWRLSP 489

  Fly   476 KDFFSWVGSFIICLVAGVELGLLFGIVLSMVFILLRLGNPKFEVTLKQHESTYYVH------IVP 534
            .|...||.:...|::...|.|||.|:..|::.:..|...|:..:..:..:||:|..      ::|
Mouse   490 ADALVWVATAATCVLVSTEAGLLAGVFFSLLSLAGRTQRPRAALLARIGDSTFYEDAAEFEGLLP 554

  Fly   535 QSDV---------YY-------------TGVDALRSELR-------------------------G 552
            ..:|         ||             ||:||..|..|                         |
Mouse   555 PPEVRVFRFTGPLYYANKDFFLRSLYRLTGLDAGHSATRKDQGPEVGVSNRSLVDGKDLGSVSSG 619

  Fly   553 ACRL------YHNDFPVVLDCARFMQFDATFSEMLISVAKEMASHDVLLILQNMSLKVQQMLPVM 611
            |..:      :|.   ||:|||..:..|......|..:.::..:.|:.|:|...|..|:..|...
Mouse   620 AGLVVPLAFGFHT---VVIDCAPLLFLDVAGMATLKDLRRDYRALDITLLLACCSPSVRDTLRKG 681

  Fly   612 GNVRFCQEDSQLSSHLQVEKEAPVVEA 638
            |   |..|:....:.|........|||
Mouse   682 G---FLGEEQGAENELLFPSVHSAVEA 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6125	NP_732032.1	sulP	87..620	CDD:273284	140/646 (22%)
		HCO3_cotransp	108..462	CDD:304903	90/406 (22%)
		STAS	530..608	CDD:294402	25/136 (18%)
Slc26a1	NP_001297620.1	sulP	71..702	CDD:273284	142/663 (21%)
Slc26a1	NP_001297620.1	STAS_SulP_like_sulfate_transporter	554..686	CDD:132913	28/137 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810